Single-Centre Experience with Patients Selection for Mechanical
Thrombectomy Based on Automated Computed Tomography Perfusion
Analysis-A Comparison with Computed TomographyCT Perfusion
Thrombectomy Trials

J 2019

Single-Centre Experience with Patients Selection for Mechanical Thrombectomy Based on Automated Computed Tomography Perfusion Analysis-A Comparison with Computed TomographyCT Perfusion Thrombectomy Trials

VANÍČEK, Jiří; Petra CIMFLOVÁ; Martin BULIK; Jiří JARKOVSKÝ; Veronika PRELECOVÁ et. al.

Basic information

Original name

Single-Centre Experience with Patients Selection for Mechanical Thrombectomy Based on Automated Computed Tomography Perfusion Analysis-A Comparison with Computed TomographyCT Perfusion Thrombectomy Trials

Authors

VANÍČEK, Jiří (203 Czech Republic, belonging to the institution); Petra CIMFLOVÁ (203 Czech Republic, guarantor, belonging to the institution); Martin BULIK (203 Czech Republic, belonging to the institution); Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution); Veronika PRELECOVÁ (703 Slovakia, belonging to the institution); Viktor SZEDER (840 United States of America) and Ondřej VOLNÝ (203 Czech Republic, belonging to the institution)

Edition

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, AMSTERDAM, ELSEVIER SCIENCE BV, 2019, 1052-3057

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

30103 Neurosciences

Country of publisher

Netherlands

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Impact factor

Impact factor: 1.787

RIV identification code

RIV/00216224:14110/19:00109662

Organization unit

Faculty of Medicine

DOI

https://doi.org/10.1016/j.jstrokecerebrovasdis.2018.12.041

UT WoS

000462349000042

EID Scopus

2-s2.0-85059844077

Keywords in English

Mechanical thrombectomy; CT perfusion; RAPID; single-centre experience

Abstract

In the original language

Background: In randomized clinical trials, mechanical thrombectomy (MT) was proved to be a highly effective treatment of acute ischemic stroke which improved clinical outcomes. Some of the trials used automated computed tomography perfusion (CTP) analysis for selection of participants. We present a single-center experience with CTP selection and comparison with CTP trials. Methods: Data of consecutive MT patients (from January 2016 to December 2017) were retrospectively reviewed. All patients with multiphase CT angiography confirmed the presence of anterior circulation large vessel occlusion/s in the intracranial internal carotid artery and/or middle cerebral artery (M1 orM2) and with admission brain CTP analyzed by RAPID software were included into the analysis. Results: Sixty-two patients fulfilled the inclusion criteria (mean age was 70.1 +/- 13.6 years, females 48.5%). At baseline, National Institutes of Health Stroke Scale score was 16 (IQR = 13-20), Alberta Stroke Program Early CT Score (ASPECTS) was 8 (IQR = 7-9), CTP core volume was 20 mL (IQR = 2-36), and CTP penumbra volume was 145.5 mL (IQR = 107-184). Time from stroke onset to imaging was 1 hour 32 minutes, time from stroke onset to reperfusion was 3 hours 50minutes, and median time from CT to reperfusion was 1 hour 56 minutes. Modified thrombolysis in cerebral infarction 2b/3 was achieved in 42 patients (67.7%). Twenty-three patients (37%) had modified Rankin scale 0-2 at 90 days. Conclusions: Our analysis of CTP-selected patients for MT supports clinical applicability of automated CTP analysis into everyday clinical practice.

Cite

VANÍČEK, Jiří; Petra CIMFLOVÁ; Martin BULIK; Jiří JARKOVSKÝ; Veronika PRELECOVÁ; Viktor SZEDER and Ondřej VOLNÝ. Single-Centre Experience with Patients Selection for Mechanical Thrombectomy Based on Automated Computed Tomography Perfusion Analysis-A Comparison with Computed TomographyCT Perfusion Thrombectomy Trials. JOURNAL OF STROKE & CEREBROVASCULAR DISEASES. AMSTERDAM: ELSEVIER SCIENCE BV, 2019, vol. 28, No 4, p. 1085-1092. ISSN 1052-3057. Available from: https://doi.org/10.1016/j.jstrokecerebrovasdis.2018.12.041.

@article{1531316,
   author = {Vaníček, Jiří and Cimflová, Petra and Bulik, Martin and Jarkovský, Jiří and Prelecová, Veronika and Szeder, Viktor and Volný, Ondřej},
   article_location = {AMSTERDAM},
   article_number = {4},
   doi = {https://doi.org/10.1016/j.jstrokecerebrovasdis.2018.12.041},
   keywords = {Mechanical thrombectomy; CT perfusion; RAPID; single-centre experience},
   language = {eng},
   issn = {1052-3057},
   journal = {JOURNAL OF STROKE & CEREBROVASCULAR DISEASES},
   title = {Single-Centre Experience with Patients Selection for Mechanical Thrombectomy Based on Automated Computed Tomography Perfusion Analysis-A Comparison with Computed TomographyCT Perfusion Thrombectomy Trials},
   url = {http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.12.041},
   volume = {28},
   year = {2019}
}

TY  - JOUR
ID  - 1531316
AU  - Vaníček, Jiří - Cimflová, Petra - Bulik, Martin - Jarkovský, Jiří - Prelecová, Veronika - Szeder, Viktor - Volný, Ondřej
PY  - 2019
TI  - Single-Centre Experience with Patients Selection for Mechanical Thrombectomy Based on Automated Computed Tomography Perfusion Analysis-A Comparison with Computed TomographyCT Perfusion Thrombectomy Trials
JF  - JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
VL  - 28
IS  - 4
SP  - 1085-1092
EP  - 1085-1092
PB  - ELSEVIER SCIENCE BV
SN  - 10523057
KW  - Mechanical thrombectomy
KW  - CT perfusion
KW  - RAPID
KW  - single-centre experience
UR  - http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.12.041
L2  - http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.12.041
N2  - Background: In randomized clinical trials, mechanical thrombectomy (MT) was proved to be a highly effective treatment of acute ischemic stroke which improved clinical outcomes. Some of the trials used automated computed tomography perfusion (CTP) analysis for selection of participants. We present a single-center experience with CTP selection and comparison with CTP trials. Methods: Data of consecutive MT patients (from January 2016 to December 2017) were retrospectively reviewed. All patients with multiphase CT angiography confirmed the presence of anterior circulation large vessel occlusion/s in the intracranial internal carotid artery and/or middle cerebral artery (M1 orM2) and with admission brain CTP analyzed by RAPID software were included into the analysis. Results: Sixty-two patients fulfilled the inclusion criteria (mean age was 70.1 +/- 13.6 years, females 48.5%). At baseline, National Institutes of Health Stroke Scale score was 16 (IQR = 13-20), Alberta Stroke Program Early CT Score (ASPECTS) was 8 (IQR = 7-9), CTP core volume was 20 mL (IQR = 2-36), and CTP penumbra volume was 145.5 mL (IQR = 107-184). Time from stroke onset to imaging was 1 hour 32 minutes, time from stroke onset to reperfusion was 3 hours 50minutes, and median time from CT to reperfusion was 1 hour 56 minutes. Modified thrombolysis in cerebral infarction 2b/3 was achieved in 42 patients (67.7%). Twenty-three patients (37%) had modified Rankin scale 0-2 at 90 days. Conclusions: Our analysis of CTP-selected patients for MT supports clinical applicability of automated CTP analysis into everyday clinical practice.
ER  -

VANÍČEK, Jiří; Petra CIMFLOVÁ; Martin BULIK; Jiří JARKOVSKÝ; Veronika PRELECOVÁ; Viktor SZEDER and Ondřej VOLNÝ. Single-Centre Experience with Patients Selection for Mechanical Thrombectomy Based on Automated Computed Tomography Perfusion Analysis-A Comparison with Computed TomographyCT Perfusion Thrombectomy Trials. \textit{JOURNAL OF STROKE \&{}amp; CEREBROVASCULAR DISEASES}. AMSTERDAM: ELSEVIER SCIENCE BV, 2019, vol.~28, No~4, p.~1085-1092. ISSN~1052-3057. Available from: https://doi.org/10.1016/j.jstrokecerebrovasdis.2018.12.041.

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