Transbronchial biopsy from the upper pulmonary lobes is associated with increased risk of pneumothorax - a retrospective study

HEROUT, Vladimír, Michaela HEROUTOVÁ, Zdeněk MERTA, Ivan ČUNDRLE and Kristián BRAT. Transbronchial biopsy from the upper pulmonary lobes is associated with increased risk of pneumothorax - a retrospective study. BMC Pulmonary Medicine. London: Biomed Central LTD, 2019, vol. 19, No 56, p. 1-6. ISSN 1471-2466. Available from: https://dx.doi.org/10.1186/s12890-019-0820-z.

Basic information

• Original name: Transbronchial biopsy from the upper pulmonary lobes is associated with increased risk of pneumothorax - a retrospective study
• Authors: HEROUT, Vladimír (203 Czech Republic, belonging to the institution), Michaela HEROUTOVÁ (203 Czech Republic, belonging to the institution), Zdeněk MERTA (203 Czech Republic, belonging to the institution), Ivan ČUNDRLE (203 Czech Republic, belonging to the institution) and Kristián BRAT (703 Slovakia, guarantor, belonging to the institution).
• Edition: BMC Pulmonary Medicine, London, Biomed Central LTD, 2019, 1471-2466.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30203 Respiratory systems
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 2.813
• RIV identification code: RIV/00216224:14110/19:00109482
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1186/s12890-019-0820-z
• UT WoS: 000460042200001
• Keywords in English: Pneumothorax; Bronchoscopy; Transbronchial biopsy; Upper pulmonary lobe; Pleural pressure
• Tags: 14110122, 14110215, rivok
• Tags: International impact, Reviewed

Abstract

BackgroundPneumothorax (PTX) is one of the most common complications of transbronchial biopsy (TBB). Previous research suggests that upper pulmonary lobe TBB may be associated with increased risk of PTX development. The aim of this study was to compare the risk of PTX after TBB performed from different pulmonary lobes.MethodsAll bronchoscopic records from the period January 1st, 2015 - December 31st, 2017 (from the Department of Respiratory Diseases, University Hospital Brno, Czech Republic) were retrospectively analyzed. Of the 3542 bronchoscopic records, 796 patients underwent TBB and were further analyzed. Basic demographic data, TBB procedure-related factors, smoking history and radiological features were analyzed. Furthermore, in patients who developed PTX, PTX onset, PTX symptoms, distribution of the abnormal radiological findings and duration of hospitalization were also analyzed.ResultsPatients who developed PTX had significantly lower body mass index (BMI) and more than 4 samples taken during procedure (all p<0.05). TBB performed from the left upper pulmonary lobe was associated with a significant risk of PTX development (OR 2.27; 95% CI 1.18-4.35; p=0.02). On the contrary, TBB performed from the right lower lobe was associated with a significant reduction of risk of developing PTX (OR 0.47; 95% CI 0.22-0.98; p=0.04). Logistic regression analysis showed BMI (OR 1.08; 95% CI 1.02-1.16; p=0.01), left upper lobe as sampling site (OR 2.15; 95% CI 1.13-4.11; p=0.02) and more than 4 samples taken (OR 1.91; 95% CI 1.04-3.49; p=0.04) to be significantly associated with PTX development.ConclusionsWe conclude that TBB from the left upper pulmonary lobe is associated with significantly increased risk of post-procedural PTX. The right lower pulmonary lobe seems to be the safest sampling site to perform TBB. In patients with diffuse-type pulmonary disease, TBB should be performed preferably from the right lower lobe in order to decrease the risk of post-procedural PTX.