Quantitative myotonia assessment with a commercially available
dynamometer in myotonic dystrophy types 1 and 2

J 2019

Quantitative myotonia assessment with a commercially available dynamometer in myotonic dystrophy types 1 and 2

HORÁKOVÁ, Magda, Tomáš HORÁK, Olesja PARMOVÁ, Josef BEDNAŘÍK, Stanislav VOHÁŇKA et. al.

Basic information

Original name

Quantitative myotonia assessment with a commercially available dynamometer in myotonic dystrophy types 1 and 2

Authors

HORÁKOVÁ, Magda (203 Czech Republic, guarantor, belonging to the institution), Tomáš HORÁK (203 Czech Republic, belonging to the institution), Olesja PARMOVÁ (203 Czech Republic, belonging to the institution), Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution) and Stanislav VOHÁŇKA (203 Czech Republic, belonging to the institution)

Edition

MUSCLE & NERVE, HOBOKEN, WILEY, 2019, 0148-639X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.505

RIV identification code

RIV/00216224:14110/19:00109475

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1002/mus.26401

UT WoS

000461232700012

Keywords in English

muscle relaxation; muscle strength dynamometer; myotonia; myotonic dystrophy; outcome measure; warm-up

Abstract

V originále

Introduction: The objective of this study was to develop a simple method for quantitative assessment of myotonia in patients with myotonic dystrophy type 1 (DM1) and DM2, to compare the myotonia severity, and to correlate this objective outcome with a subjective scale, the Myotonia Behaviour Scale (MBS). Methods: A commercially available dynamometer was used for all measurements. The relaxation time after voluntary contraction was measured in 20 patients with DM1, 25 patients with DM2, and 35 healthy controls. Results: The average relaxation time was 0.17 s in controls, 2.96 s in patients with DM1, and 0.4 s in patients with DM2. The correlation between relaxation time and MBS score was significant, 0.627 in patients with DM1 and 0.581 in patients with DM2. Discussion: Our method provides a valid and reliable quantitative measure of grip myotonia suitable as an outcome measure in clinical trials and as part of routine examinations to gather data on the natural history of myotonic disorders. Muscle Nerve 59:431-435, 2019

Links

MUNI/A/1072/2017, interní kód MU

Name: Diagnostika a patofyziologie neuropatické bolesti (Acronym: PNB)

Investor: Masaryk University, Category A

MUNI/A/1419/2018, interní kód MU

Name: Diagnostika a patofyziologie neuropatické bolesti (Acronym: PNB)

Investor: Masaryk University, Category A

Citovat

HORÁKOVÁ, Magda, Tomáš HORÁK, Olesja PARMOVÁ, Josef BEDNAŘÍK and Stanislav VOHÁŇKA. Quantitative myotonia assessment with a commercially available dynamometer in myotonic dystrophy types 1 and 2. MUSCLE & NERVE. HOBOKEN: WILEY, 2019, vol. 59, No 4, p. 431-435. ISSN 0148-639X. Available from: https://dx.doi.org/10.1002/mus.26401.

@article{1522136,
   author = {Horáková, Magda and Horák, Tomáš and Parmová, Olesja and Bednařík, Josef and Voháňka, Stanislav},
   article_location = {HOBOKEN},
   article_number = {4},
   doi = {http://dx.doi.org/10.1002/mus.26401},
   keywords = {muscle relaxation; muscle strength dynamometer; myotonia; myotonic dystrophy; outcome measure; warm-up},
   language = {eng},
   issn = {0148-639X},
   journal = {MUSCLE & NERVE},
   title = {Quantitative myotonia assessment with a commercially available dynamometer in myotonic dystrophy types 1 and 2},
   url = {http://dx.doi.org/10.1002/mus.26401},
   volume = {59},
   year = {2019}
}

TY  - JOUR
ID  - 1522136
AU  - Horáková, Magda - Horák, Tomáš - Parmová, Olesja - Bednařík, Josef - Voháňka, Stanislav
PY  - 2019
TI  - Quantitative myotonia assessment with a commercially available dynamometer in myotonic dystrophy types 1 and 2
JF  - MUSCLE & NERVE
VL  - 59
IS  - 4
SP  - 431-435
EP  - 431-435
PB  - WILEY
SN  - 0148639X
KW  - muscle relaxation
KW  - muscle strength dynamometer
KW  - myotonia
KW  - myotonic dystrophy
KW  - outcome measure
KW  - warm-up
UR  - http://dx.doi.org/10.1002/mus.26401
L2  - http://dx.doi.org/10.1002/mus.26401
N2  - Introduction: The objective of this study was to develop a simple method for quantitative assessment of myotonia in patients with myotonic dystrophy type 1 (DM1) and DM2, to compare the myotonia severity, and to correlate this objective outcome with a subjective scale, the Myotonia Behaviour Scale (MBS). Methods: A commercially available dynamometer was used for all measurements. The relaxation time after voluntary contraction was measured in 20 patients with DM1, 25 patients with DM2, and 35 healthy controls. Results: The average relaxation time was 0.17 s in controls, 2.96 s in patients with DM1, and 0.4 s in patients with DM2. The correlation between relaxation time and MBS score was significant, 0.627 in patients with DM1 and 0.581 in patients with DM2. Discussion: Our method provides a valid and reliable quantitative measure of grip myotonia suitable as an outcome measure in clinical trials and as part of routine examinations to gather data on the natural history of myotonic disorders. Muscle Nerve 59:431-435, 2019
ER  -

HORÁKOVÁ, Magda, Tomáš HORÁK, Olesja PARMOVÁ, Josef BEDNAŘÍK and Stanislav VOHÁŇKA. Quantitative myotonia assessment with a commercially available dynamometer in myotonic dystrophy types 1 and 2. \textit{MUSCLE \&{}amp; NERVE}. HOBOKEN: WILEY, 2019, vol.~59, No~4, p.~431-435. ISSN~0148-639X. Available from: https://dx.doi.org/10.1002/mus.26401.

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