Chronic Benign CD8+Proliferation: A Rare Affection that Can
Mimic a Lymphoma Relapse

J 2019

Chronic Benign CD8+Proliferation: A Rare Affection that Can Mimic a Lymphoma Relapse

OSOVSKA, Marcela, Andrea JANÍKOVÁ, Leoš KŘEN and Andrea MAREČKOVÁ

Basic information

Original name

Chronic Benign CD8+Proliferation: A Rare Affection that Can Mimic a Lymphoma Relapse

Authors

OSOVSKA, Marcela (203 Czech Republic), Andrea JANÍKOVÁ (203 Czech Republic, belonging to the institution), Leoš KŘEN (203 Czech Republic, belonging to the institution) and Andrea MAREČKOVÁ (203 Czech Republic, belonging to the institution)

Edition

CASE REPORTS IN HEMATOLOGY, LONDON, HINDAWI LTD, 2019, 2090-6560

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30205 Hematology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

RIV identification code

RIV/00216224:14110/19:00109676

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1155/2019/4932616

UT WoS

000461613800001

Keywords in English

Chronic benign CD8+ proliferation

Abstract

V originále

Chronic benign CD8+ proliferation is a rare syndrome that can take the form of a variety of other diseases. Peripheral adenopathy, cytopenia, and infiltration of the liver, kidneys, bowels, or other organs are the most common clinical presentations of the syndrome. CD8+ expansion can be clonal and nonclonal. It generally occurs in patients with innate or acquired immunodeficiency (HIV+) or in patients receiving immunosuppressive therapy. It has been found repeatedly in patients who developed severe hypogammaglobulinemia after treatment with rituximab. Diagnosis of the disease can be difficult because it can mimic relapse of a lymphoma, and a common biopsy examination cannot identify the problem at first. The authors describe a case of a patient pretreated with rituximab who developed agammaglobulinemia and peripheral adenopathy. Biopsy of an enlarged lymph node showed reactive lymphadenitis. Additionally, a flow-cytometric examination revealed a pathological population of CD8+ lymphocytes. The treatment, which differed from treatments of lymphoma relapse, consisted of corticosteroids and IVIG substitutions and has led to a regression of clinical symptoms. With more frequent usage of rituximab, one can expect increased occurrence of a very rare CD8+ expansion that can reliably emulate the relapse of a lymphoma.

Citovat

OSOVSKA, Marcela, Andrea JANÍKOVÁ, Leoš KŘEN and Andrea MAREČKOVÁ. Chronic Benign CD8+Proliferation: A Rare Affection that Can Mimic a Lymphoma Relapse. CASE REPORTS IN HEMATOLOGY. LONDON: HINDAWI LTD, 2019, vol. 2019, No 4932616, p. 1-4. ISSN 2090-6560. Available from: https://dx.doi.org/10.1155/2019/4932616.

@article{1531638,
   author = {Osovska, Marcela and Janíková, Andrea and Křen, Leoš and Marečková, Andrea},
   article_location = {LONDON},
   article_number = {4932616},
   doi = {http://dx.doi.org/10.1155/2019/4932616},
   keywords = {Chronic benign CD8+ proliferation},
   language = {eng},
   issn = {2090-6560},
   journal = {CASE REPORTS IN HEMATOLOGY},
   title = {Chronic Benign CD8+Proliferation: A Rare Affection that Can Mimic a Lymphoma Relapse},
   url = {http://dx.doi.org/10.1155/2019/4932616},
   volume = {2019},
   year = {2019}
}

TY  - JOUR
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AU  - Osovska, Marcela - Janíková, Andrea - Křen, Leoš - Marečková, Andrea
PY  - 2019
TI  - Chronic Benign CD8+Proliferation: A Rare Affection that Can Mimic a Lymphoma Relapse
JF  - CASE REPORTS IN HEMATOLOGY
VL  - 2019
IS  - 4932616
SP  - 1-4
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PB  - HINDAWI LTD
SN  - 20906560
KW  - Chronic benign CD8+ proliferation
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L2  - http://dx.doi.org/10.1155/2019/4932616
N2  - Chronic benign CD8+ proliferation is a rare syndrome that can take the form of a variety of other diseases. Peripheral adenopathy, cytopenia, and infiltration of the liver, kidneys, bowels, or other organs are the most common clinical presentations of the syndrome. CD8+ expansion can be clonal and nonclonal. It generally occurs in patients with innate or acquired immunodeficiency (HIV+) or in patients receiving immunosuppressive therapy. It has been found repeatedly in patients who developed severe hypogammaglobulinemia after treatment with rituximab. Diagnosis of the disease can be difficult because it can mimic relapse of a lymphoma, and a common biopsy examination cannot identify the problem at first. The authors describe a case of a patient pretreated with rituximab who developed agammaglobulinemia and peripheral adenopathy. Biopsy of an enlarged lymph node showed reactive lymphadenitis. Additionally, a flow-cytometric examination revealed a pathological population of CD8+ lymphocytes. The treatment, which differed from treatments of lymphoma relapse, consisted of corticosteroids and IVIG substitutions and has led to a regression of clinical symptoms. With more frequent usage of rituximab, one can expect increased occurrence of a very rare CD8+ expansion that can reliably emulate the relapse of a lymphoma.
ER  -

OSOVSKA, Marcela, Andrea JANÍKOVÁ, Leoš KŘEN and Andrea MAREČKOVÁ. Chronic Benign CD8+Proliferation: A Rare Affection that Can Mimic a Lymphoma Relapse. \textit{CASE REPORTS IN HEMATOLOGY}. LONDON: HINDAWI LTD, 2019, vol.~2019, No~4932616, p.~1-4. ISSN~2090-6560. Available from: https://dx.doi.org/10.1155/2019/4932616.

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