Intervertebral disc penetration by antibiotics used
prophylactically in spinal surgery: implications for the
current standards and treatment of disc infections

J 2019

Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections

CAPOOR, Manu, Jan LOCHMAN, Andrew MCDOWELL, Jonathan E. SCHMITZ, Martin SOLANSKÝ et. al.

Basic information

Original name

Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections

Authors

CAPOOR, Manu (840 United States of America, belonging to the institution), Jan LOCHMAN (203 Czech Republic, belonging to the institution), Andrew MCDOWELL (826 United Kingdom of Great Britain and Northern Ireland), Jonathan E. SCHMITZ (840 United States of America), Martin SOLANSKÝ (203 Czech Republic, belonging to the institution), Martina ZAPLETALOVÁ (203 Czech Republic, belonging to the institution), Todd F. ALAMIN (840 United States of America), Michael F. COSCIA (840 United States of America), Steven R. GARFIN (840 United States of America), Radim JANČÁLEK (203 Czech Republic, belonging to the institution), Filip RŮŽIČKA (203 Czech Republic, belonging to the institution), Nick A. SHAMIE (840 United States of America), Martin SMRČKA (203 Czech Republic, belonging to the institution), Jeffrey C. WANG (840 United States of America), Christof BIRKENMAIER (276 Germany) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution)

Edition

European Spine Journal, NEW YORK, Springer, 2019, 0940-6719

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.458

RIV identification code

RIV/00216224:14740/19:00109487

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1007/s00586-018-5838-z

UT WoS

000463673200018

Keywords in English

Propionibacterium acnes; Cutibacterium acnes; Degenerative disc disease; Biofilm; Cefazolin; Clindamycin; Vancomycin; Surgical prophylaxis

Abstract

V originále

PurposeThe presence of Propionibacterium acnes in a substantial component of resected disc specimens obtained from patients undergoing discectomy or microdiscectomy has led to the suggestion that this prominent human skin and oral commensal may exacerbate the pathology of degenerative disc disease. This hypothesis, therefore, raises the exciting possibility that antibiotics could play an important role in treating this debilitating condition. To date, however, little information about antibiotic penetration into the intervertebral disc is available. MethodsIntervertebral disc tissue obtained from 54 microdiscectomy patients given prophylactic cefazolin (n=25), clindamycin (n=17) or vancomycin (n=12) was assayed by high-performance liquid chromatography, with cefaclor as an internal standard, to determine the concentration of antibiotic penetrating into the disc tissue.ResultsIntervertebral disc tissues from patients receiving the positively charged antibiotic clindamycin contained a significantly greater percentage of the antibacterial dose than the tissue from patients receiving negatively charged cefazolin (P<0.0001) and vancomycin, which has a slight positive charge (P<0.0001).ConclusionPositively charged antibiotics appear more appropriate for future studies investigating potential options for the treatment of low-virulence disc infections. [GRAPHICS]

Links

MUNI/A/1189/2018, interní kód MU

Name: Původci nozokomiálních nákaz a možnosti jejich diagnostiky a terapie (Acronym: PNNMDT)

Investor: Masaryk University, Category A

Citovat

CAPOOR, Manu, Jan LOCHMAN, Andrew MCDOWELL, Jonathan E. SCHMITZ, Martin SOLANSKÝ, Martina ZAPLETALOVÁ, Todd F. ALAMIN, Michael F. COSCIA, Steven R. GARFIN, Radim JANČÁLEK, Filip RŮŽIČKA, Nick A. SHAMIE, Martin SMRČKA, Jeffrey C. WANG, Christof BIRKENMAIER and Ondřej SLABÝ. Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections. European Spine Journal. NEW YORK: Springer, 2019, vol. 28, No 4, p. 783-791. ISSN 0940-6719. Available from: https://dx.doi.org/10.1007/s00586-018-5838-z.

@article{1522757,
   author = {Capoor, Manu and Lochman, Jan and McDowell, Andrew and Schmitz, Jonathan E. and Solanský, Martin and Zapletalová, Martina and Alamin, Todd F. and Coscia, Michael F. and Garfin, Steven R. and Jančálek, Radim and Růžička, Filip and Shamie, Nick A. and Smrčka, Martin and Wang, Jeffrey C. and Birkenmaier, Christof and Slabý, Ondřej},
   article_location = {NEW YORK},
   article_number = {4},
   doi = {http://dx.doi.org/10.1007/s00586-018-5838-z},
   keywords = {Propionibacterium acnes; Cutibacterium acnes; Degenerative disc disease; Biofilm; Cefazolin; Clindamycin; Vancomycin; Surgical prophylaxis},
   language = {eng},
   issn = {0940-6719},
   journal = {European Spine Journal},
   title = {Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections},
   url = {https://link.springer.com/content/pdf/10.1007/s00586-018-5838-z.pdf},
   volume = {28},
   year = {2019}
}

TY  - JOUR
ID  - 1522757
AU  - Capoor, Manu - Lochman, Jan - McDowell, Andrew - Schmitz, Jonathan E. - Solanský, Martin - Zapletalová, Martina - Alamin, Todd F. - Coscia, Michael F. - Garfin, Steven R. - Jančálek, Radim - Růžička, Filip - Shamie, Nick A. - Smrčka, Martin - Wang, Jeffrey C. - Birkenmaier, Christof - Slabý, Ondřej
PY  - 2019
TI  - Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections
JF  - European Spine Journal
VL  - 28
IS  - 4
SP  - 783-791
EP  - 783-791
PB  - Springer
SN  - 09406719
KW  - Propionibacterium acnes
KW  - Cutibacterium acnes
KW  - Degenerative disc disease
KW  - Biofilm
KW  - Cefazolin
KW  - Clindamycin
KW  - Vancomycin
KW  - Surgical prophylaxis
UR  - https://link.springer.com/content/pdf/10.1007/s00586-018-5838-z.pdf
L2  - https://link.springer.com/content/pdf/10.1007/s00586-018-5838-z.pdf
N2  - PurposeThe presence of Propionibacterium acnes in a substantial component of resected disc specimens obtained from patients undergoing discectomy or microdiscectomy has led to the suggestion that this prominent human skin and oral commensal may exacerbate the pathology of degenerative disc disease. This hypothesis, therefore, raises the exciting possibility that antibiotics could play an important role in treating this debilitating condition. To date, however, little information about antibiotic penetration into the intervertebral disc is available. MethodsIntervertebral disc tissue obtained from 54 microdiscectomy patients given prophylactic cefazolin (n=25), clindamycin (n=17) or vancomycin (n=12) was assayed by high-performance liquid chromatography, with cefaclor as an internal standard, to determine the concentration of antibiotic penetrating into the disc tissue.ResultsIntervertebral disc tissues from patients receiving the positively charged antibiotic clindamycin contained a significantly greater percentage of the antibacterial dose than the tissue from patients receiving negatively charged cefazolin (P<0.0001) and vancomycin, which has a slight positive charge (P<0.0001).ConclusionPositively charged antibiotics appear more appropriate for future studies investigating potential options for the treatment of low-virulence disc infections. [GRAPHICS]
ER  -

CAPOOR, Manu, Jan LOCHMAN, Andrew MCDOWELL, Jonathan E. SCHMITZ, Martin SOLANSKÝ, Martina ZAPLETALOVÁ, Todd F. ALAMIN, Michael F. COSCIA, Steven R. GARFIN, Radim JANČÁLEK, Filip RŮŽIČKA, Nick A. SHAMIE, Martin SMRČKA, Jeffrey C. WANG, Christof BIRKENMAIER and Ondřej SLABÝ. Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections. \textit{European Spine Journal}. NEW YORK: Springer, 2019, vol.~28, No~4, p.~783-791. ISSN~0940-6719. Available from: https://dx.doi.org/10.1007/s00586-018-5838-z.

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