A comparative study of myasthenic patients in the Czech and
Slovak Republics

J 2019

A comparative study of myasthenic patients in the Czech and Slovak Republics

HORÁKOVÁ, Magda, I. MARTINKA, Stanislav VOHÁŇKA, P. ŠPALEK, Josef BEDNAŘÍK et. al.

Basic information

Original name

A comparative study of myasthenic patients in the Czech and Slovak Republics

Name in Czech

Srovnávací studie pacientů s myastenií České a Slovenské republiky

Authors

HORÁKOVÁ, Magda (203 Czech Republic, guarantor, belonging to the institution), I. MARTINKA (703 Slovakia), Stanislav VOHÁŇKA (203 Czech Republic, belonging to the institution), P. ŠPALEK (703 Slovakia) and Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution)

Edition

Česká a slovenská neurologie a neurochirurgie, Praha, Česká lékařská společnost J.E. Purkyně, 2019, 1210-7859

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 0.377

RIV identification code

RIV/00216224:14110/19:00109453

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.14735/amcsnn2019171

UT WoS

000462991800006

Keywords in English

myasthenia gravis; population characteristics; comparison; registries

Abstract

V originále

Aim: Existing epidemiological studies of myasthenia feature differences in incidence, prevalence, age-and gender-specific incidences, mortality rate, and even the prevalence of myasthenia subtypes. The aim of this study was to compare the over all management of patients with myasthenia, the severity of the disease, and a number of clinical and laboratory characteristics and therapy approaches amongst patients in the Czech Republic and the Slovak Republic. Patients and methods: Data were retrospectively collected from two registries in the Czech Republic (Brno) and the Slovak Republic (Bratislava). Data were randomly matched by age of onset of myasthenia and gender. The resulting groups consisted of 152 patients each. Results: There was almost no significant difference between the matched groups. The clinical form, positivity of antibodies to acetylcholine receptor, Myasthenia Gravis Composite Score, time to diagnosis, and percentage of thymomas and thymectomy were not significantly different. There were significant differences only in the occurrence of limb weakness at the onset of disease and in the choice of treatment modality. Conclusions: Our data suggest that at least part of previously observed heterogeneity between populations might be based on different age and gender distribution.

Links

ROZV/25/LF/2017, interní kód MU

Name: LF - Příspěvek na IP 2017

Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects

Citovat

HORÁKOVÁ, Magda, I. MARTINKA, Stanislav VOHÁŇKA, P. ŠPALEK and Josef BEDNAŘÍK. A comparative study of myasthenic patients in the Czech and Slovak Republics. Česká a slovenská neurologie a neurochirurgie. Praha: Česká lékařská společnost J.E. Purkyně, 2019, vol. 82, No 2, p. 171-175. ISSN 1210-7859. Available from: https://dx.doi.org/10.14735/amcsnn2019171.

@article{1521096,
   author = {Horáková, Magda and Martinka, I. and Voháňka, Stanislav and Špalek, P. and Bednařík, Josef},
   article_location = {Praha},
   article_number = {2},
   doi = {http://dx.doi.org/10.14735/amcsnn2019171},
   keywords = {myasthenia gravis; population characteristics; comparison; registries},
   language = {eng},
   issn = {1210-7859},
   journal = {Česká a slovenská neurologie a neurochirurgie},
   title = {A comparative study of myasthenic patients in the Czech and Slovak Republics},
   url = {http://dx.doi.org/10.14735/amcsnn2019171},
   volume = {82},
   year = {2019}
}

TY  - JOUR
ID  - 1521096
AU  - Horáková, Magda - Martinka, I. - Voháňka, Stanislav - Špalek, P. - Bednařík, Josef
PY  - 2019
TI  - A comparative study of myasthenic patients in the Czech and Slovak Republics
JF  - Česká a slovenská neurologie a neurochirurgie
VL  - 82
IS  - 2
SP  - 171-175
EP  - 171-175
PB  - Česká lékařská společnost J.E. Purkyně
SN  - 12107859
KW  - myasthenia gravis
KW  - population characteristics
KW  - comparison
KW  - registries
UR  - http://dx.doi.org/10.14735/amcsnn2019171
L2  - http://dx.doi.org/10.14735/amcsnn2019171
N2  - Aim: Existing epidemiological studies of myasthenia feature differences in incidence, prevalence, age-and gender-specific incidences, mortality rate, and even the prevalence of myasthenia subtypes. The aim of this study was to compare the over all management of patients with myasthenia, the severity of the disease, and a number of clinical and laboratory characteristics and therapy approaches amongst patients in the Czech Republic and the Slovak Republic. Patients and methods: Data were retrospectively collected from two registries in the Czech Republic (Brno) and the Slovak Republic (Bratislava). Data were randomly matched by age of onset of myasthenia and gender. The resulting groups consisted of 152 patients each. Results: There was almost no significant difference between the matched groups. The clinical form, positivity of antibodies to acetylcholine receptor, Myasthenia Gravis Composite Score, time to diagnosis, and percentage of thymomas and thymectomy were not significantly different. There were significant differences only in the occurrence of limb weakness at the onset of disease and in the choice of treatment modality. Conclusions: Our data suggest that at least part of previously observed heterogeneity between populations might be based on different age and gender distribution.
ER  -

HORÁKOVÁ, Magda, I. MARTINKA, Stanislav VOHÁŇKA, P. ŠPALEK and Josef BEDNAŘÍK. A comparative study of myasthenic patients in the Czech and Slovak Republics. \textit{Česká a slovenská neurologie a neurochirurgie}. Praha: Česká lékařská společnost J.E. Purkyně, 2019, vol.~82, No~2, p.~171-175. ISSN~1210-7859. Available from: https://dx.doi.org/10.14735/amcsnn2019171.

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