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@article{1509199, author = {Paleček, Jan}, article_location = {BASEL}, article_number = {1}, doi = {http://dx.doi.org/10.3390/genes10010007}, keywords = {SMC complexes; SMC5/6; chromatin structure; loop extrusion; stalled replication fork; replication fork regression; collapsed replication fork; homologous recombination}, language = {eng}, issn = {2073-4425}, journal = {GENES}, title = {SMC5/6: Multifunctional Player in Replication}, url = {https://www.mdpi.com/2073-4425/10/1/7}, volume = {10}, year = {2019} }
TY - JOUR ID - 1509199 AU - Paleček, Jan PY - 2019 TI - SMC5/6: Multifunctional Player in Replication JF - GENES VL - 10 IS - 1 SP - 1-14 EP - 1-14 PB - MDPI AG SN - 20734425 KW - SMC complexes KW - SMC5/6 KW - chromatin structure KW - loop extrusion KW - stalled replication fork KW - replication fork regression KW - collapsed replication fork KW - homologous recombination UR - https://www.mdpi.com/2073-4425/10/1/7 L2 - https://www.mdpi.com/2073-4425/10/1/7 N2 - The genome replication process is challenged at many levels. Replication must proceed through different problematic sites and obstacles, some of which can pause or even reverse the replication fork (RF). In addition, replication of DNA within chromosomes must deal with their topological constraints and spatial organization. One of the most important factors organizing DNA into higher-order structures are Structural Maintenance of Chromosome (SMC) complexes. In prokaryotes, SMC complexes ensure proper chromosomal partitioning during replication. In eukaryotes, cohesin and SMC5/6 complexes assist in replication. Interestingly, the SMC5/6 complexes seem to be involved in replication in many ways. They stabilize stalled RFs, restrain RF regression, participate in the restart of collapsed RFs, and buffer topological constraints during RF progression. In this (mini) review, I present an overview of these replication-related functions of SMC5/6. ER -
PALEČEK, Jan. SMC5/6: Multifunctional Player in Replication. \textit{GENES}. BASEL: MDPI AG, 2019, vol.~10, No~1, p.~1-14. ISSN~2073-4425. Available from: https://dx.doi.org/10.3390/genes10010007.
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