| KAISER, Karol, D. GYLLBORG, J. PROCHAZKA, Alena SALAŠOVÁ, Petra KOMPANÍKOVÁ, F.L. MOLINA, R. LAGUNA-GOYA, Tomasz Witold RADASZKIEWICZ, Jakub HARNOŠ, M. PROCHAZKOVA, David POTĚŠIL, R.A. BARKER, A.G. CASADO, Zbyněk ZDRÁHAL, R. SEDLACEK, E. ARENAS, Juan Carlos VILLAESCUSA and Vítězslav BRYJA. WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis. Nature Communications. London: Nature Publishing Group, 2019, vol. 10, No 1, p. 1-15. ISSN 2041-1723. Available from: https://dx.doi.org/10.1038/s41467-019-09298-4. |
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@article{1519376,
author = {Kaiser, Karol and Gyllborg, D. and Prochazka, J. and Salašová, Alena and Kompaníková, Petra and Molina, F.L. and LagunaandGoya, R. and Radaszkiewicz, Tomasz Witold and Harnoš, Jakub and Prochazkova, M. and Potěšil, David and Barker, R.A. and Casado, A.G. and Zdráhal, Zbyněk and Sedlacek, R. and Arenas, E. and Villaescusa, Juan Carlos and Bryja, Vítězslav},
article_location = {London},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41467-019-09298-4},
keywords = {LOW-DENSITY LIPOPROTEINS; CELLS; PROTEINS; RECEPTOR; EXPRESSION; MUTATIONS; SECRETION; PROTEOME; HEDGEHOG; SYSTEM},
language = {eng},
issn = {2041-1723},
journal = {Nature Communications},
title = {WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis},
url = {https://www.nature.com/articles/s41467-019-09298-4},
volume = {10},
year = {2019}
}
TY - JOUR
ID - 1519376
AU - Kaiser, Karol - Gyllborg, D. - Prochazka, J. - Salašová, Alena - Kompaníková, Petra - Molina, F.L. - Laguna-Goya, R. - Radaszkiewicz, Tomasz Witold - Harnoš, Jakub - Prochazkova, M. - Potěšil, David - Barker, R.A. - Casado, A.G. - Zdráhal, Zbyněk - Sedlacek, R. - Arenas, E. - Villaescusa, Juan Carlos - Bryja, Vítězslav
PY - 2019
TI - WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis
JF - Nature Communications
VL - 10
IS - 1
SP - 1-15
EP - 1-15
PB - Nature Publishing Group
SN - 20411723
KW - LOW-DENSITY LIPOPROTEINS
KW - CELLS
KW - PROTEINS
KW - RECEPTOR
KW - EXPRESSION
KW - MUTATIONS
KW - SECRETION
KW - PROTEOME
KW - HEDGEHOG
KW - SYSTEM
UR - https://www.nature.com/articles/s41467-019-09298-4
L2 - https://www.nature.com/articles/s41467-019-09298-4
N2 - WNTs are lipid-modified proteins that control multiple functions in development and disease via short- and long-range signaling. However, it is unclear how these hydrophobic molecules spread over long distances in the mammalian brain. Here we show that WNT5A is produced by the choroid plexus (ChP) of the developing hindbrain, but not the telencephalon, in both mouse and human. Since the ChP produces and secretes the cerebrospinal fluid (CSF), we examine the presence of WNT5A in the CSF and find that it is associated with lipoprotein particles rather than exosomes. Moreover, since the CSF flows along the apical surface of hindbrain progenitors not expressing Wnt5a, we examined whether deletion of Wnt5a in the ChP controls their function and find that cerebellar morphogenesis is impaired. Our study thus identifies the CSF as a route and lipoprotein particles as a vehicle for long-range transport of biologically active WNT in the central nervous system.
ER -
KAISER, Karol, D. GYLLBORG, J. PROCHAZKA, Alena SALAŠOVÁ, Petra KOMPANÍKOVÁ, F.L. MOLINA, R. LAGUNA-GOYA, Tomasz Witold RADASZKIEWICZ, Jakub HARNOŠ, M. PROCHAZKOVA, David POTĚŠIL, R.A. BARKER, A.G. CASADO, Zbyněk ZDRÁHAL, R. SEDLACEK, E. ARENAS, Juan Carlos VILLAESCUSA and Vítězslav BRYJA. WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis. \textit{Nature Communications}. London: Nature Publishing Group, 2019, vol.~10, No~1, p.~1-15. ISSN~2041-1723. Available from: https://dx.doi.org/10.1038/s41467-019-09298-4.
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