Prenatal Stress, Mood, and Gray Matter Volume in Young
Adulthood

J 2019

Prenatal Stress, Mood, and Gray Matter Volume in Young Adulthood

MAREČKOVÁ, Klára, A. KLASNJA, Petra BENCÚROVÁ, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL et. al.

Basic information

Original name

Prenatal Stress, Mood, and Gray Matter Volume in Young Adulthood

Authors

MAREČKOVÁ, Klára (203 Czech Republic, guarantor, belonging to the institution), A. KLASNJA (124 Canada), Petra BENCÚROVÁ (703 Slovakia, belonging to the institution), Lenka ANDRÝSKOVÁ (203 Czech Republic, belonging to the institution), Milan BRÁZDIL (203 Czech Republic, belonging to the institution) and T. PAUS (124 Canada)

Edition

CEREBRAL CORTEX, CARY, OXFORD UNIV PRESS INC, 2019, 1047-3211

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.043

RIV identification code

RIV/00216224:14740/19:00109679

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1093/cercor/bhy030

UT WoS

000462494100025

Keywords in English

European longitudinal study of pregnancy and childhood mood dysregulation; gray matter volume; magnetic resonance imaging; prenatal stress

Abstract

V originále

This study aimed to determine whether prenatal stress, measured by the number of stressful life events during the first 20 weeks of pregnancy, might relate to mood dysregulation and altered brain structure in young adulthood. Participants included 93 young adults from a community-based birth cohort from the Czech Republic. Information on prenatal stress exposure was collected from their mothers in 1990-1992. Magnetic resonance imaging (MRI) and mood-related data were collected from the young adults in 2015. MRI analyses focused on overall gray matter (GM) volume and GM volume of cortical regions previously associated with major depression. Higher prenatal stress predicted more mood dysregulation, lower overall GM volume, and lower GM volume in mid-dorsolateral frontal cortex, anterior cingulate cortex, and precuneus in young adulthood. We observed no prenatal stress by sex interactions for any of the relations. We conclude that prenatal stress is an important risk factor that relates to worse mood states and altered brain structure in young adulthood irrespective of sex. Our results point to the importance and long-lasting effects of prenatal programming and suggest that offspring of mothers who went through substantial stress during pregnancy might benefit from early intervention that would reduce the odds of mental illness in later life.

Links

LM2015051, research and development project

Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

MAREČKOVÁ, Klára, A. KLASNJA, Petra BENCÚROVÁ, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL and T. PAUS. Prenatal Stress, Mood, and Gray Matter Volume in Young Adulthood. CEREBRAL CORTEX. CARY: OXFORD UNIV PRESS INC, 2019, vol. 29, No 3, p. 1244-1250. ISSN 1047-3211. Available from: https://dx.doi.org/10.1093/cercor/bhy030.

@article{1531776,
   author = {Marečková, Klára and Klasnja, A. and Bencúrová, Petra and Andrýsková, Lenka and Brázdil, Milan and Paus, T.},
   article_location = {CARY},
   article_number = {3},
   doi = {http://dx.doi.org/10.1093/cercor/bhy030},
   keywords = {European longitudinal study of pregnancy and childhood mood dysregulation; gray matter volume; magnetic resonance imaging; prenatal stress},
   language = {eng},
   issn = {1047-3211},
   journal = {CEREBRAL CORTEX},
   title = {Prenatal Stress, Mood, and Gray Matter Volume in Young Adulthood},
   url = {https://academic.oup.com/cercor/article-abstract/29/3/1244/4841691?redirectedFrom=fulltext},
   volume = {29},
   year = {2019}
}

TY  - JOUR
ID  - 1531776
AU  - Marečková, Klára - Klasnja, A. - Bencúrová, Petra - Andrýsková, Lenka - Brázdil, Milan - Paus, T.
PY  - 2019
TI  - Prenatal Stress, Mood, and Gray Matter Volume in Young Adulthood
JF  - CEREBRAL CORTEX
VL  - 29
IS  - 3
SP  - 1244-1250
EP  - 1244-1250
PB  - OXFORD UNIV PRESS INC
SN  - 10473211
KW  - European longitudinal study of pregnancy and childhood mood dysregulation
KW  - gray matter volume
KW  - magnetic resonance imaging
KW  - prenatal stress
UR  - https://academic.oup.com/cercor/article-abstract/29/3/1244/4841691?redirectedFrom=fulltext
L2  - https://academic.oup.com/cercor/article-abstract/29/3/1244/4841691?redirectedFrom=fulltext
N2  - This study aimed to determine whether prenatal stress, measured by the number of stressful life events during the first 20 weeks of pregnancy, might relate to mood dysregulation and altered brain structure in young adulthood. Participants included 93 young adults from a community-based birth cohort from the Czech Republic. Information on prenatal stress exposure was collected from their mothers in 1990-1992. Magnetic resonance imaging (MRI) and mood-related data were collected from the young adults in 2015. MRI analyses focused on overall gray matter (GM) volume and GM volume of cortical regions previously associated with major depression. Higher prenatal stress predicted more mood dysregulation, lower overall GM volume, and lower GM volume in mid-dorsolateral frontal cortex, anterior cingulate cortex, and precuneus in young adulthood. We observed no prenatal stress by sex interactions for any of the relations. We conclude that prenatal stress is an important risk factor that relates to worse mood states and altered brain structure in young adulthood irrespective of sex. Our results point to the importance and long-lasting effects of prenatal programming and suggest that offspring of mothers who went through substantial stress during pregnancy might benefit from early intervention that would reduce the odds of mental illness in later life.
ER  -

MAREČKOVÁ, Klára, A. KLASNJA, Petra BENCÚROVÁ, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL and T. PAUS. Prenatal Stress, Mood, and Gray Matter Volume in Young Adulthood. \textit{CEREBRAL CORTEX}. CARY: OXFORD UNIV PRESS INC, 2019, vol.~29, No~3, p.~1244-1250. ISSN~1047-3211. Available from: https://dx.doi.org/10.1093/cercor/bhy030.

Detailed Information on Publication Record