| XOCHELLI, A., Vasileios BIKOS, E. POLYCHRONIDOU, C. GALIGALIDOU, A. AGATHANGELIDIS, F. CHARLOTTE, P. MOSCHONAS, Z. DAVIS, M. COLOMBO, M. ROUMELIOTI, L.A. SUTTON, P. GROENEN, M. VAN DEN BRAND, M. BOUDJOGHRA, P. ALGARA, A. TRAVERSE-GLEHEN, A. FERRER, E. STALIKA, M. KARYPIDOU, G. KANELLIS, C. KALPADAKIS, M. MOLLEJO, G. PANGALIS, P. VLAMOS, R.M. AMINI, Šárka POSPÍŠILOVÁ, D. GONZALEZ, M. PONZONI, A. ANAGNOSTOPOULOS, V. GIUDICELLI, M.P. LEFRANC, B. ESPINET, P. PANAGIOTIDIS, M.A. PIRIS, M.Q. DU, R. ROSENQUIST, T. PAPADAKI, C. BELESSI, M. FERRARINI, D. OSCIER, D. TZOVARAS, P. GHIA, F. DAVI, A. HADZIDIMITRIOU a K. STAMATOPOULOS. Disease-biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations. JOURNAL OF PATHOLOGY. HOBOKEN: WILEY-BLACKWELL, 2019, roč. 247, č. 4, s. 416-421. ISSN 0022-3417. Dostupné z: https://dx.doi.org/10.1002/path.5209. |
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@article{1531662,
author = {Xochelli, A. and Bikos, Vasileios and Polychronidou, E. and Galigalidou, C. and Agathangelidis, A. and Charlotte, F. and Moschonas, P. and Davis, Z. and Colombo, M. and Roumelioti, M. and Sutton, L.A. and Groenen, P. and van den Brand, M. and Boudjoghra, M. and Algara, P. and TraverseandGlehen, A. and Ferrer, A. and Stalika, E. and Karypidou, M. and Kanellis, G. and Kalpadakis, C. and Mollejo, M. and Pangalis, G. and Vlamos, P. and Amini, R.M. and Pospíšilová, Šárka and Gonzalez, D. and Ponzoni, M. and Anagnostopoulos, A. and Giudicelli, V. and Lefranc, M.P. and Espinet, B. and Panagiotidis, P. and Piris, M.A. and Du, M.Q. and Rosenquist, R. and Papadaki, T. and Belessi, C. and Ferrarini, M. and Oscier, D. and Tzovaras, D. and Ghia, P. and Davi, F. and Hadzidimitriou, A. and Stamatopoulos, K.},
article_location = {HOBOKEN},
article_number = {4},
doi = {http://dx.doi.org/10.1002/path.5209},
keywords = {marginal zone lymphoma; ontogeny; immunoglobulin gene; antigen},
language = {eng},
issn = {0022-3417},
journal = {JOURNAL OF PATHOLOGY},
title = {Disease-biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations},
url = {https://onlinelibrary.wiley.com/doi/full/10.1002/path.5209},
volume = {247},
year = {2019}
}
TY - JOUR
ID - 1531662
AU - Xochelli, A. - Bikos, Vasileios - Polychronidou, E. - Galigalidou, C. - Agathangelidis, A. - Charlotte, F. - Moschonas, P. - Davis, Z. - Colombo, M. - Roumelioti, M. - Sutton, L.A. - Groenen, P. - van den Brand, M. - Boudjoghra, M. - Algara, P. - Traverse-Glehen, A. - Ferrer, A. - Stalika, E. - Karypidou, M. - Kanellis, G. - Kalpadakis, C. - Mollejo, M. - Pangalis, G. - Vlamos, P. - Amini, R.M. - Pospíšilová, Šárka - Gonzalez, D. - Ponzoni, M. - Anagnostopoulos, A. - Giudicelli, V. - Lefranc, M.P. - Espinet, B. - Panagiotidis, P. - Piris, M.A. - Du, M.Q. - Rosenquist, R. - Papadaki, T. - Belessi, C. - Ferrarini, M. - Oscier, D. - Tzovaras, D. - Ghia, P. - Davi, F. - Hadzidimitriou, A. - Stamatopoulos, K.
PY - 2019
TI - Disease-biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations
JF - JOURNAL OF PATHOLOGY
VL - 247
IS - 4
SP - 416-421
EP - 416-421
PB - WILEY-BLACKWELL
SN - 00223417
KW - marginal zone lymphoma
KW - ontogeny
KW - immunoglobulin gene
KW - antigen
UR - https://onlinelibrary.wiley.com/doi/full/10.1002/path.5209
L2 - https://onlinelibrary.wiley.com/doi/full/10.1002/path.5209
N2 - The B cell receptor immunoglobulin (Ig) gene repertoires of marginal zone (MZ) lymphoproliferations were analyzed in order to obtain insight into their ontogenetic relationships. Our cohort included cases with MZ lymphomas (n = 488), i.e. splenic (SMZL), nodal (NMZL) and extranodal (ENMZL), as well as provisional entities (n = 76), according to the WHO classification. The most striking Ig gene repertoire skewing was observed in SMZL. However, restrictions were also identified in all other MZ lymphomas studied, particularly ENMZL, with significantly different Ig gene distributions depending on the primary site of involvement. Cross-entity comparisons of the MZ Ig sequence dataset with a large dataset of Ig sequences (MZ-related or not; n = 65 837) revealed four major clusters of cases sharing homologous ('public') heavy variable complementarity-determining region 3. These clusters included rearrangements from SMZL, ENMZL (gastric, salivary gland, ocular adnexa), chronic lymphocytic leukemia, but also rheumatoid factors and non-malignant splenic MZ cells. In conclusion, different MZ lymphomas display biased immunogenetic signatures indicating distinct antigen exposure histories. The existence of rare public stereotypes raises the intriguing possibility that common, pathogen-triggered, immune-mediated mechanisms may result in diverse B lymphoproliferations due to targeting versatile progenitor B cells and/or operating in particular microenvironments. Copyright (c) 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
ER -
XOCHELLI, A., Vasileios BIKOS, E. POLYCHRONIDOU, C. GALIGALIDOU, A. AGATHANGELIDIS, F. CHARLOTTE, P. MOSCHONAS, Z. DAVIS, M. COLOMBO, M. ROUMELIOTI, L.A. SUTTON, P. GROENEN, M. VAN DEN BRAND, M. BOUDJOGHRA, P. ALGARA, A. TRAVERSE-GLEHEN, A. FERRER, E. STALIKA, M. KARYPIDOU, G. KANELLIS, C. KALPADAKIS, M. MOLLEJO, G. PANGALIS, P. VLAMOS, R.M. AMINI, Šárka POSPÍŠILOVÁ, D. GONZALEZ, M. PONZONI, A. ANAGNOSTOPOULOS, V. GIUDICELLI, M.P. LEFRANC, B. ESPINET, P. PANAGIOTIDIS, M.A. PIRIS, M.Q. DU, R. ROSENQUIST, T. PAPADAKI, C. BELESSI, M. FERRARINI, D. OSCIER, D. TZOVARAS, P. GHIA, F. DAVI, A. HADZIDIMITRIOU a K. STAMATOPOULOS. Disease-biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations. \textit{JOURNAL OF PATHOLOGY}. HOBOKEN: WILEY-BLACKWELL, 2019, roč.~247, č.~4, s.~416-421. ISSN~0022-3417. Dostupné z: https://dx.doi.org/10.1002/path.5209.
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