The impact of NF-kappa B signaling on pathogenesis and current
treatment strategies in multiple myeloma

J 2019

The impact of NF-kappa B signaling on pathogenesis and current treatment strategies in multiple myeloma

VRÁBEL, Dávid, Luděk POUR and Sabina ŠEVČÍKOVÁ

Basic information

Original name

The impact of NF-kappa B signaling on pathogenesis and current treatment strategies in multiple myeloma

Authors

VRÁBEL, Dávid (703 Slovakia, belonging to the institution), Luděk POUR (203 Czech Republic) and Sabina ŠEVČÍKOVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

BLOOD REVIEWS, EDINBURGH, CHURCHILL LIVINGSTONE, 2019, 0268-960X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30205 Hematology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.823

RIV identification code

RIV/00216224:14110/19:00108461

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.blre.2018.11.003

UT WoS

000459839600006

Keywords in English

Multiple myeloma; Bone marrow; NF-kappa B; Therapy; Proteasome inhibitor

Abstract

V originále

Multiple myeloma, which ranks as the second most common hematological malignancy, is known for its great genetic heterogeneity. One pathway, however, stands out in this diverse group. NF-kappa B pathway is one of the most important pathways in multiple myeloma not only for its role in pathogenesis, but also for its importance in various treatment strategies. Mutations in several major components of the NF-kappa B pathway and its regulators are present in at least 17% of primary multiple myeloma tumors and 42% of multiple myeloma cell lines. The NF-kappa B pathway regulates numerous genes, which influence development and pathogenesis of multiple myeloma. This significance of NF-kappa B for myeloma cells, however, is used against them, as current treatment strategies often use NF-kappa B as their primary or secondary target.

Links

NV15-29508A, research and development project

Name: Cirkulující nukleové kyseliny jako markery progrese mnohočetného myelomu

Citovat

VRÁBEL, Dávid, Luděk POUR and Sabina ŠEVČÍKOVÁ. The impact of NF-kappa B signaling on pathogenesis and current treatment strategies in multiple myeloma. BLOOD REVIEWS. EDINBURGH: CHURCHILL LIVINGSTONE, 2019, vol. 34, MAR 2019, p. 56-66. ISSN 0268-960X. Available from: https://dx.doi.org/10.1016/j.blre.2018.11.003.

@article{1521696,
   author = {Vrábel, Dávid and Pour, Luděk and Ševčíková, Sabina},
   article_location = {EDINBURGH},
   article_number = {MAR 2019},
   doi = {http://dx.doi.org/10.1016/j.blre.2018.11.003},
   keywords = {Multiple myeloma; Bone marrow; NF-kappa B; Therapy; Proteasome inhibitor},
   language = {eng},
   issn = {0268-960X},
   journal = {BLOOD REVIEWS},
   title = {The impact of NF-kappa B signaling on pathogenesis and current treatment strategies in multiple myeloma},
   url = {http://dx.doi.org/10.1016/j.blre.2018.11.003},
   volume = {34},
   year = {2019}
}

TY  - JOUR
ID  - 1521696
AU  - Vrábel, Dávid - Pour, Luděk - Ševčíková, Sabina
PY  - 2019
TI  - The impact of NF-kappa B signaling on pathogenesis and current treatment strategies in multiple myeloma
JF  - BLOOD REVIEWS
VL  - 34
IS  - MAR 2019
SP  - 56-66
EP  - 56-66
PB  - CHURCHILL LIVINGSTONE
SN  - 0268960X
KW  - Multiple myeloma
KW  - Bone marrow
KW  - NF-kappa B
KW  - Therapy
KW  - Proteasome inhibitor
UR  - http://dx.doi.org/10.1016/j.blre.2018.11.003
L2  - http://dx.doi.org/10.1016/j.blre.2018.11.003
N2  - Multiple myeloma, which ranks as the second most common hematological malignancy, is known for its great genetic heterogeneity. One pathway, however, stands out in this diverse group. NF-kappa B pathway is one of the most important pathways in multiple myeloma not only for its role in pathogenesis, but also for its importance in various treatment strategies. Mutations in several major components of the NF-kappa B pathway and its regulators are present in at least 17% of primary multiple myeloma tumors and 42% of multiple myeloma cell lines. The NF-kappa B pathway regulates numerous genes, which influence development and pathogenesis of multiple myeloma. This significance of NF-kappa B for myeloma cells, however, is used against them, as current treatment strategies often use NF-kappa B as their primary or secondary target.
ER  -

VRÁBEL, Dávid, Luděk POUR and Sabina ŠEVČÍKOVÁ. The impact of NF-kappa B signaling on pathogenesis and current treatment strategies in multiple myeloma. \textit{BLOOD REVIEWS}. EDINBURGH: CHURCHILL LIVINGSTONE, 2019, vol.~34, MAR 2019, p.~56-66. ISSN~0268-960X. Available from: https://dx.doi.org/10.1016/j.blre.2018.11.003.

Detailed Information on Publication Record