| GEISSNER, Andreas, Anika REINHARDT, Christoph RADEMACHER, Timo JOHANNSSEN, João MONTEIRO, Bernd LEPENIES, Michel THEPAUT, Franck FIESCHI, Jana MRÁZKOVÁ, Michaela WIMMEROVÁ, Frank SCHUHMACHER, Sebastian GOTZE, Dan GRUNSTEIN, Xiaoqiang GUO, Heung Sik HAHM, Jeyakumar KANDASAMY, Daniele LEONORI, Christopher E. MARTIN, Sharavathi G. PARAMESWARAPPA, Sandip PASARI, Mark K. SCHLEGEL, Hidenori TANAKA, Guozhi XIAO, You YANG, Claney L. PEREIRA, Chakkumkal ANISH and Peter H. SEEBERGER. Microbe-focused glycan array screening platform. Proceedings of the National Academy of Sciences of the United States of America. WASHINGTON: NATL ACAD SCIENCES, 2019, vol. 116, No 6, p. 1958-1967. ISSN 0027-8424. Available from: https://dx.doi.org/10.1073/pnas.1800853116. |
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@article{1512538,
author = {Geissner, Andreas and Reinhardt, Anika and Rademacher, Christoph and Johannssen, Timo and Monteiro, João and Lepenies, Bernd and Thepaut, Michel and Fieschi, Franck and Mrázková, Jana and Wimmerová, Michaela and Schuhmacher, Frank and Gotze, Sebastian and Grunstein, Dan and Guo, Xiaoqiang and Hahm, Heung Sik and Kandasamy, Jeyakumar and Leonori, Daniele and Martin, Christopher E. and Parameswarappa, Sharavathi G. and Pasari, Sandip and Schlegel, Mark K. and Tanaka, Hidenori and Xiao, Guozhi and Yang, You and Pereira, Claney L. and Anish, Chakkumkal and Seeberger, Peter H.},
article_location = {WASHINGTON},
article_number = {6},
doi = {http://dx.doi.org/10.1073/pnas.1800853116},
keywords = {glycan arrays; microbial antigens; immune receptors; antiglycan antibodies; bacterial lectins},
language = {eng},
issn = {0027-8424},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
title = {Microbe-focused glycan array screening platform},
url = {https://www.pnas.org/content/pnas/116/6/1958.full.pdf},
volume = {116},
year = {2019}
}
TY - JOUR
ID - 1512538
AU - Geissner, Andreas - Reinhardt, Anika - Rademacher, Christoph - Johannssen, Timo - Monteiro, João - Lepenies, Bernd - Thepaut, Michel - Fieschi, Franck - Mrázková, Jana - Wimmerová, Michaela - Schuhmacher, Frank - Gotze, Sebastian - Grunstein, Dan - Guo, Xiaoqiang - Hahm, Heung Sik - Kandasamy, Jeyakumar - Leonori, Daniele - Martin, Christopher E. - Parameswarappa, Sharavathi G. - Pasari, Sandip - Schlegel, Mark K. - Tanaka, Hidenori - Xiao, Guozhi - Yang, You - Pereira, Claney L. - Anish, Chakkumkal - Seeberger, Peter H.
PY - 2019
TI - Microbe-focused glycan array screening platform
JF - Proceedings of the National Academy of Sciences of the United States of America
VL - 116
IS - 6
SP - 1958-1967
EP - 1958-1967
PB - NATL ACAD SCIENCES
SN - 00278424
KW - glycan arrays
KW - microbial antigens
KW - immune receptors
KW - antiglycan antibodies
KW - bacterial lectins
UR - https://www.pnas.org/content/pnas/116/6/1958.full.pdf
L2 - https://www.pnas.org/content/pnas/116/6/1958.full.pdf
N2 - Interactions between glycans and glycan binding proteins are essential for numerous processes in all kingdoms of life. Glycan microarrays are an excellent tool to examine protein-glycan interactions. Here, we present a microbe-focused glycan microarray platform based on oligosaccharides obtained by chemical synthesis. Glycans were generated by combining different carbohydrate synthesis approaches including automated glycan assembly, solution-phase synthesis, and chemoenzymatic methods. The current library of more than 300 glycans is as diverse as the mammalian glycan array from the Consortium for Functional Glycomics and, due to its microbial focus, highly complementary. This glycan platform is essential for the characterization of various classes of glycan binding proteins. Applications of this glycan array platform are highlighted by the characterization of innate immune receptors and bacterial virulence factors as well as the analysis of human humoral immunity to pathogenic glycans.
ER -
GEISSNER, Andreas, Anika REINHARDT, Christoph RADEMACHER, Timo JOHANNSSEN, João MONTEIRO, Bernd LEPENIES, Michel THEPAUT, Franck FIESCHI, Jana MRÁZKOVÁ, Michaela WIMMEROVÁ, Frank SCHUHMACHER, Sebastian GOTZE, Dan GRUNSTEIN, Xiaoqiang GUO, Heung Sik HAHM, Jeyakumar KANDASAMY, Daniele LEONORI, Christopher E. MARTIN, Sharavathi G. PARAMESWARAPPA, Sandip PASARI, Mark K. SCHLEGEL, Hidenori TANAKA, Guozhi XIAO, You YANG, Claney L. PEREIRA, Chakkumkal ANISH and Peter H. SEEBERGER. Microbe-focused glycan array screening platform. \textit{Proceedings of the National Academy of Sciences of the United States of America}. WASHINGTON: NATL ACAD SCIENCES, 2019, vol.~116, No~6, p.~1958-1967. ISSN~0027-8424. Available from: https://dx.doi.org/10.1073/pnas.1800853116.
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