| MAREČKOVÁ, Klára, A. KLASNJA, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL and T. PAUS. Developmental origins of depression-related white matter properties: Findings from a prenatal birth cohort. Human Brain mapping. USA: WILEY, 2019, vol. 40, No 4, p. 1155-1163. ISSN 1065-9471. Available from: https://dx.doi.org/10.1002/hbm.24435. |
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@article{1508837,
author = {Marečková, Klára and Klasnja, A. and Andrýsková, Lenka and Brázdil, Milan and Paus, T.},
article_location = {USA},
article_number = {4},
doi = {http://dx.doi.org/10.1002/hbm.24435},
keywords = {adolescence; cohort studies; depression; diffusion tensor imaging; life stress; prenatal development; white matter},
language = {eng},
issn = {1065-9471},
journal = {Human Brain mapping},
title = {Developmental origins of depression-related white matter properties: Findings from a prenatal birth cohort},
url = {https://onlinelibrary.wiley.com/doi/full/10.1002/hbm.24435},
volume = {40},
year = {2019}
}
TY - JOUR
ID - 1508837
AU - Marečková, Klára - Klasnja, A. - Andrýsková, Lenka - Brázdil, Milan - Paus, T.
PY - 2019
TI - Developmental origins of depression-related white matter properties: Findings from a prenatal birth cohort
JF - Human Brain mapping
VL - 40
IS - 4
SP - 1155-1163
EP - 1155-1163
PB - WILEY
SN - 10659471
KW - adolescence
KW - cohort studies
KW - depression
KW - diffusion tensor imaging
KW - life stress
KW - prenatal development
KW - white matter
UR - https://onlinelibrary.wiley.com/doi/full/10.1002/hbm.24435
L2 - https://onlinelibrary.wiley.com/doi/full/10.1002/hbm.24435
N2 - Depression is the leading cause of years lost due to disability worldwide. Still, the mechanisms underlying its development are not well understood. This study aimed to evaluate white-matter properties associated with depressive symptomatology in young adulthood and their developmental origins. Diffusion tensor imaging and assessment of depressive symptomatology were conducted in 128 young adults (47% male, age 23-24) from a prenatal birth cohort (European Longitudinal Study of Pregnancy and Childhood). For a subset of these individuals, the database included information on prenatal stress (n = 93) and depressive symptoms during adolescence (assessed repeatedly at age 15 and 19). Depressive symptoms in young adulthood were associated with lower fractional anisotropy in the left and right cingulum and higher fractional anisotropy in the right corticospinal tract and superior longitudinal fasciculus. Further analyses revealed that prenatal stress and depressive symptomatology during adolescence were independent predictors of altered white-matter properties in the cingulum in young adulthood. We conclude that typically developing young adults with more depressive symptoms already exhibit tract-specific alterations in white-matter properties and that prenatal stress and depressive symptomatology during adolescence might contribute to their development.
ER -
MAREČKOVÁ, Klára, A. KLASNJA, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL and T. PAUS. Developmental origins of depression-related white matter properties: Findings from a prenatal birth cohort. \textit{Human Brain mapping}. USA: WILEY, 2019, vol.~40, No~4, p.~1155-1163. ISSN~1065-9471. Available from: https://dx.doi.org/10.1002/hbm.24435.
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