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@article{1528796, author = {Buchta, David and Füzik, Tibor and Hrebík, Dominik and Levdansky, Yevgen and Sukeník, Lukáš and Mukhamedova, Liya and Moravcová, Jana and Vácha, Robert and Plevka, Pavel}, article_location = {London}, article_number = {MAR}, doi = {http://dx.doi.org/10.1038/s41467-019-09132-x}, keywords = {MOLECULAR-DYNAMICS; CONFORMATIONAL-CHANGES; FORCE-FIELD; CELL ENTRY; POLIOVIRUS; VIRUS; RNA; MODEL; TRANSITIONS; RECOGNITION}, language = {eng}, issn = {2041-1723}, journal = {Nature Communications}, title = {Enterovirus particles expel capsid pentamers to enable genome release}, url = {https://www.nature.com/articles/s41467-019-09132-x.pdf}, volume = {10}, year = {2019} }
TY - JOUR ID - 1528796 AU - Buchta, David - Füzik, Tibor - Hrebík, Dominik - Levdansky, Yevgen - Sukeník, Lukáš - Mukhamedova, Liya - Moravcová, Jana - Vácha, Robert - Plevka, Pavel PY - 2019 TI - Enterovirus particles expel capsid pentamers to enable genome release JF - Nature Communications VL - 10 IS - MAR SP - 1-9 EP - 1-9 PB - Nature Publishing Group SN - 20411723 KW - MOLECULAR-DYNAMICS KW - CONFORMATIONAL-CHANGES KW - FORCE-FIELD KW - CELL ENTRY KW - POLIOVIRUS KW - VIRUS KW - RNA KW - MODEL KW - TRANSITIONS KW - RECOGNITION UR - https://www.nature.com/articles/s41467-019-09132-x.pdf L2 - https://www.nature.com/articles/s41467-019-09132-x.pdf N2 - Viruses from the genus Enterovirus are important human pathogens. Receptor binding or exposure to acidic pH in endosomes converts enterovirus particles to an activated state that is required for genome release. However, the mechanism of enterovirus uncoating is not well understood. Here, we use cryo-electron microscopy to visualize virions of human echovirus 18 in the process of genome release. We discover that the exit of the RNA from the particle of echovirus 18 results in a loss of one, two, or three adjacent capsid-protein pentamers. The opening in the capsid, which is more than 120 A in diameter, enables the release of the genome without the need to unwind its putative double-stranded RNA segments. We also detect capsids lacking pentamers during genome release from echovirus 30. Thus, our findings uncover a mechanism of enterovirus genome release that could become target for antiviral drugs. ER -
BUCHTA, David, Tibor FÜZIK, Dominik HREBÍK, Yevgen LEVDANSKY, Lukáš SUKENÍK, Liya MUKHAMEDOVA, Jana MORAVCOVÁ, Robert VÁCHA and Pavel PLEVKA. Enterovirus particles expel capsid pentamers to enable genome release. \textit{Nature Communications}. London: Nature Publishing Group, 2019, vol.~10, MAR, p.~1-9. ISSN~2041-1723. Available from: https://dx.doi.org/10.1038/s41467-019-09132-x.
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