Single-Centre Experience with Patients Selection for Mechanical
Thrombectomy Based on Automated Computed Tomography Perfusion
Analysis-A Comparison with Computed TomographyCT Perfusion
Thrombectomy Trials

J 2019

Single-Centre Experience with Patients Selection for Mechanical Thrombectomy Based on Automated Computed Tomography Perfusion Analysis-A Comparison with Computed TomographyCT Perfusion Thrombectomy Trials

VANÍČEK, Jiří, Petra CIMFLOVÁ, Martin BULIK, Jiří JARKOVSKÝ, Veronika PRELECOVÁ et. al.

Basic information

Original name

Single-Centre Experience with Patients Selection for Mechanical Thrombectomy Based on Automated Computed Tomography Perfusion Analysis-A Comparison with Computed TomographyCT Perfusion Thrombectomy Trials

Authors

VANÍČEK, Jiří (203 Czech Republic, belonging to the institution), Petra CIMFLOVÁ (203 Czech Republic, guarantor, belonging to the institution), Martin BULIK (203 Czech Republic, belonging to the institution), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Veronika PRELECOVÁ (703 Slovakia, belonging to the institution), Viktor SZEDER (840 United States of America) and Ondřej VOLNÝ (203 Czech Republic, belonging to the institution)

Edition

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, AMSTERDAM, ELSEVIER SCIENCE BV, 2019, 1052-3057

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.787

RIV identification code

RIV/00216224:14110/19:00109662

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.12.041

UT WoS

000462349000042

Keywords in English

Mechanical thrombectomy; CT perfusion; RAPID; single-centre experience

Abstract

V originále

Background: In randomized clinical trials, mechanical thrombectomy (MT) was proved to be a highly effective treatment of acute ischemic stroke which improved clinical outcomes. Some of the trials used automated computed tomography perfusion (CTP) analysis for selection of participants. We present a single-center experience with CTP selection and comparison with CTP trials. Methods: Data of consecutive MT patients (from January 2016 to December 2017) were retrospectively reviewed. All patients with multiphase CT angiography confirmed the presence of anterior circulation large vessel occlusion/s in the intracranial internal carotid artery and/or middle cerebral artery (M1 orM2) and with admission brain CTP analyzed by RAPID software were included into the analysis. Results: Sixty-two patients fulfilled the inclusion criteria (mean age was 70.1 +/- 13.6 years, females 48.5%). At baseline, National Institutes of Health Stroke Scale score was 16 (IQR = 13-20), Alberta Stroke Program Early CT Score (ASPECTS) was 8 (IQR = 7-9), CTP core volume was 20 mL (IQR = 2-36), and CTP penumbra volume was 145.5 mL (IQR = 107-184). Time from stroke onset to imaging was 1 hour 32 minutes, time from stroke onset to reperfusion was 3 hours 50minutes, and median time from CT to reperfusion was 1 hour 56 minutes. Modified thrombolysis in cerebral infarction 2b/3 was achieved in 42 patients (67.7%). Twenty-three patients (37%) had modified Rankin scale 0-2 at 90 days. Conclusions: Our analysis of CTP-selected patients for MT supports clinical applicability of automated CTP analysis into everyday clinical practice.

Citovat

VANÍČEK, Jiří, Petra CIMFLOVÁ, Martin BULIK, Jiří JARKOVSKÝ, Veronika PRELECOVÁ, Viktor SZEDER and Ondřej VOLNÝ. Single-Centre Experience with Patients Selection for Mechanical Thrombectomy Based on Automated Computed Tomography Perfusion Analysis-A Comparison with Computed TomographyCT Perfusion Thrombectomy Trials. JOURNAL OF STROKE & CEREBROVASCULAR DISEASES. AMSTERDAM: ELSEVIER SCIENCE BV, 2019, vol. 28, No 4, p. 1085-1092. ISSN 1052-3057. Available from: https://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.12.041.

@article{1531316,
   author = {Vaníček, Jiří and Cimflová, Petra and Bulik, Martin and Jarkovský, Jiří and Prelecová, Veronika and Szeder, Viktor and Volný, Ondřej},
   article_location = {AMSTERDAM},
   article_number = {4},
   doi = {http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.12.041},
   keywords = {Mechanical thrombectomy; CT perfusion; RAPID; single-centre experience},
   language = {eng},
   issn = {1052-3057},
   journal = {JOURNAL OF STROKE & CEREBROVASCULAR DISEASES},
   title = {Single-Centre Experience with Patients Selection for Mechanical Thrombectomy Based on Automated Computed Tomography Perfusion Analysis-A Comparison with Computed TomographyCT Perfusion Thrombectomy Trials},
   url = {http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.12.041},
   volume = {28},
   year = {2019}
}

TY  - JOUR
ID  - 1531316
AU  - Vaníček, Jiří - Cimflová, Petra - Bulik, Martin - Jarkovský, Jiří - Prelecová, Veronika - Szeder, Viktor - Volný, Ondřej
PY  - 2019
TI  - Single-Centre Experience with Patients Selection for Mechanical Thrombectomy Based on Automated Computed Tomography Perfusion Analysis-A Comparison with Computed TomographyCT Perfusion Thrombectomy Trials
JF  - JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
VL  - 28
IS  - 4
SP  - 1085-1092
EP  - 1085-1092
PB  - ELSEVIER SCIENCE BV
SN  - 10523057
KW  - Mechanical thrombectomy
KW  - CT perfusion
KW  - RAPID
KW  - single-centre experience
UR  - http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.12.041
L2  - http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.12.041
N2  - Background: In randomized clinical trials, mechanical thrombectomy (MT) was proved to be a highly effective treatment of acute ischemic stroke which improved clinical outcomes. Some of the trials used automated computed tomography perfusion (CTP) analysis for selection of participants. We present a single-center experience with CTP selection and comparison with CTP trials. Methods: Data of consecutive MT patients (from January 2016 to December 2017) were retrospectively reviewed. All patients with multiphase CT angiography confirmed the presence of anterior circulation large vessel occlusion/s in the intracranial internal carotid artery and/or middle cerebral artery (M1 orM2) and with admission brain CTP analyzed by RAPID software were included into the analysis. Results: Sixty-two patients fulfilled the inclusion criteria (mean age was 70.1 +/- 13.6 years, females 48.5%). At baseline, National Institutes of Health Stroke Scale score was 16 (IQR = 13-20), Alberta Stroke Program Early CT Score (ASPECTS) was 8 (IQR = 7-9), CTP core volume was 20 mL (IQR = 2-36), and CTP penumbra volume was 145.5 mL (IQR = 107-184). Time from stroke onset to imaging was 1 hour 32 minutes, time from stroke onset to reperfusion was 3 hours 50minutes, and median time from CT to reperfusion was 1 hour 56 minutes. Modified thrombolysis in cerebral infarction 2b/3 was achieved in 42 patients (67.7%). Twenty-three patients (37%) had modified Rankin scale 0-2 at 90 days. Conclusions: Our analysis of CTP-selected patients for MT supports clinical applicability of automated CTP analysis into everyday clinical practice.
ER  -

VANÍČEK, Jiří, Petra CIMFLOVÁ, Martin BULIK, Jiří JARKOVSKÝ, Veronika PRELECOVÁ, Viktor SZEDER and Ondřej VOLNÝ. Single-Centre Experience with Patients Selection for Mechanical Thrombectomy Based on Automated Computed Tomography Perfusion Analysis-A Comparison with Computed TomographyCT Perfusion Thrombectomy Trials. \textit{JOURNAL OF STROKE \&{}amp; CEREBROVASCULAR DISEASES}. AMSTERDAM: ELSEVIER SCIENCE BV, 2019, vol.~28, No~4, p.~1085-1092. ISSN~1052-3057. Available from: https://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.12.041.

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