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@article{1531402, author = {Plutinský, Marek and Brat, Kristián and Svoboda, Michal and Zatloukal, Jaromir and Popelkova, Patricie and Koblizek, Vladimir}, article_location = {NEW YORK}, article_number = {2}, doi = {http://dx.doi.org/10.1007/s00408-019-00196-6}, keywords = {COPD; GOLD classification; Prognosis; Mortality}, language = {eng}, issn = {0341-2040}, journal = {LUNG}, title = {Prognostic Accuracy of Three COPD Classification Systems in Relation to Long-Term Mortality of COPD Patients: A Prospective Multicenter Study}, url = {http://dx.doi.org/10.1007/s00408-019-00196-6}, volume = {197}, year = {2019} }
TY - JOUR ID - 1531402 AU - Plutinský, Marek - Brat, Kristián - Svoboda, Michal - Zatloukal, Jaromir - Popelkova, Patricie - Koblizek, Vladimir PY - 2019 TI - Prognostic Accuracy of Three COPD Classification Systems in Relation to Long-Term Mortality of COPD Patients: A Prospective Multicenter Study JF - LUNG VL - 197 IS - 2 SP - 173-179 EP - 173-179 PB - SPRINGER SN - 03412040 KW - COPD KW - GOLD classification KW - Prognosis KW - Mortality UR - http://dx.doi.org/10.1007/s00408-019-00196-6 L2 - http://dx.doi.org/10.1007/s00408-019-00196-6 N2 - Recent research showed group B patients express higher mortality compared to group C patients when GOLD A-D grouping is used. We aimed to compare the prognostic accuracy of three GOLD classification systems, I-IV (pre-2011), A-D (2011-2016) and A-D (2017-present) in relation to mortality, exacerbation risk, quality of life (QoL) assessment and specific treatments use in a real-life COPD cohort. We used the data of 720 patients from the Czech Multicenter Research Database of COPD. Four-year mortality and time-to-exacerbation using the GOLD pre-2011, 2011-2016 and 2017-present classification schemes were assessed. Moreover, distribution of specific treatments use and QoL measures were analyzed. The GOLD I-IV classification system showed gradual increase in 4-year mortality across the stages (GOLD II 18.8%, III 28.5%, IV 38.7%) (p=0.001). Using the A-D 2011-2016 classification scheme, group C patients had lower mortality (16.7%) than group B (18.7%) (p=0.009). The A-D 2017-present classification showed higher mortality in group B (25.5%) compared to group C (20%) (p=0.05). For additional outcomes, the GOLD I-IV scheme showed highest match between the calculated 4-year exacerbation risk and QoL measures and GOLD stage/grouping. In terms of specific treatment distributions, various patterns for each GOLD classification system were observed with best match of GOLD 2017-present system to the layout of GOLD groups and categories. We conclude the GOLD I-IV classification system had the highest accuracy related to mortality, QoL measures and exacerbation risk prediction, while the A-D 2017-present scheme was most accurate within severity of symptoms prediction reflected also by more frequent specific treatments use. ER -
PLUTINSKÝ, Marek, Kristián BRAT, Michal SVOBODA, Jaromir ZATLOUKAL, Patricie POPELKOVA and Vladimir KOBLIZEK. Prognostic Accuracy of Three COPD Classification Systems in Relation to Long-Term Mortality of COPD Patients: A Prospective Multicenter Study. \textit{LUNG}. NEW YORK: SPRINGER, 2019, vol.~197, No~2, p.~173-179. ISSN~0341-2040. Available from: https://dx.doi.org/10.1007/s00408-019-00196-6.
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