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@proceedings{1518456,
author = {Fujdiarová, Eva and Houser, Josef and Wimmerová, Michaela},
booktitle = {XVI Discussions in Structural Molecular Biology},
keywords = {methylation; lectins; saccharides; Photorhabdus},
language = {eng},
title = {Infulence of glucose 3-O-methylation on binding properties towards PLL2 lectin},
year = {2019}
}
TY - CONF
ID - 1518456
AU - Fujdiarová, Eva - Houser, Josef - Wimmerová, Michaela
PY - 2019
TI - Infulence of glucose 3-O-methylation on binding properties towards PLL2 lectin
KW - methylation
KW - lectins
KW - saccharides
KW - Photorhabdus
N2 - In protein-sugar interaction, the sugar OH groups are generally considered as the main interacting groups participating in ligand binding via hydrogen bonds. However, recent findings demonstrate the importance of non-polar interactions, such as CH-PI interactions between aromatic amino acids and apolar part of carbohydrate molecules. One of the modifications which increase the hydrophobicity of the molecule is O-methylation. O-methylation of sugars is an uncommon modification with not fully understood function. Recently, it was described as a pathogen-associated molecular pattern (PAMP) recognized during innate immune response. In order to assess the role of O-methyl groups on sugar recognition, we determined a structure of bacterial lectin PLL2 in complex with d-glucose (d-Glc) or 3-O-methyl-d-glucose (3OMG), respectively .
ER -
FUJDIAROVÁ, Eva, Josef HOUSER and Michaela WIMMEROVÁ. Infulence of glucose 3-O-methylation on binding properties towards PLL2 lectin. In \textit{XVI Discussions in Structural Molecular Biology}. 2019.
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