PALEČEK, Jan. SMC5/6: Multifunctional Player in Replication. GENES. BASEL: MDPI AG, vol. 10, No 1, p. 1-14. ISSN 2073-4425. doi:10.3390/genes10010007. 2019.
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Basic information
Original name SMC5/6: Multifunctional Player in Replication
Name in Czech SMC5/6: Multifunkční hráč v replikaci
Authors PALEČEK, Jan (203 Czech Republic, guarantor, belonging to the institution).
Edition GENES, BASEL, MDPI AG, 2019, 2073-4425.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10608 Biochemistry and molecular biology
Country of publisher Switzerland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 3.759
RIV identification code RIV/00216224:14310/19:00107323
Organization unit Faculty of Science
Doi http://dx.doi.org/10.3390/genes10010007
UT WoS 000459743800007
Keywords in English SMC complexes; SMC5/6; chromatin structure; loop extrusion; stalled replication fork; replication fork regression; collapsed replication fork; homologous recombination
Tags International impact, Reviewed
Changed by Changed by: Mgr. Pavla Foltynová, Ph.D., učo 106624. Changed: 8/3/2020 19:05.
Abstract
The genome replication process is challenged at many levels. Replication must proceed through different problematic sites and obstacles, some of which can pause or even reverse the replication fork (RF). In addition, replication of DNA within chromosomes must deal with their topological constraints and spatial organization. One of the most important factors organizing DNA into higher-order structures are Structural Maintenance of Chromosome (SMC) complexes. In prokaryotes, SMC complexes ensure proper chromosomal partitioning during replication. In eukaryotes, cohesin and SMC5/6 complexes assist in replication. Interestingly, the SMC5/6 complexes seem to be involved in replication in many ways. They stabilize stalled RFs, restrain RF regression, participate in the restart of collapsed RFs, and buffer topological constraints during RF progression. In this (mini) review, I present an overview of these replication-related functions of SMC5/6.
Links
GA18-02067S, research and development projectName: Úloha Nse1/Nse3/Nse4, E3-ubikvitin ligásy, ve stabilitě genomu
Investor: Czech Science Foundation
LQ1601, research and development projectName: CEITEC 2020 (Acronym: CEITEC2020)
Investor: Ministry of Education, Youth and Sports of the CR
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