The impact of NF-kappa B signaling on pathogenesis and current treatment strategies in multiple myeloma

VRÁBEL, Dávid, Luděk POUR and Sabina ŠEVČÍKOVÁ. The impact of NF-kappa B signaling on pathogenesis and current treatment strategies in multiple myeloma. BLOOD REVIEWS. EDINBURGH: CHURCHILL LIVINGSTONE, 2019, vol. 34, MAR 2019, p. 56-66. ISSN 0268-960X. Available from: https://dx.doi.org/10.1016/j.blre.2018.11.003.

Basic information

• Original name: The impact of NF-kappa B signaling on pathogenesis and current treatment strategies in multiple myeloma
• Authors: VRÁBEL, Dávid (703 Slovakia, belonging to the institution), Luděk POUR (203 Czech Republic) and Sabina ŠEVČÍKOVÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: BLOOD REVIEWS, EDINBURGH, CHURCHILL LIVINGSTONE, 2019, 0268-960X.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30205 Hematology
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 5.823
• RIV identification code: RIV/00216224:14110/19:00108461
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1016/j.blre.2018.11.003
• UT WoS: 000459839600006
• Keywords in English: Multiple myeloma; Bone marrow; NF-kappa B; Therapy; Proteasome inhibitor
• Tags: 14110518, rivok
• Tags: International impact, Reviewed

Abstract

Multiple myeloma, which ranks as the second most common hematological malignancy, is known for its great genetic heterogeneity. One pathway, however, stands out in this diverse group. NF-kappa B pathway is one of the most important pathways in multiple myeloma not only for its role in pathogenesis, but also for its importance in various treatment strategies. Mutations in several major components of the NF-kappa B pathway and its regulators are present in at least 17% of primary multiple myeloma tumors and 42% of multiple myeloma cell lines. The NF-kappa B pathway regulates numerous genes, which influence development and pathogenesis of multiple myeloma. This significance of NF-kappa B for myeloma cells, however, is used against them, as current treatment strategies often use NF-kappa B as their primary or secondary target.

Links

• NV15-29508A, research and development project: Name: Cirkulující nukleové kyseliny jako markery progrese mnohočetného myelomu