| FORMÁNEK, Martin, Pavel KOMÍNEK, Debora JANČATOVÁ, Lucia STANÍKOVÁ, Radoslava TOMANOVÁ, Jana VACULOVÁ, Milan URÍK, Ivo ŠLAPÁK a Karol ZELENÍK. Laryngopharyngeal Reflux Is a Potential Risk Factor for Juvenile-Onset Recurrent Respiratory Papillomatosis. Biomed Research International. New York: Hindawi Publishing Corporation, 2019, roč. 2019, č. 1463896, s. 1-5. ISSN 2314-6133. Dostupné z: https://dx.doi.org/10.1155/2019/1463896. |
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@article{1521736,
author = {Formánek, Martin and Komínek, Pavel and Jančatová, Debora and Staníková, Lucia and Tomanová, Radoslava and Vaculová, Jana and Urík, Milan and Šlapák, Ivo and Zeleník, Karol},
article_location = {New York},
article_number = {1463896},
doi = {http://dx.doi.org/10.1155/2019/1463896},
keywords = {laryngopharyngeal reflux; juvenile-onset recurrent respiratory papillomatosis},
language = {eng},
issn = {2314-6133},
journal = {Biomed Research International},
title = {Laryngopharyngeal Reflux Is a Potential Risk Factor for Juvenile-Onset Recurrent Respiratory Papillomatosis},
url = {http://dx.doi.org/10.1155/2019/1463896},
volume = {2019},
year = {2019}
}
TY - JOUR
ID - 1521736
AU - Formánek, Martin - Komínek, Pavel - Jančatová, Debora - Staníková, Lucia - Tomanová, Radoslava - Vaculová, Jana - Urík, Milan - Šlapák, Ivo - Zeleník, Karol
PY - 2019
TI - Laryngopharyngeal Reflux Is a Potential Risk Factor for Juvenile-Onset Recurrent Respiratory Papillomatosis
JF - Biomed Research International
VL - 2019
IS - 1463896
SP - 1-5
EP - 1-5
PB - Hindawi Publishing Corporation
SN - 23146133
KW - laryngopharyngeal reflux
KW - juvenile-onset recurrent respiratory papillomatosis
UR - http://dx.doi.org/10.1155/2019/1463896
L2 - http://dx.doi.org/10.1155/2019/1463896
N2 - Introduction. Human papillomavirus (HPV) causes juvenile-onset recurrent respiratory papillomatosis (JORRP). Although HPV is common in children, the prevalence of JORRP is low. It is likely that other factors contribute to the pathogenesis of JORRP, during either activation or reactivation of a latent HPV infection. There is evidence that laryngopharyngeal reflux (LPR) might be such a risk factor for adult-onset recurrent respiratory papillomatosis. This study investigated if LPR might also be a risk factor for JORRP. Materials and Methods. Children with JORRP of the larynx that required microlaryngoscopy at a tertiary referral hospital were included in this prospective case-series study from November 2015 to November 2017. Using immunohistochemistry, HPV infection and pepsin associated with LPR were diagnosed from laryngeal biopsies. Results. Eleven children (aged 4-14 years) were analyzed. No patient had a history of immunodeficiency or tobacco smoke exposure. All patients underwent at least three previous surgeries due to JORRP and had been vaccinated against HPV in the past. Five children were treated using antivirotics and immunomodulators. The only known maternal risk factor was that three mothers were primiparous. All 11 samples were infected with HPV (type 6 or 11). Pathologic LPR was diagnosed in 5/11 children (45.5%). Conclusion. LPR may be a risk factor for JORRP, contributing to its development by activating or reactivating a latent HPV infection. Results are in accordance with those from our previous study in adults.
ER -
FORMÁNEK, Martin, Pavel KOMÍNEK, Debora JANČATOVÁ, Lucia STANÍKOVÁ, Radoslava TOMANOVÁ, Jana VACULOVÁ, Milan URÍK, Ivo ŠLAPÁK a Karol ZELENÍK. Laryngopharyngeal Reflux Is a Potential Risk Factor for Juvenile-Onset Recurrent Respiratory Papillomatosis. \textit{Biomed Research International}. New York: Hindawi Publishing Corporation, 2019, roč.~2019, č.~1463896, s.~1-5. ISSN~2314-6133. Dostupné z: https://dx.doi.org/10.1155/2019/1463896.
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