Perampanel as monotherapy and adjunctive therapy for focal
onset seizures, focal to bilateral tonic-clonic seizures and as
adjunctive therapy of generalized onset tonic-clonic seizures

J 2019

Perampanel as monotherapy and adjunctive therapy for focal onset seizures, focal to bilateral tonic-clonic seizures and as adjunctive therapy of generalized onset tonic-clonic seizures

TYRLÍKOVÁ, Ivana, Milan BRÁZDIL, Ivan REKTOR and Michal TYRLÍK

Basic information

Original name

Perampanel as monotherapy and adjunctive therapy for focal onset seizures, focal to bilateral tonic-clonic seizures and as adjunctive therapy of generalized onset tonic-clonic seizures

Authors

TYRLÍKOVÁ, Ivana (203 Czech Republic, guarantor, belonging to the institution), Milan BRÁZDIL (203 Czech Republic, belonging to the institution), Ivan REKTOR (203 Czech Republic, belonging to the institution) and Michal TYRLÍK (840 United States of America)

Edition

Expert Review of Neurotherapeutics, London, Expert Reviews, 2019, 1473-7175

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.743

RIV identification code

RIV/00216224:14110/19:00109550

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1080/14737175.2019.1555474

UT WoS

000456591500001

Keywords in English

AMPA receptor antagonist; anti-seizure drug; adjunctive therapy; monotherapy; focal seizures; generalized tonic-clonic seizures

Abstract

V originále

Introduction: Perampanel is an antiepileptic drug approved in the USA and Europe as monotherapy and adjunctive therapy for focal onset seizures and as adjunctive therapy for generalized tonic-clonic seizures. Areas covered: This an overview of animal data, pharmacokinetics, and clinical data published on Perampanel indexed in PubMed. Expert opinion: Pharmacological studies suggest that perampanel acts via noncompetitive antagonism of the ionotropic AMPA receptor of glutamate. The efficacy of perampanel has been shown in animal models of epilepsy and Phase II/III clinical trials. Efficacy and safety have been evaluated in the phase III trials of adjunctive treatment of focal epilepsy with median focal onset seizure reduction rates of 23% for 4 mg/d, 26-31% for 8 mg/day, and 18-35% for 12 mg/day. Fifty percent responder rates were 29% for 4 mg/day, 33-38% for 8 mg/day, and 34-36% for 12 mg/day. A pivotal Phase III trial in generalized onset tonic-clonic seizures showed a median seizure reduction by 76.5% (8 mg) versus 38.4% placebo and 50% seizure responder rate of 64.2% versus 30.9% placebo. Perampanel showed good safety and tolerability profile across 2-12 mg doses. Perampanel as a broad-spectrum antiepileptic drug has a potential to be an alternative treatment of multiple types of epileptic seizures.

Citovat

TYRLÍKOVÁ, Ivana, Milan BRÁZDIL, Ivan REKTOR and Michal TYRLÍK. Perampanel as monotherapy and adjunctive therapy for focal onset seizures, focal to bilateral tonic-clonic seizures and as adjunctive therapy of generalized onset tonic-clonic seizures. Expert Review of Neurotherapeutics. London: Expert Reviews, 2019, vol. 19, No 1, p. 5-16. ISSN 1473-7175. Available from: https://dx.doi.org/10.1080/14737175.2019.1555474.

@article{1527176,
   author = {Tyrlíková, Ivana and Brázdil, Milan and Rektor, Ivan and Tyrlík, Michal},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1080/14737175.2019.1555474},
   keywords = {AMPA receptor antagonist; anti-seizure drug; adjunctive therapy; monotherapy; focal seizures; generalized tonic-clonic seizures},
   language = {eng},
   issn = {1473-7175},
   journal = {Expert Review of Neurotherapeutics},
   title = {Perampanel as monotherapy and adjunctive therapy for focal onset seizures, focal to bilateral tonic-clonic seizures and as adjunctive therapy of generalized onset tonic-clonic seizures},
   url = {http://dx.doi.org/10.1080/14737175.2019.1555474},
   volume = {19},
   year = {2019}
}

TY  - JOUR
ID  - 1527176
AU  - Tyrlíková, Ivana - Brázdil, Milan - Rektor, Ivan - Tyrlík, Michal
PY  - 2019
TI  - Perampanel as monotherapy and adjunctive therapy for focal onset seizures, focal to bilateral tonic-clonic seizures and as adjunctive therapy of generalized onset tonic-clonic seizures
JF  - Expert Review of Neurotherapeutics
VL  - 19
IS  - 1
SP  - 5-16
EP  - 5-16
PB  - Expert Reviews
SN  - 14737175
KW  - AMPA receptor antagonist
KW  - anti-seizure drug
KW  - adjunctive therapy
KW  - monotherapy
KW  - focal seizures
KW  - generalized tonic-clonic seizures
UR  - http://dx.doi.org/10.1080/14737175.2019.1555474
L2  - http://dx.doi.org/10.1080/14737175.2019.1555474
N2  - Introduction: Perampanel is an antiepileptic drug approved in the USA and Europe as monotherapy and adjunctive therapy for focal onset seizures and as adjunctive therapy for generalized tonic-clonic seizures. Areas covered: This an overview of animal data, pharmacokinetics, and clinical data published on Perampanel indexed in PubMed. Expert opinion: Pharmacological studies suggest that perampanel acts via noncompetitive antagonism of the ionotropic AMPA receptor of glutamate. The efficacy of perampanel has been shown in animal models of epilepsy and Phase II/III clinical trials. Efficacy and safety have been evaluated in the phase III trials of adjunctive treatment of focal epilepsy with median focal onset seizure reduction rates of 23% for 4 mg/d, 26-31% for 8 mg/day, and 18-35% for 12 mg/day. Fifty percent responder rates were 29% for 4 mg/day, 33-38% for 8 mg/day, and 34-36% for 12 mg/day. A pivotal Phase III trial in generalized onset tonic-clonic seizures showed a median seizure reduction by 76.5% (8 mg) versus 38.4% placebo and 50% seizure responder rate of 64.2% versus 30.9% placebo. Perampanel showed good safety and tolerability profile across 2-12 mg doses. Perampanel as a broad-spectrum antiepileptic drug has a potential to be an alternative treatment of multiple types of epileptic seizures.
ER  -

TYRLÍKOVÁ, Ivana, Milan BRÁZDIL, Ivan REKTOR and Michal TYRLÍK. Perampanel as monotherapy and adjunctive therapy for focal onset seizures, focal to bilateral tonic-clonic seizures and as adjunctive therapy of generalized onset tonic-clonic seizures. \textit{Expert Review of Neurotherapeutics}. London: Expert Reviews, 2019, vol.~19, No~1, p.~5-16. ISSN~1473-7175. Available from: https://dx.doi.org/10.1080/14737175.2019.1555474.

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