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@article{1522757,
author = {Capoor, Manu and Lochman, Jan and McDowell, Andrew and Schmitz, Jonathan E. and Solanský, Martin and Zapletalová, Martina and Alamin, Todd F. and Coscia, Michael F. and Garfin, Steven R. and Jančálek, Radim and Růžička, Filip and Shamie, Nick A. and Smrčka, Martin and Wang, Jeffrey C. and Birkenmaier, Christof and Slabý, Ondřej},
article_location = {NEW YORK},
article_number = {4},
doi = {http://dx.doi.org/10.1007/s00586-018-5838-z},
keywords = {Propionibacterium acnes; Cutibacterium acnes; Degenerative disc disease; Biofilm; Cefazolin; Clindamycin; Vancomycin; Surgical prophylaxis},
language = {eng},
issn = {0940-6719},
journal = {European Spine Journal},
title = {Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections},
url = {https://link.springer.com/content/pdf/10.1007/s00586-018-5838-z.pdf},
volume = {28},
year = {2019}
}
TY - JOUR
ID - 1522757
AU - Capoor, Manu - Lochman, Jan - McDowell, Andrew - Schmitz, Jonathan E. - Solanský, Martin - Zapletalová, Martina - Alamin, Todd F. - Coscia, Michael F. - Garfin, Steven R. - Jančálek, Radim - Růžička, Filip - Shamie, Nick A. - Smrčka, Martin - Wang, Jeffrey C. - Birkenmaier, Christof - Slabý, Ondřej
PY - 2019
TI - Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections
JF - European Spine Journal
VL - 28
IS - 4
SP - 783-791
EP - 783-791
PB - Springer
SN - 09406719
KW - Propionibacterium acnes
KW - Cutibacterium acnes
KW - Degenerative disc disease
KW - Biofilm
KW - Cefazolin
KW - Clindamycin
KW - Vancomycin
KW - Surgical prophylaxis
UR - https://link.springer.com/content/pdf/10.1007/s00586-018-5838-z.pdf
L2 - https://link.springer.com/content/pdf/10.1007/s00586-018-5838-z.pdf
N2 - PurposeThe presence of Propionibacterium acnes in a substantial component of resected disc specimens obtained from patients undergoing discectomy or microdiscectomy has led to the suggestion that this prominent human skin and oral commensal may exacerbate the pathology of degenerative disc disease. This hypothesis, therefore, raises the exciting possibility that antibiotics could play an important role in treating this debilitating condition. To date, however, little information about antibiotic penetration into the intervertebral disc is available. MethodsIntervertebral disc tissue obtained from 54 microdiscectomy patients given prophylactic cefazolin (n=25), clindamycin (n=17) or vancomycin (n=12) was assayed by high-performance liquid chromatography, with cefaclor as an internal standard, to determine the concentration of antibiotic penetrating into the disc tissue.ResultsIntervertebral disc tissues from patients receiving the positively charged antibiotic clindamycin contained a significantly greater percentage of the antibacterial dose than the tissue from patients receiving negatively charged cefazolin (P<0.0001) and vancomycin, which has a slight positive charge (P<0.0001).ConclusionPositively charged antibiotics appear more appropriate for future studies investigating potential options for the treatment of low-virulence disc infections. [GRAPHICS]
ER -
CAPOOR, Manu, Jan LOCHMAN, Andrew MCDOWELL, Jonathan E. SCHMITZ, Martin SOLANSKÝ, Martina ZAPLETALOVÁ, Todd F. ALAMIN, Michael F. COSCIA, Steven R. GARFIN, Radim JANČÁLEK, Filip RŮŽIČKA, Nick A. SHAMIE, Martin SMRČKA, Jeffrey C. WANG, Christof BIRKENMAIER a Ondřej SLABÝ. Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections. \textit{European Spine Journal}. NEW YORK: Springer, roč.~28, č.~4, s.~783-791. ISSN~0940-6719. doi:10.1007/s00586-018-5838-z. 2019.
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