Consensus paper: Decoding the Contributions of the Cerebellum
as a Time Machine. From Neurons to Clinical Applications

J 2019

Consensus paper: Decoding the Contributions of the Cerebellum as a Time Machine. From Neurons to Clinical Applications

BAREŠ, Martin, Richard APPS, Laura AVANZINO, Assaf BRESKA, Edigio D ANGELO et. al.

Basic information

Original name

Consensus paper: Decoding the Contributions of the Cerebellum as a Time Machine. From Neurons to Clinical Applications

Authors

BAREŠ, Martin (203 Czech Republic, guarantor, belonging to the institution), Richard APPS (826 United Kingdom of Great Britain and Northern Ireland), Laura AVANZINO (380 Italy), Assaf BRESKA (840 United States of America), Edigio D ANGELO (380 Italy), Pavel FILIP (703 Slovakia, belonging to the institution), Marcus GERWIG (276 Germany), Richard B. IVRY (840 United States of America), Charlotte L. LAWRENSON (826 United Kingdom of Great Britain and Northern Ireland), Elan D. LOUIS (840 United States of America), Nicholas A. LUSK (840 United States of America), Mario MANTO (56 Belgium), Warren H. MECK (840 United States of America), Hiroshi MITOMA (392 Japan) and Elijah A. PETTER (840 United States of America)

Edition

Cerebellum, New York, Springer, 2019, 1473-4222

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.129

RIV identification code

RIV/00216224:14110/19:00109467

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s12311-018-0979-5

UT WoS

000463032900013

Keywords in English

Cerebellum; Timing; Consensus; Temporal processing; Movement; Climbing fiber

Abstract

V originále

Time perception is an essential element of conscious and subconscious experience, coordinating our perception and interaction with the surrounding environment. In recent years, major technological advances in the field of neuroscience have helped foster new insights into the processing of temporal information, including extending our knowledge of the role of the cerebellum as one of the key nodes in the brain for this function. This consensus paper provides a state-of-the-art picture from the experts in the field of the cerebellar research on a variety of crucial issues related to temporal processing, drawing on recent anatomical, neurophysiological, behavioral, and clinical research.The cerebellar granular layer appears especially well-suited for timing operations required to confer millisecond precision for cerebellar computations. This may be most evident in the manner the cerebellum controls the duration of the timing of agonist-antagonist EMG bursts associated with fast goal-directed voluntary movements. In concert with adaptive processes, interactions within the cerebellar cortex are sufficient to support sub-second timing. However, supra-second timing seems to require cortical and basal ganglia networks, perhaps operating in concert with cerebellum. Additionally, sensory information such as an unexpected stimulus can be forwarded to the cerebellum via the climbing fiber system, providing a temporally constrained mechanism to adjust ongoing behavior and modify future processing. Patients with cerebellar disorders exhibit impairments on a range of tasks that require precise timing, and recent evidence suggest that timing problems observed in other neurological conditions such as Parkinson's disease, essential tremor, and dystonia may reflect disrupted interactions between the basal ganglia and cerebellum.The complex concepts emerging from this consensus paper should provide a foundation for further discussion, helping identify basic research questions required to understand how the brain represents and utilizes time, as well as delineating ways in which this knowledge can help improve the lives of those with neurological conditions that disrupt this most elemental sense. The panel of experts agrees that timing control in the brain is a complex concept in whom cerebellar circuitry is deeply involved. The concept of a timing machine has now expanded to clinical disorders.

Citovat

BAREŠ, Martin, Richard APPS, Laura AVANZINO, Assaf BRESKA, Edigio D ANGELO, Pavel FILIP, Marcus GERWIG, Richard B. IVRY, Charlotte L. LAWRENSON, Elan D. LOUIS, Nicholas A. LUSK, Mario MANTO, Warren H. MECK, Hiroshi MITOMA and Elijah A. PETTER. Consensus paper: Decoding the Contributions of the Cerebellum as a Time Machine. From Neurons to Clinical Applications. Cerebellum. New York: Springer, 2019, vol. 18, No 2, p. 266-286. ISSN 1473-4222. Available from: https://dx.doi.org/10.1007/s12311-018-0979-5.

@article{1521716,
   author = {Bareš, Martin and Apps, Richard and Avanzino, Laura and Breska, Assaf and D Angelo, Edigio and Filip, Pavel and Gerwig, Marcus and Ivry, Richard B. and Lawrenson, Charlotte L. and Louis, Elan D. and Lusk, Nicholas A. and Manto, Mario and Meck, Warren H. and Mitoma, Hiroshi and Petter, Elijah A.},
   article_location = {New York},
   article_number = {2},
   doi = {http://dx.doi.org/10.1007/s12311-018-0979-5},
   keywords = {Cerebellum; Timing; Consensus; Temporal processing; Movement; Climbing fiber},
   language = {eng},
   issn = {1473-4222},
   journal = {Cerebellum},
   title = {Consensus paper: Decoding the Contributions of the Cerebellum as a Time Machine. From Neurons to Clinical Applications},
   url = {http://dx.doi.org/10.1007/s12311-018-0979-5},
   volume = {18},
   year = {2019}
}

TY  - JOUR
ID  - 1521716
AU  - Bareš, Martin - Apps, Richard - Avanzino, Laura - Breska, Assaf - D Angelo, Edigio - Filip, Pavel - Gerwig, Marcus - Ivry, Richard B. - Lawrenson, Charlotte L. - Louis, Elan D. - Lusk, Nicholas A. - Manto, Mario - Meck, Warren H. - Mitoma, Hiroshi - Petter, Elijah A.
PY  - 2019
TI  - Consensus paper: Decoding the Contributions of the Cerebellum as a Time Machine. From Neurons to Clinical Applications
JF  - Cerebellum
VL  - 18
IS  - 2
SP  - 266-286
EP  - 266-286
PB  - Springer
SN  - 14734222
KW  - Cerebellum
KW  - Timing
KW  - Consensus
KW  - Temporal processing
KW  - Movement
KW  - Climbing fiber
UR  - http://dx.doi.org/10.1007/s12311-018-0979-5
L2  - http://dx.doi.org/10.1007/s12311-018-0979-5
N2  - Time perception is an essential element of conscious and subconscious experience, coordinating our perception and interaction with the surrounding environment. In recent years, major technological advances in the field of neuroscience have helped foster new insights into the processing of temporal information, including extending our knowledge of the role of the cerebellum as one of the key nodes in the brain for this function. This consensus paper provides a state-of-the-art picture from the experts in the field of the cerebellar research on a variety of crucial issues related to temporal processing, drawing on recent anatomical, neurophysiological, behavioral, and clinical research.The cerebellar granular layer appears especially well-suited for timing operations required to confer millisecond precision for cerebellar computations. This may be most evident in the manner the cerebellum controls the duration of the timing of agonist-antagonist EMG bursts associated with fast goal-directed voluntary movements. In concert with adaptive processes, interactions within the cerebellar cortex are sufficient to support sub-second timing. However, supra-second timing seems to require cortical and basal ganglia networks, perhaps operating in concert with cerebellum. Additionally, sensory information such as an unexpected stimulus can be forwarded to the cerebellum via the climbing fiber system, providing a temporally constrained mechanism to adjust ongoing behavior and modify future processing. Patients with cerebellar disorders exhibit impairments on a range of tasks that require precise timing, and recent evidence suggest that timing problems observed in other neurological conditions such as Parkinson's disease, essential tremor, and dystonia may reflect disrupted interactions between the basal ganglia and cerebellum.The complex concepts emerging from this consensus paper should provide a foundation for further discussion, helping identify basic research questions required to understand how the brain represents and utilizes time, as well as delineating ways in which this knowledge can help improve the lives of those with neurological conditions that disrupt this most elemental sense. The panel of experts agrees that timing control in the brain is a complex concept in whom cerebellar circuitry is deeply involved. The concept of a timing machine has now expanded to clinical disorders.
ER  -

BAREŠ, Martin, Richard APPS, Laura AVANZINO, Assaf BRESKA, Edigio D ANGELO, Pavel FILIP, Marcus GERWIG, Richard B. IVRY, Charlotte L. LAWRENSON, Elan D. LOUIS, Nicholas A. LUSK, Mario MANTO, Warren H. MECK, Hiroshi MITOMA and Elijah A. PETTER. Consensus paper: Decoding the Contributions of the Cerebellum as a Time Machine. From Neurons to Clinical Applications. \textit{Cerebellum}. New York: Springer, 2019, vol.~18, No~2, p.~266-286. ISSN~1473-4222. Available from: https://dx.doi.org/10.1007/s12311-018-0979-5.

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