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@article{1521096,
author = {Horáková, Magda and Martinka, I. and Voháňka, Stanislav and Špalek, P. and Bednařík, Josef},
article_location = {Praha},
article_number = {2},
doi = {http://dx.doi.org/10.14735/amcsnn2019171},
keywords = {myasthenia gravis; population characteristics; comparison; registries},
language = {eng},
issn = {1210-7859},
journal = {Česká a slovenská neurologie a neurochirurgie},
title = {A comparative study of myasthenic patients in the Czech and Slovak Republics},
url = {http://dx.doi.org/10.14735/amcsnn2019171},
volume = {82},
year = {2019}
}
TY - JOUR
ID - 1521096
AU - Horáková, Magda - Martinka, I. - Voháňka, Stanislav - Špalek, P. - Bednařík, Josef
PY - 2019
TI - A comparative study of myasthenic patients in the Czech and Slovak Republics
JF - Česká a slovenská neurologie a neurochirurgie
VL - 82
IS - 2
SP - 171-175
EP - 171-175
PB - Česká lékařská společnost J.E. Purkyně
SN - 12107859
KW - myasthenia gravis
KW - population characteristics
KW - comparison
KW - registries
UR - http://dx.doi.org/10.14735/amcsnn2019171
L2 - http://dx.doi.org/10.14735/amcsnn2019171
N2 - Aim: Existing epidemiological studies of myasthenia feature differences in incidence, prevalence, age-and gender-specific incidences, mortality rate, and even the prevalence of myasthenia subtypes. The aim of this study was to compare the over all management of patients with myasthenia, the severity of the disease, and a number of clinical and laboratory characteristics and therapy approaches amongst patients in the Czech Republic and the Slovak Republic. Patients and methods: Data were retrospectively collected from two registries in the Czech Republic (Brno) and the Slovak Republic (Bratislava). Data were randomly matched by age of onset of myasthenia and gender. The resulting groups consisted of 152 patients each. Results: There was almost no significant difference between the matched groups. The clinical form, positivity of antibodies to acetylcholine receptor, Myasthenia Gravis Composite Score, time to diagnosis, and percentage of thymomas and thymectomy were not significantly different. There were significant differences only in the occurrence of limb weakness at the onset of disease and in the choice of treatment modality. Conclusions: Our data suggest that at least part of previously observed heterogeneity between populations might be based on different age and gender distribution.
ER -
HORÁKOVÁ, Magda, I. MARTINKA, Stanislav VOHÁŇKA, P. ŠPALEK and Josef BEDNAŘÍK. A comparative study of myasthenic patients in the Czech and Slovak Republics. \textit{Česká a slovenská neurologie a neurochirurgie}. Praha: Česká lékařská společnost J.E. Purkyně, 2019, vol.~82, No~2, p.~171-175. ISSN~1210-7859. Available from: https://dx.doi.org/10.14735/amcsnn2019171.
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