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@article{1534738, author = {Procházková, Jiřina and Strapáčová, Simona and Svržková, Lucie and Andrysík, Zdeněk and Hyzdalova, Martina and Hrubá, Eva and Pěnčíková, Kateřina and Libalova, H and Topinka, J and Kléma, Jiří and Espinosa, JM and Vondráček, Jan and Machala, Miroslav}, article_location = {CLARE}, doi = {http://dx.doi.org/10.1016/j.toxlet.2018.04.024}, keywords = {Aryl hydrocarbon receptor; Lung cancer; Dioxins; Global gene expression profiling}, language = {eng}, issn = {0378-4274}, journal = {Toxicology Letters}, title = {Adaptive changes in global gene expression profile of lung carcinoma A549 cells acutely exposed to distinct types of AhR ligands}, url = {http://dx.doi.org/10.1016/j.toxlet.2018.04.024}, volume = {292}, year = {2018} }
TY - JOUR ID - 1534738 AU - Procházková, Jiřina - Strapáčová, Simona - Svržková, Lucie - Andrysík, Zdeněk - Hyzdalova, Martina - Hrubá, Eva - Pěnčíková, Kateřina - Libalova, H - Topinka, J - Kléma, Jiří - Espinosa, JM - Vondráček, Jan - Machala, Miroslav PY - 2018 TI - Adaptive changes in global gene expression profile of lung carcinoma A549 cells acutely exposed to distinct types of AhR ligands JF - Toxicology Letters VL - 292 SP - 162-174 EP - 162-174 PB - Elsevier SN - 03784274 KW - Aryl hydrocarbon receptor KW - Lung cancer KW - Dioxins KW - Global gene expression profiling UR - http://dx.doi.org/10.1016/j.toxlet.2018.04.024 L2 - http://dx.doi.org/10.1016/j.toxlet.2018.04.024 N2 - Exposure to persistent ligands of aryl hydrocarbon receptor (AhR) has been found to cause lung cancer in experimental animals, and lung adenocarcinomas are often associated with enhanced AhR expression and aberrant AhR activation. In order to better understand the action of toxic AhR ligands in lung epithelial cells, we performed global gene expression profiling and analyze TCDD-induced changes in A549 transcriptome, both sensitive and non-sensitive to CH223191 co-treatment. Comparison of our data with results from previously reported microarray and ChIP-seq experiments enabled us to identify candidate genes, which expression status reflects exposure of lung cancer cells to TCDD, and to predict processes, pathways (e.g. ER stress, Wnt/beta-cat, IFN., EGFR/Erbb1), putative TFs (e.g. STAT, AP1, E2F1, TCF4), which may be implicated in adaptive response of lung cells to TCDD-induced AhR activation. Importantly, TCDD-like expression fingerprint of selected genes was observed also in A549 cells exposed acutely to both toxic (benzo[ a] pyrene, benzo[k] fluoranthene) and endogenous AhR ligands (2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester and 6-formylindolo [3,2-b] carbazole). Overall, our results suggest novel cellular candidates, which could help to improve monitoring of AhR-dependent transcriptional activity during acute exposure of lung cells to distinct types of environmental pollutants. ER -
PROCHÁZKOVÁ, Jiřina, Simona STRAPÁČOVÁ, Lucie SVRŽKOVÁ, Zdeněk ANDRYSÍK, Martina HYZDALOVA, Eva HRUBÁ, Kateřina PĚNČÍKOVÁ, H LIBALOVA, J TOPINKA, Jiří KLÉMA, JM ESPINOSA, Jan VONDRÁČEK and Miroslav MACHALA. Adaptive changes in global gene expression profile of lung carcinoma A549 cells acutely exposed to distinct types of AhR ligands. \textit{Toxicology Letters}. CLARE: Elsevier, 2018, vol.~292, p.~162-174. ISSN~0378-4274. Available from: https://dx.doi.org/10.1016/j.toxlet.2018.04.024.
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