New diterpenoid glucoside and flavonoids from Plectranthus
scutellarioides (L.) R. Br.

J 2019

New diterpenoid glucoside and flavonoids from Plectranthus scutellarioides (L.) R. Br.

KUBÍNOVÁ, Renata, Markéta GAZDOVÁ, Zuzana HANÁKOVÁ, Sabína JUSKOVÁ, Acqua S DALL et. al.

Basic information

Original name

New diterpenoid glucoside and flavonoids from Plectranthus scutellarioides (L.) R. Br.

Authors

KUBÍNOVÁ, Renata (203 Czech Republic), Markéta GAZDOVÁ (203 Czech Republic), Zuzana HANÁKOVÁ (203 Czech Republic), Sabína JUSKOVÁ (203 Czech Republic), Acqua S DALL (380 Italy), Josef CVAČKA (203 Czech Republic) and Otakar HUMPA (203 Czech Republic, guarantor, belonging to the institution)

Edition

SOUTH AFRICAN JOURNAL OF BOTANY, AMSTERDAM, ELSEVIER SCIENCE BV, 2019, 0254-6299

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10401 Organic chemistry

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.792

RIV identification code

RIV/00216224:14740/19:00109325

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1016/j.sajb.2018.08.023

UT WoS

000456314600038

Keywords in English

Plectranthus scutellarioides; Diterpene glucoside; Flavonoids; Hyaluronidase; ORAC values; Acetylcholinesterase and butyrylcholinesterase; inhibitory activities

Abstract

V originále

Three new compounds, diterpenoid glucoside (13S, 15S)-6 beta, 7 alpha, 12 alpha-trihydroxy-13 beta, 16-cyclo-8-abietene11,14- dione 7-O-beta-D-glucoside 1, flavonoids apigenin 7-O-(3''-O-acetyl)-beta-D-glucuronide 2 and apigenin 5-O( 3''-O-acetyl)-beta-D-glucuronide 3, together with known compounds caffeic acid 4, luteolin 5-O-beta-D-glucoside 5 and rosmarinic acid 6 were isolated from the aerial parts of Plectranthus scutellarioides (L.) R. Br. The structures of the new compounds were elucidated by spectroscopic and mass-spectrometric analyses, including 1D-and 2D-NMR. Compound 1 inhibited hyaluronidase by 25% at the concentration of 200 mu M, compounds 2 and 3 showed inhibitory activity on butyrylcholinesterase better than standard galanthamine at the concentration of 100 mu M, and compound 6 is a potent antioxidant with an ORAC value of 2.15 +/- 0.12. (c) 2018 SAAB. Published by Elsevier B. V. All rights reserved.

Links

LM2011020, research and development project

Name: CEITEC ? open access

Investor: Ministry of Education, Youth and Sports of the CR

90043, large research infrastructures

Name: CIISB

Citovat

KUBÍNOVÁ, Renata, Markéta GAZDOVÁ, Zuzana HANÁKOVÁ, Sabína JUSKOVÁ, Acqua S DALL, Josef CVAČKA and Otakar HUMPA. New diterpenoid glucoside and flavonoids from Plectranthus scutellarioides (L.) R. Br. SOUTH AFRICAN JOURNAL OF BOTANY. AMSTERDAM: ELSEVIER SCIENCE BV, 2019, vol. 120, 0254-6299, p. 286-290. ISSN 0254-6299. Available from: https://dx.doi.org/10.1016/j.sajb.2018.08.023.

@article{1509096,
   author = {Kubínová, Renata and Gazdová, Markéta and Hanáková, Zuzana and Jusková, Sabína and Dall, Acqua S and Cvačka, Josef and Humpa, Otakar},
   article_location = {AMSTERDAM},
   article_number = {0254-6299},
   doi = {http://dx.doi.org/10.1016/j.sajb.2018.08.023},
   keywords = {Plectranthus scutellarioides; Diterpene glucoside; Flavonoids; Hyaluronidase; ORAC values; Acetylcholinesterase and butyrylcholinesterase; inhibitory activities},
   language = {eng},
   issn = {0254-6299},
   journal = {SOUTH AFRICAN JOURNAL OF BOTANY},
   title = {New diterpenoid glucoside and flavonoids from Plectranthus scutellarioides (L.) R. Br.},
   url = {https://www.sciencedirect.com/science/article/pii/S0254629918308366},
   volume = {120},
   year = {2019}
}

TY  - JOUR
ID  - 1509096
AU  - Kubínová, Renata - Gazdová, Markéta - Hanáková, Zuzana - Jusková, Sabína - Dall, Acqua S - Cvačka, Josef - Humpa, Otakar
PY  - 2019
TI  - New diterpenoid glucoside and flavonoids from Plectranthus scutellarioides (L.) R. Br.
JF  - SOUTH AFRICAN JOURNAL OF BOTANY
VL  - 120
IS  - 0254-6299
SP  - 286-290
EP  - 286-290
PB  - ELSEVIER SCIENCE BV
SN  - 02546299
KW  - Plectranthus scutellarioides
KW  - Diterpene glucoside
KW  - Flavonoids
KW  - Hyaluronidase
KW  - ORAC values
KW  - Acetylcholinesterase and butyrylcholinesterase
KW  - inhibitory activities
UR  - https://www.sciencedirect.com/science/article/pii/S0254629918308366
L2  - https://www.sciencedirect.com/science/article/pii/S0254629918308366
N2  - Three new compounds, diterpenoid glucoside (13S, 15S)-6 beta, 7 alpha, 12 alpha-trihydroxy-13 beta, 16-cyclo-8-abietene11,14- dione 7-O-beta-D-glucoside 1, flavonoids apigenin 7-O-(3''-O-acetyl)-beta-D-glucuronide 2 and apigenin 5-O( 3''-O-acetyl)-beta-D-glucuronide 3, together with known compounds caffeic acid 4, luteolin 5-O-beta-D-glucoside 5 and rosmarinic acid 6 were isolated from the aerial parts of Plectranthus scutellarioides (L.) R. Br. The structures of the new compounds were elucidated by spectroscopic and mass-spectrometric analyses, including 1D-and 2D-NMR. Compound 1 inhibited hyaluronidase by 25% at the concentration of 200 mu M, compounds 2 and 3 showed inhibitory activity on butyrylcholinesterase better than standard galanthamine at the concentration of 100 mu M, and compound 6 is a potent antioxidant with an ORAC value of 2.15 +/- 0.12. (c) 2018 SAAB. Published by Elsevier B. V. All rights reserved.
ER  -

KUBÍNOVÁ, Renata, Markéta GAZDOVÁ, Zuzana HANÁKOVÁ, Sabína JUSKOVÁ, Acqua S DALL, Josef CVAČKA and Otakar HUMPA. New diterpenoid glucoside and flavonoids from Plectranthus scutellarioides (L.) R. Br. \textit{SOUTH AFRICAN JOURNAL OF BOTANY}. AMSTERDAM: ELSEVIER SCIENCE BV, 2019, vol.~120, 0254-6299, p.~286-290. ISSN~0254-6299. Available from: https://dx.doi.org/10.1016/j.sajb.2018.08.023.

Detailed Information on Publication Record