Detailed Information on Publication Record
2019
Common variable immunodeficiency patients display elevated plasma levels of granulocyte activation markers elastase and myeloperoxidase
LITZMAN, Jiří, Zita CHOVANCOVÁ, Petr BEJDÁK, Marek LITZMAN, Zdeněk HEL et. al.Basic information
Original name
Common variable immunodeficiency patients display elevated plasma levels of granulocyte activation markers elastase and myeloperoxidase
Authors
LITZMAN, Jiří (203 Czech Republic, belonging to the institution), Zita CHOVANCOVÁ (203 Czech Republic, belonging to the institution), Petr BEJDÁK (203 Czech Republic, belonging to the institution), Marek LITZMAN (203 Czech Republic), Zdeněk HEL (840 United States of America) and Marcela VLKOVÁ (203 Czech Republic, guarantor, belonging to the institution)
Edition
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, THOUSAND OAKS, SAGE PUBLICATIONS INC, 2019, 0394-6320
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30102 Immunology
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 2.209
RIV identification code
RIV/00216224:14110/19:00108463
Organization unit
Faculty of Medicine
UT WoS
000464236600001
Keywords in English
CVID; elastase; immunoglobulin treatment; myeloperoxidase; neutrophil activation
Tags
International impact, Reviewed
Změněno: 11/5/2020 09:15, Mgr. Tereza Miškechová
Abstract
V originále
Common variable immunodeficiency disorders (CVIDs) represent a group of primary immunodeficiency diseases characterized by hypogammaglobulinemia and dysfunctional immune response to invading pathogens. Previous studies have indicated that CVID is associated with microbial translocation and systemic myeloid cell activation. The goal of this study was to determine whether patients with CVID display elevated systemic levels of markers of granulocyte activation and whether the levels are further influenced by intravenous immunoglobulin (IVIg) infusions. The plasma levels of granulocyte activation markers elastase and myeloperoxidase were determined using enzyme-linked immunosorbent assay (ELISA) in 46 CVID patients and 44 healthy controls. All CVID patients were in a stable state with no apparent acute infection. In addition, granulocyte activation markers' plasma levels in 24 CVID patients were determined prior to and 1 h following IVIg administration. Neutrophil elastase and myeloperoxidase plasma levels were significantly higher in CVID patients than in healthy controls. Systemic elastase levels were further increased following IVIg administration. In vitro stimulation of 13 CVID patients' whole blood using IVIg in a therapeutically relevant dose for 2 h resulted in a significant increase in plasma elastase levels compared to unstimulated blood. The data presented here indicate that CVID is associated with chronic granulocytic activation which is further exacerbated by administering IVIg. Increased myeloperoxidase and elastase levels may contribute to associated comorbidities in CVID patients.
Links
| NV15-28732A, research and development project |
|