Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review

PELTANOVÁ, Barbora, Martina RAUDENSKÁ and Michal MASAŘÍK. Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review. Molecular Cancer. LONDON: BioMed Central Ltd, 2019, vol. 18, No 63, p. 1-24. ISSN 1476-4598. Available from: https://dx.doi.org/10.1186/s12943-019-0983-5.

Basic information

• Original name: Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review
• Authors: PELTANOVÁ, Barbora (203 Czech Republic, belonging to the institution), Martina RAUDENSKÁ (203 Czech Republic, belonging to the institution) and Michal MASAŘÍK (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Molecular Cancer, LONDON, BioMed Central Ltd, 2019, 1476-4598.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10601 Cell biology
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 15.302
• RIV identification code: RIV/00216224:14110/19:00107373
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1186/s12943-019-0983-5
• UT WoS: 000462941900021
• Keywords in English: Tumor microenvironment; Head and neck cancer; Tumor metabolism; Epithelial-mesenchymal transition
• Tags: 14110515, 14110518, rivok
• Tags: International impact, Reviewed

Abstract

The tumor microenvironment (TME) is comprised of many different cell populations, such as cancer-associated fibroblasts and various infiltrating immune cells, and non-cell components of extracellular matrix. These crucial parts of the surrounding stroma can function as both positive and negative regulators of all hallmarks of cancer development, including evasion of apoptosis, induction of angiogenesis, deregulation of the energy metabolism, resistance to the immune detection and destruction, and activation of invasion and metastasis. This review represents a summary of recent studies focusing on describing these effects of microenvironment on initiation and progression of the head and neck squamous cell carcinoma, focusing on oral squamous cell carcinoma, since it is becoming clear that an investigation of differences in stromal composition of the head and neck squamous cell carcinoma microenvironment and their impact on cancer development and progression may help better understand the mechanisms behind different responses to therapy and help define possible targets for clinical intervention.

Links

• GA18-03978S, research and development project: Name: Efekt buněčné tuhosti a mikroprostředí jako prediktor odpovědi na léčbu karcinomů hlavy a krku

Investor: Czech Science Foundation

• MUNI/A/1297/2017, interní kód MU: Name: Tkáňové aspekty patofyziologických stavů (Acronym: patologická tkáň)

Investor: Masaryk University, Category A

• MUNI/A/1553/2018, interní kód MU: Name: Genetické, environmentální a tkáňové charakteristiky vybraných patologických stavů a nemocí (Acronym: genetika; stres; biomateriály; tkáňové kultury)

Investor: Masaryk University, Category A

• NV18-08-00229, research and development project: Name: Interakce buněk nádorového mikroprostředí jako nový nástroj predikce účinnosti terapie nádorů hlavy a krku

Investor: Ministry of Health of the CR