J 2019

Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review

PELTANOVÁ, Barbora, Martina RAUDENSKÁ and Michal MASAŘÍK

Basic information

Original name

Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review

Authors

PELTANOVÁ, Barbora (203 Czech Republic, belonging to the institution), Martina RAUDENSKÁ (203 Czech Republic, belonging to the institution) and Michal MASAŘÍK (203 Czech Republic, guarantor, belonging to the institution)

Edition

Molecular Cancer, LONDON, BioMed Central Ltd, 2019, 1476-4598

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10601 Cell biology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 15.302

RIV identification code

RIV/00216224:14110/19:00107373

Organization unit

Faculty of Medicine

DOI

UT WoS

000462941900021

Keywords in English

Tumor microenvironment; Head and neck cancer; Tumor metabolism; Epithelial-mesenchymal transition

Tags

Tags

International impact, Reviewed
Změněno: 4/3/2020 15:35, Mgr. Tereza Miškechová

Abstract

V originále

The tumor microenvironment (TME) is comprised of many different cell populations, such as cancer-associated fibroblasts and various infiltrating immune cells, and non-cell components of extracellular matrix. These crucial parts of the surrounding stroma can function as both positive and negative regulators of all hallmarks of cancer development, including evasion of apoptosis, induction of angiogenesis, deregulation of the energy metabolism, resistance to the immune detection and destruction, and activation of invasion and metastasis. This review represents a summary of recent studies focusing on describing these effects of microenvironment on initiation and progression of the head and neck squamous cell carcinoma, focusing on oral squamous cell carcinoma, since it is becoming clear that an investigation of differences in stromal composition of the head and neck squamous cell carcinoma microenvironment and their impact on cancer development and progression may help better understand the mechanisms behind different responses to therapy and help define possible targets for clinical intervention.

Links

GA18-03978S, research and development project
Name: Efekt buněčné tuhosti a mikroprostředí jako prediktor odpovědi na léčbu karcinomů hlavy a krku
Investor: Czech Science Foundation
MUNI/A/1297/2017, interní kód MU
Name: Tkáňové aspekty patofyziologických stavů (Acronym: patologická tkáň)
Investor: Masaryk University, Category A
MUNI/A/1553/2018, interní kód MU
Name: Genetické, environmentální a tkáňové charakteristiky vybraných patologických stavů a nemocí (Acronym: genetika; stres; biomateriály; tkáňové kultury)
Investor: Masaryk University, Category A
NV18-08-00229, research and development project
Name: Interakce buněk nádorového mikroprostředí jako nový nástroj predikce účinnosti terapie nádorů hlavy a krku
Investor: Ministry of Health of the CR