Detailed Information on Publication Record
2019
Developmental origins of depression-related white matter properties: Findings from a prenatal birth cohort
MAREČKOVÁ, Klára, A. KLASNJA, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL, T. PAUS et. al.Basic information
Original name
Developmental origins of depression-related white matter properties: Findings from a prenatal birth cohort
Authors
MAREČKOVÁ, Klára (203 Czech Republic, guarantor, belonging to the institution), A. KLASNJA (124 Canada), Lenka ANDRÝSKOVÁ (203 Czech Republic, belonging to the institution), Milan BRÁZDIL (203 Czech Republic, belonging to the institution) and T. PAUS (124 Canada)
Edition
Human Brain mapping, USA, WILEY, 2019, 1065-9471
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30103 Neurosciences
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 4.421
RIV identification code
RIV/00216224:14740/19:00109323
Organization unit
Central European Institute of Technology
UT WoS
000459470400008
Keywords in English
adolescence; cohort studies; depression; diffusion tensor imaging; life stress; prenatal development; white matter
Tags
International impact, Reviewed
Změněno: 8/10/2024 08:24, Ing. Jana Kuchtová
Abstract
V originále
Depression is the leading cause of years lost due to disability worldwide. Still, the mechanisms underlying its development are not well understood. This study aimed to evaluate white-matter properties associated with depressive symptomatology in young adulthood and their developmental origins. Diffusion tensor imaging and assessment of depressive symptomatology were conducted in 128 young adults (47% male, age 23-24) from a prenatal birth cohort (European Longitudinal Study of Pregnancy and Childhood). For a subset of these individuals, the database included information on prenatal stress (n = 93) and depressive symptoms during adolescence (assessed repeatedly at age 15 and 19). Depressive symptoms in young adulthood were associated with lower fractional anisotropy in the left and right cingulum and higher fractional anisotropy in the right corticospinal tract and superior longitudinal fasciculus. Further analyses revealed that prenatal stress and depressive symptomatology during adolescence were independent predictors of altered white-matter properties in the cingulum in young adulthood. We conclude that typically developing young adults with more depressive symptoms already exhibit tract-specific alterations in white-matter properties and that prenatal stress and depressive symptomatology during adolescence might contribute to their development.
Links
EF16_013/0001761, research and development project |
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LM2015051, research and development project |
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LQ1601, research and development project |
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MUNI/E/0566/2018, interní kód MU |
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90062, large research infrastructures |
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