J 2018

HSPB7 GENE POLYMORPHISM ASSOCIATED WITH ANTHROPOMETRIC PARAMETERS OF OBESITY AND FAT INTAKE IN A CENTRAL EUROPEAN POPULATION

PAVLOVÁ, Tereza, Jan NOVÁK, Filip ZLÁMAL and Julie DOBROVOLNÁ

Basic information

Original name

HSPB7 GENE POLYMORPHISM ASSOCIATED WITH ANTHROPOMETRIC PARAMETERS OF OBESITY AND FAT INTAKE IN A CENTRAL EUROPEAN POPULATION

Authors

PAVLOVÁ, Tereza (203 Czech Republic, guarantor, belonging to the institution), Jan NOVÁK (203 Czech Republic, belonging to the institution), Filip ZLÁMAL (203 Czech Republic, belonging to the institution) and Julie DOBROVOLNÁ (203 Czech Republic, belonging to the institution)

Edition

Central European journal of public health, Praha, Česká lékařská společnost J.E. Purkyně, 2018, 1210-7778

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 0.636

RIV identification code

RIV/00216224:14310/18:00106852

Organization unit

Faculty of Science

DOI

UT WoS

000463167100005

Keywords in English

HSPB7; obesity; polymorphism; dietary composition; fat intake; rs1048261

Tags

Tags

International impact, Reviewed
Změněno: 23/4/2024 14:47, Mgr. Michal Petr

Abstract

V originále

Objective: Heat shock proteins act as chaperones at the molecular level and therefore they have been investigated in numerous diseases associated with oxidative stress, including obesity. The aim of this study was to investigate the possible associations of genetic variability in the 3'-untranslated region of the HSPB7 gene (rs1048261) with anthropometric and dietary parameters in a cohort of lean and obese Central European subjects. Methods: A total of 708 Central European Caucasian individuals were enrolled in this study, 415 obese subjects and 293 non-obese subjects. The rs1048261 genotypes were established using a conventional PCR-based methodology. Results: Significant differences were observed in the total daily fat intake between subjects with AT and TT genotypes (82.6 +/- 29.2 g vs. 74.1 +/- 31.3 g, p = 0.023) and also borderline significance in daily proportion of fat in the diet between AA and TT genotypes (36.0 +/- 4.4% vs. 33.3 +/- 5.9%, p = 0.061). Based on the linear regression model we found association between rs1048261 genotype and body fat percentage. Conclusions: To the best of our knowledge, this is the first study which reports an association of defined genetic variability in the HSPB7 gene, rs1048261, with obesity and its associated anthropometric characteristics and dietary composition.

Links

EF15_003/0000469, research and development project
Name: Cetocoen Plus
LM2015051, research and development project
Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)
Investor: Ministry of Education, Youth and Sports of the CR