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@article{1520977,
author = {Raudenská, Martina and Kratochvílová, Monika and Vičar, Tomáš and Gumulec, Jaromír and Balvan, Jan and Polanská, Hana and Přibyl, Jan and Masařík, Michal},
article_location = {London},
article_number = {1660},
doi = {http://dx.doi.org/10.1038/s41598-018-38199-7},
keywords = {prostate cancer cells},
language = {eng},
issn = {2045-2322},
journal = {Scientific reports},
title = {Cisplatin enhances cell stiffness and decreases invasiveness rate in prostate cancer cells by actin accumulation},
url = {https://www.nature.com/articles/s41598-018-38199-7},
volume = {9},
year = {2019}
}
TY - JOUR
ID - 1520977
AU - Raudenská, Martina - Kratochvílová, Monika - Vičar, Tomáš - Gumulec, Jaromír - Balvan, Jan - Polanská, Hana - Přibyl, Jan - Masařík, Michal
PY - 2019
TI - Cisplatin enhances cell stiffness and decreases invasiveness rate in prostate cancer cells by actin accumulation
JF - Scientific reports
VL - 9
IS - 1660
SP - 1-11
EP - 1-11
PB - NATURE PUBLISHING GROUP
SN - 20452322
KW - prostate cancer cells
UR - https://www.nature.com/articles/s41598-018-38199-7
L2 - https://www.nature.com/articles/s41598-018-38199-7
N2 - We focused on the biomechanical and morphological characteristics of prostate cancer cells and their changes resulting from the effect of docetaxel, cisplatin, and long-term zinc supplementation. Cell population surviving the treatment was characterized as follows: cell stiffness was assessed by atomic force microscopy, cell motility and invasion capacity were determined by colony forming assay, wound healing assay, coherence-controlled holographic microscopy, and real-time cell analysis. Cells of metastatic origin exhibited lower height than cells derived from the primary tumour. Cell dry mass and CAV1 gene expression followed similar trends as cell stiffness. Docetaxel-and cisplatin-surviving cells had higher stiffness, and decreased motility and invasive potential as compared to non-treated cells. This effect was not observed in zinc(II)-treated cells. We presume that cell stiffness changes may represent an important overlooked effect of cisplatin-based anti-cancer drugs. Atomic force microscopy and confocal microscopy data images used in our study are available for download in the Zenodo repository.
ER -
RAUDENSKÁ, Martina, Monika KRATOCHVÍLOVÁ, Tomáš VIČAR, Jaromír GUMULEC, Jan BALVAN, Hana POLANSKÁ, Jan PŘIBYL a Michal MASAŘÍK. Cisplatin enhances cell stiffness and decreases invasiveness rate in prostate cancer cells by actin accumulation. \textit{Scientific reports}. London: NATURE PUBLISHING GROUP, roč.~9, č.~1660, s.~1-11. ISSN~2045-2322. doi:10.1038/s41598-018-38199-7. 2019.
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