J 2019

Developmental origins of depression-related white matter properties: Findings from a prenatal birth cohort

MAREČKOVÁ, Klára, A. KLASNJA, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL, T. PAUS et. al.

Basic information

Original name

Developmental origins of depression-related white matter properties: Findings from a prenatal birth cohort

Authors

MAREČKOVÁ, Klára (203 Czech Republic, guarantor, belonging to the institution), A. KLASNJA (124 Canada), Lenka ANDRÝSKOVÁ (203 Czech Republic, belonging to the institution), Milan BRÁZDIL (203 Czech Republic, belonging to the institution) and T. PAUS (124 Canada)

Edition

Human Brain mapping, USA, WILEY, 2019, 1065-9471

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 4.421

RIV identification code

RIV/00216224:14740/19:00109323

Organization unit

Central European Institute of Technology

UT WoS

000459470400008

Keywords in English

adolescence; cohort studies; depression; diffusion tensor imaging; life stress; prenatal development; white matter

Tags

Tags

International impact, Reviewed
Změněno: 8/10/2024 08:24, Ing. Jana Kuchtová

Abstract

V originále

Depression is the leading cause of years lost due to disability worldwide. Still, the mechanisms underlying its development are not well understood. This study aimed to evaluate white-matter properties associated with depressive symptomatology in young adulthood and their developmental origins. Diffusion tensor imaging and assessment of depressive symptomatology were conducted in 128 young adults (47% male, age 23-24) from a prenatal birth cohort (European Longitudinal Study of Pregnancy and Childhood). For a subset of these individuals, the database included information on prenatal stress (n = 93) and depressive symptoms during adolescence (assessed repeatedly at age 15 and 19). Depressive symptoms in young adulthood were associated with lower fractional anisotropy in the left and right cingulum and higher fractional anisotropy in the right corticospinal tract and superior longitudinal fasciculus. Further analyses revealed that prenatal stress and depressive symptomatology during adolescence were independent predictors of altered white-matter properties in the cingulum in young adulthood. We conclude that typically developing young adults with more depressive symptoms already exhibit tract-specific alterations in white-matter properties and that prenatal stress and depressive symptomatology during adolescence might contribute to their development.

Links

EF16_013/0001761, research and development project
Name: RECETOX RI
LM2015051, research and development project
Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)
Investor: Ministry of Education, Youth and Sports of the CR
LQ1601, research and development project
Name: CEITEC 2020 (Acronym: CEITEC2020)
Investor: Ministry of Education, Youth and Sports of the CR
MUNI/E/0566/2018, interní kód MU
Name: Developmental origins of depression-related white matter properties (Acronym: DeOrDe)
Investor: Masaryk University, Promoting quality excellence
90062, large research infrastructures
Name: Czech-BioImaging