Chemokine Receptor 2 (CXCR2) Gene Variants and Their
Association with Periodontal Bacteria in Patients with Chronic
Periodontitis

J 2019

Chemokine Receptor 2 (CXCR2) Gene Variants and Their Association with Periodontal Bacteria in Patients with Chronic Periodontitis

KAVŘÍKOVÁ, Denisa, Petra BOŘILOVÁ LINHARTOVÁ, Světlana LUČANOVÁ, Hana POSKEROVÁ, Antonín FASSMANN et. al.

Basic information

Original name

Chemokine Receptor 2 (CXCR2) Gene Variants and Their Association with Periodontal Bacteria in Patients with Chronic Periodontitis

Authors

KAVŘÍKOVÁ, Denisa (203 Czech Republic, belonging to the institution), Petra BOŘILOVÁ LINHARTOVÁ (203 Czech Republic, belonging to the institution), Světlana LUČANOVÁ (203 Czech Republic, belonging to the institution), Hana POSKEROVÁ (203 Czech Republic, belonging to the institution), Antonín FASSMANN (203 Czech Republic, belonging to the institution) and Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, belonging to the institution)

Edition

MEDIATORS OF INFLAMMATION, London, HINDAWI LTD, 2019, 0962-9351

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30208 Dentistry, oral surgery and medicine

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.758

RIV identification code

RIV/00216224:14110/19:00107344

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1155/2019/2061868

UT WoS

000459076200001

Keywords in English

Periodontitis

Abstract

V originále

Periodontitis, an inflammatory disease caused by subgingival Gram-negative (G-) bacteria, is linked with loss of the connective tissue and destruction of the alveolar bone. In the regulation of inflammatory response, chemokine receptor 2 (CXCR2), a specific receptor for interleukin-8 and neutrophil chemoattractant, plays an important role. The first aim of this study was to investigate the CXCR2 gene variability in chronic periodontitis (CP) patients and healthy nonperiodontitis controls in the Czech population. The second aim was to find a relation between CXCR2 gene variants and the presence of periodontal bacteria. A total of 500 unrelated subjects participated in this case-control study. 329 CP patients and 171 healthy nonperiodontitis controls were analyzed using polymerase chain reaction techniques for three single-nucleotide polymorphisms (SNPs): +785C/T (rs2230054), +1208T/C (rs1126579), and +1440A/G (rs1126580). A DNA microarray detection kit was used for the investigation of the subgingival bacterial colonization, in a subgroup of CP subjects (N=162). No significant differences in allele, genotype, haplotype, or haplogenotype frequencies of CXCR2 gene variants between patients with CP and healthy controls (P>0.05) were determined. Nevertheless, Aggregatibacter actinomycetemcomitans was detected more frequently in men positive for the C allele of the CXCR2 +785C/T polymorphism (61.8% vs. 41.1%, P<0.05; OR=2.31, 95% CI=1.03-5.20) and for the T allele of the CXCR2 +1208C/T variant (61.8% vs. 38.9%, P<0.05; OR=2.54, 95% CI=1.13-5.71). In contrast, no statistically significant associations of CXCR2 variants with seven selected periodontal bacteria were found in women. Although none of the investigated SNPs in the CXCR2 gene was associated with CP, the CXCR2 gene variants can be associated with subgingival colonization of G- bacteria in men with CP in the Czech population.

Links

GB14-37368G, research and development project

Name: Centrum orofaciálního vývoje a regenerace

Investor: Czech Science Foundation

MUNI/A/1008/2017, interní kód MU

Name: Etiopatogenetické aspekty, diagnostika a léčba vybraných onemocnění dutiny ústní

Investor: Masaryk University, Category A

ROZV/25/LF/2017, interní kód MU

Name: LF - Příspěvek na IP 2017

Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects

Citovat

KAVŘÍKOVÁ, Denisa, Petra BOŘILOVÁ LINHARTOVÁ, Světlana LUČANOVÁ, Hana POSKEROVÁ, Antonín FASSMANN and Lydie IZAKOVIČOVÁ HOLLÁ. Chemokine Receptor 2 (CXCR2) Gene Variants and Their Association with Periodontal Bacteria in Patients with Chronic Periodontitis. MEDIATORS OF INFLAMMATION. London: HINDAWI LTD, 2019, vol. 2019, No 2061868, p. 1-8. ISSN 0962-9351. Available from: https://dx.doi.org/10.1155/2019/2061868.

@article{1517516,
   author = {Kavříková, Denisa and Bořilová Linhartová, Petra and Lučanová, Světlana and Poskerová, Hana and Fassmann, Antonín and Izakovičová Hollá, Lydie},
   article_location = {London},
   article_number = {2061868},
   doi = {http://dx.doi.org/10.1155/2019/2061868},
   keywords = {Periodontitis},
   language = {eng},
   issn = {0962-9351},
   journal = {MEDIATORS OF INFLAMMATION},
   title = {Chemokine Receptor 2 (CXCR2) Gene Variants and Their Association with Periodontal Bacteria in Patients with Chronic Periodontitis},
   url = {http://dx.doi.org/10.1155/2019/2061868},
   volume = {2019},
   year = {2019}
}

TY  - JOUR
ID  - 1517516
AU  - Kavříková, Denisa - Bořilová Linhartová, Petra - Lučanová, Světlana - Poskerová, Hana - Fassmann, Antonín - Izakovičová Hollá, Lydie
PY  - 2019
TI  - Chemokine Receptor 2 (CXCR2) Gene Variants and Their Association with Periodontal Bacteria in Patients with Chronic Periodontitis
JF  - MEDIATORS OF INFLAMMATION
VL  - 2019
IS  - 2061868
SP  - 1-8
EP  - 1-8
PB  - HINDAWI LTD
SN  - 09629351
KW  - Periodontitis
UR  - http://dx.doi.org/10.1155/2019/2061868
L2  - http://dx.doi.org/10.1155/2019/2061868
N2  - Periodontitis, an inflammatory disease caused by subgingival Gram-negative (G-) bacteria, is linked with loss of the connective tissue and destruction of the alveolar bone. In the regulation of inflammatory response, chemokine receptor 2 (CXCR2), a specific receptor for interleukin-8 and neutrophil chemoattractant, plays an important role. The first aim of this study was to investigate the CXCR2 gene variability in chronic periodontitis (CP) patients and healthy nonperiodontitis controls in the Czech population. The second aim was to find a relation between CXCR2 gene variants and the presence of periodontal bacteria. A total of 500 unrelated subjects participated in this case-control study. 329 CP patients and 171 healthy nonperiodontitis controls were analyzed using polymerase chain reaction techniques for three single-nucleotide polymorphisms (SNPs): +785C/T (rs2230054), +1208T/C (rs1126579), and +1440A/G (rs1126580). A DNA microarray detection kit was used for the investigation of the subgingival bacterial colonization, in a subgroup of CP subjects (N=162). No significant differences in allele, genotype, haplotype, or haplogenotype frequencies of CXCR2 gene variants between patients with CP and healthy controls (P>0.05) were determined. Nevertheless, Aggregatibacter actinomycetemcomitans was detected more frequently in men positive for the C allele of the CXCR2 +785C/T polymorphism (61.8% vs. 41.1%, P<0.05; OR=2.31, 95% CI=1.03-5.20) and for the T allele of the CXCR2 +1208C/T variant (61.8% vs. 38.9%, P<0.05; OR=2.54, 95% CI=1.13-5.71). In contrast, no statistically significant associations of CXCR2 variants with seven selected periodontal bacteria were found in women. Although none of the investigated SNPs in the CXCR2 gene was associated with CP, the CXCR2 gene variants can be associated with subgingival colonization of G- bacteria in men with CP in the Czech population.
ER  -

KAVŘÍKOVÁ, Denisa, Petra BOŘILOVÁ LINHARTOVÁ, Světlana LUČANOVÁ, Hana POSKEROVÁ, Antonín FASSMANN and Lydie IZAKOVIČOVÁ HOLLÁ. Chemokine Receptor 2 (CXCR2) Gene Variants and Their Association with Periodontal Bacteria in Patients with Chronic Periodontitis. \textit{MEDIATORS OF INFLAMMATION}. London: HINDAWI LTD, 2019, vol.~2019, No~2061868, p.~1-8. ISSN~0962-9351. Available from: https://dx.doi.org/10.1155/2019/2061868.

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