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@article{1535701,
author = {Dražanová, Eva and Rudá, Jana and Krátká, Lucie and Štark, Tibor and Kuchař, Martin and Maryška, Michal and Drago, Filippo and Starčuk, Zenon and Micale, Vincenzo},
article_location = {London},
article_number = {6062},
doi = {http://dx.doi.org/10.1038/s41598-019-42532-z},
keywords = {METHYLAZOXYMETHANOL ACETATE; ANIMAL-MODELS; BRAIN STRUCTURE; CANNABIS USE; SCHIZOPHRENIA; FLOW; METAANALYSIS; SYMPTOMS; DELTA(9)-TETRAHYDROCANNABINOL; DELTA-9-TETRAHYDROCANNABINOL},
language = {eng},
issn = {2045-2322},
journal = {Scientific reports},
title = {Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats},
url = {https://www.nature.com/articles/s41598-019-42532-z},
volume = {9},
year = {2019}
}
TY - JOUR
ID - 1535701
AU - Dražanová, Eva - Rudá, Jana - Krátká, Lucie - Štark, Tibor - Kuchař, Martin - Maryška, Michal - Drago, Filippo - Starčuk, Zenon - Micale, Vincenzo
PY - 2019
TI - Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats
JF - Scientific reports
VL - 9
IS - 6062
SP - 1-10
EP - 1-10
PB - NATURE PUBLISHING GROUP
SN - 20452322
KW - METHYLAZOXYMETHANOL ACETATE
KW - ANIMAL-MODELS
KW - BRAIN STRUCTURE
KW - CANNABIS USE
KW - SCHIZOPHRENIA
KW - FLOW
KW - METAANALYSIS
KW - SYMPTOMS
KW - DELTA(9)-TETRAHYDROCANNABINOL
KW - DELTA-9-TETRAHYDROCANNABINOL
UR - https://www.nature.com/articles/s41598-019-42532-z
L2 - https://www.nature.com/articles/s41598-019-42532-z
N2 - Clinical studies consistently report structural impairments (i.e.: ventricular enlargement, decreased volume of anterior cingulate cortex or hippocampus) and functional abnormalities including changes in regional cerebral blood flow in individuals suffering from schizophrenia, which can be evaluated by magnetic resonance imaging (MRI) techniques. The aim of this study was to assess cerebral blood perfusion in several schizophrenia-related brain regions using Arterial Spin Labelling MRI (ASL MRI, 9.4 T Bruker BioSpec 94/30USR scanner) in rats. In this study, prenatal exposure to methylazoxymethanol acetate (MAM, 22 mg/kg) at gestational day (GD) 17 and the perinatal treatment with Delta-9-tetrahydrocannabinol (THC, 5 mg/kg) from GD15 to postnatal day 9 elicited behavioral deficits consistent with schizophrenia-like phenotype, which is in agreement with the neurodevelopmental hypothesis of schizophrenia. In MAM exposed rats a significant enlargement of lateral ventricles and perfusion changes (i.e.: increased blood perfusion in the circle of Willis and sensorimotor cortex and decreased perfusion in hippocampus) were detected. On the other hand, the THC perinatally exposed rats did not show differences in the cerebral blood perfusion in any region of interest. These results suggest that although both pre/perinatal insults showed some of the schizophrenia-like deficits, these are not strictly related to distinct hemodynamic features.
ER -
DRAŽANOVÁ, Eva, Jana RUDÁ, Lucie KRÁTKÁ, Tibor ŠTARK, Martin KUCHAŘ, Michal MARYŠKA, Filippo DRAGO, Zenon STARČUK and Vincenzo MICALE. Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats. \textit{Scientific reports}. London: NATURE PUBLISHING GROUP, 2019, vol.~9, No~6062, p.~1-10. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-019-42532-z.
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