Laryngopharyngeal Reflux Is a Potential Risk Factor for Juvenile-Onset Recurrent Respiratory Papillomatosis

FORMÁNEK, Martin, Pavel KOMÍNEK, Debora JANČATOVÁ, Lucia STANÍKOVÁ, Radoslava TOMANOVÁ, Jana VACULOVÁ, Milan URÍK, Ivo ŠLAPÁK and Karol ZELENÍK. Laryngopharyngeal Reflux Is a Potential Risk Factor for Juvenile-Onset Recurrent Respiratory Papillomatosis. Biomed Research International. New York: Hindawi Publishing Corporation, 2019, vol. 2019, No 1463896, p. 1-5. ISSN 2314-6133. Available from: https://dx.doi.org/10.1155/2019/1463896.

Basic information

Original name

Laryngopharyngeal Reflux Is a Potential Risk Factor for Juvenile-Onset Recurrent Respiratory Papillomatosis

Authors

FORMÁNEK, Martin (203 Czech Republic, guarantor), Pavel KOMÍNEK (203 Czech Republic), Debora JANČATOVÁ (203 Czech Republic), Lucia STANÍKOVÁ (203 Czech Republic), Radoslava TOMANOVÁ (203 Czech Republic), Jana VACULOVÁ (203 Czech Republic), Milan URÍK (703 Slovakia, belonging to the institution), Ivo ŠLAPÁK (203 Czech Republic, belonging to the institution) and Karol ZELENÍK (203 Czech Republic)

Edition

Biomed Research International, New York, Hindawi Publishing Corporation, 2019, 2314-6133

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30206 Otorhinolaryngology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.276

RIV identification code

RIV/00216224:14110/19:00109468

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1155/2019/1463896

UT WoS

000459656800001

Keywords in English

laryngopharyngeal reflux; juvenile-onset recurrent respiratory papillomatosis

Tags

14110319, rivok

Tags

International impact, Reviewed

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Abstract

V originále

Introduction. Human papillomavirus (HPV) causes juvenile-onset recurrent respiratory papillomatosis (JORRP). Although HPV is common in children, the prevalence of JORRP is low. It is likely that other factors contribute to the pathogenesis of JORRP, during either activation or reactivation of a latent HPV infection. There is evidence that laryngopharyngeal reflux (LPR) might be such a risk factor for adult-onset recurrent respiratory papillomatosis. This study investigated if LPR might also be a risk factor for JORRP. Materials and Methods. Children with JORRP of the larynx that required microlaryngoscopy at a tertiary referral hospital were included in this prospective case-series study from November 2015 to November 2017. Using immunohistochemistry, HPV infection and pepsin associated with LPR were diagnosed from laryngeal biopsies. Results. Eleven children (aged 4-14 years) were analyzed. No patient had a history of immunodeficiency or tobacco smoke exposure. All patients underwent at least three previous surgeries due to JORRP and had been vaccinated against HPV in the past. Five children were treated using antivirotics and immunomodulators. The only known maternal risk factor was that three mothers were primiparous. All 11 samples were infected with HPV (type 6 or 11). Pathologic LPR was diagnosed in 5/11 children (45.5%). Conclusion. LPR may be a risk factor for JORRP, contributing to its development by activating or reactivating a latent HPV infection. Results are in accordance with those from our previous study in adults.