J 2019

Correlation of tumor necrosis factor alpha, interleukin 6 and interleukin 10 with blood pressure, risk of preeclampsia and low birth weight in gestational diabetes

ŽÁK, Petr and Miroslav SOUČEK

Basic information

Original name

Correlation of tumor necrosis factor alpha, interleukin 6 and interleukin 10 with blood pressure, risk of preeclampsia and low birth weight in gestational diabetes

Name in Czech

Korelace tumor necrosis factor alpha, interleukinu-6, interleukinu-10 s krevním tlakem, rizikem preeklampsie a nizkou porodní hmotností

Authors

ŽÁK, Petr (203 Czech Republic, guarantor, belonging to the institution) and Miroslav SOUČEK (203 Czech Republic, belonging to the institution)

Edition

Physiological Research, Prague, AV ČR, Institute of Physiology, 2019, 0862-8408

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 1.655

RIV identification code

RIV/00216224:14110/19:00109499

Organization unit

Faculty of Medicine

DOI

UT WoS

000476830200006

Keywords (in Czech)

cytokin IL-6; Il-10; TNF alpha

Keywords in English

cytokine IL-6; Il-10; TNF alpha

Tags

Tags

International impact, Reviewed
Změněno: 14/4/2020 14:20, Mgr. Tereza Miškechová

Abstract

V originále

Several pathophysiological mechanisms have been proposed in the development of pregnancy complications, including endothelial dysfunction, an inflammatory pathway and oxidative stress. The aim of the present study was to evaluate the correlation between proinflammatory cytokines TNF-alpha, IL-6 and dual cytokine IL-10 in the mother's peripheral blood and systolic blood pressure, risk of preeclampsia and low birth weight in gestational diabetes (GDM). We observed 40 women with GDM divided into a gestational hypertension group (n=20) and comparison group (n=20) with normal blood pressure. We found a significant positive correlation between TNF-alpha; IL-6; IL-10 levels and systolic blood pressure (SBP) in the second trimester (p<0.001; p<0.001; p<0.001); the third trimester (p<0.001; p<0.001; p<0.05). We also proved correlations for diastolic blood pressure (DBP) during the second; third trimester (p<0.001; p<0.001; p<0.001); (p<0.001; p<0.001; p<0.0015). We demonstrated a statistically significant positive association between high TNF-alpha group and preeclampsia risk in the third trimester (p=0.04). We also determined the negative correlation in the second trimester between birth weight and TNF-alpha; IL-6, IL-10 levels (p<0.05; p<0.001; p<0.001). To conclude, our data highlight the importance of cytokines TNF-alpha, IL-6 and IL-10 in blood pressure regulation. In addition, high levels of TNF-alpha have been associated with increased risk of preeclampsia. We found a significant negative correlation between levels of TNF-alpha, IL-6, IL-10 and birth weight.