| OPPEDAL, Ketil, Daniel FERREIRA, Lena CAVALLIN, Afina W. LEMSTRA, Mara TEN KATE, Alessandro PADOVANI, Irena REKTOROVÁ, Laura BONANNI, Lars-Olof WAHLUND, Knut ENGEDAL, Flavio NOBILI, Milica KRAMBERGER, John-Paul TAYLOR, Jakub HORT, Jon SNAEDAL, Frederic BLANC, Zuzana WALKER, Angelo ANTONINI, Eric WESTMAN and Dag AARSLAND. A signature pattern of cortical atrophy in dementia with Lewy bodies: A study on 333 patients from the European DLB consortium. ALZHEIMERS & DEMENTIA. NEW YORK: ELSEVIER SCIENCE INC, 2019, vol. 15, No 3, p. 400-409. ISSN 1552-5260. Available from: https://dx.doi.org/10.1016/j.jalz.2018.09.011. |
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@article{1527098,
author = {Oppedal, Ketil and Ferreira, Daniel and Cavallin, Lena and Lemstra, Afina W. and ten Kate, Mara and Padovani, Alessandro and Rektorová, Irena and Bonanni, Laura and Wahlund, LarsandOlof and Engedal, Knut and Nobili, Flavio and Kramberger, Milica and Taylor, JohnandPaul and Hort, Jakub and Snaedal, Jon and Blanc, Frederic and Walker, Zuzana and Antonini, Angelo and Westman, Eric and Aarsland, Dag},
article_location = {NEW YORK},
article_number = {3},
doi = {http://dx.doi.org/10.1016/j.jalz.2018.09.011},
keywords = {Dementia; Alzheimer's disease; Dementia with Lewy bodies},
language = {eng},
issn = {1552-5260},
journal = {ALZHEIMERS & DEMENTIA},
title = {A signature pattern of cortical atrophy in dementia with Lewy bodies: A study on 333 patients from the European DLB consortium},
url = {https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1016/j.jalz.2018.09.011},
volume = {15},
year = {2019}
}
TY - JOUR
ID - 1527098
AU - Oppedal, Ketil - Ferreira, Daniel - Cavallin, Lena - Lemstra, Afina W. - ten Kate, Mara - Padovani, Alessandro - Rektorová, Irena - Bonanni, Laura - Wahlund, Lars-Olof - Engedal, Knut - Nobili, Flavio - Kramberger, Milica - Taylor, John-Paul - Hort, Jakub - Snaedal, Jon - Blanc, Frederic - Walker, Zuzana - Antonini, Angelo - Westman, Eric - Aarsland, Dag
PY - 2019
TI - A signature pattern of cortical atrophy in dementia with Lewy bodies: A study on 333 patients from the European DLB consortium
JF - ALZHEIMERS & DEMENTIA
VL - 15
IS - 3
SP - 400-409
EP - 400-409
PB - ELSEVIER SCIENCE INC
SN - 15525260
KW - Dementia
KW - Alzheimer's disease
KW - Dementia with Lewy bodies
UR - https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1016/j.jalz.2018.09.011
L2 - https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1016/j.jalz.2018.09.011
N2 - Introduction: We explored regional brain atrophy patterns and their clinical correlates in dementia with Lewy bodies (DLB). Methods: In this multicentre study, we included a total of 333 patients with DLB, 352 patients with Alzheimer's disease (AD), and 233 normal controls and used medial temporal lobe atrophy, posterior atrophy, and frontal atrophy (GCA-F) visual rating scales. Patients were classified according to four atrophy patterns. Results: Patients with DLB had higher scores on all the three atrophy scales than normal controls but had less medial temporal lobe atrophy than those with AD (all P values < 001). A signature hippocampal-sparing pattern of regional atrophy was observed in DLB. The magnetic resonance imaging measures showed 65% ability to discriminate between DLB and AD and marginally contributed to the discrimination over and above the core clinical features. Discussion: The most common pattern of atrophy of DLB was hippocampal-sparing. Future studies should explore whether comorbid AD pathology underlies the atrophy patterns seen in DLB. (C) 2018 Published by Elsevier Inc. on behalf of the Alzheimer's Association.
ER -
OPPEDAL, Ketil, Daniel FERREIRA, Lena CAVALLIN, Afina W. LEMSTRA, Mara TEN KATE, Alessandro PADOVANI, Irena REKTOROVÁ, Laura BONANNI, Lars-Olof WAHLUND, Knut ENGEDAL, Flavio NOBILI, Milica KRAMBERGER, John-Paul TAYLOR, Jakub HORT, Jon SNAEDAL, Frederic BLANC, Zuzana WALKER, Angelo ANTONINI, Eric WESTMAN and Dag AARSLAND. A signature pattern of cortical atrophy in dementia with Lewy bodies: A study on 333 patients from the European DLB consortium. \textit{ALZHEIMERS \&{}amp; DEMENTIA}. NEW YORK: ELSEVIER SCIENCE INC, 2019, vol.~15, No~3, p.~400-409. ISSN~1552-5260. Available from: https://dx.doi.org/10.1016/j.jalz.2018.09.011.
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