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@article{1538496,
author = {Kučera, Jan and Rudá, Jana and Zlámal, Filip and Kuruczová, Daniela and Babinská, Zuzana and Tomandl, Josef and Tomandlová, Marie and Dobrovolná, Julie},
article_location = {KRAKOW},
article_number = {4},
doi = {http://dx.doi.org/10.1016/j.pharep.2019.03.005},
keywords = {BDNF; GDNF; Neurotrophins; Olfactory bulbectomy; Rats},
language = {eng},
issn = {1734-1140},
journal = {Pharmacological Reports},
title = {Oral administration of BDNF and/or GDNF normalizes serum BDNF level in the olfactory bulbectomized rats: A proof of concept study},
url = {https://www.sciencedirect.com/science/article/pii/S1734114018305516?via%3Dihub},
volume = {71},
year = {2019}
}
TY - JOUR
ID - 1538496
AU - Kučera, Jan - Rudá, Jana - Zlámal, Filip - Kuruczová, Daniela - Babinská, Zuzana - Tomandl, Josef - Tomandlová, Marie - Dobrovolná, Julie
PY - 2019
TI - Oral administration of BDNF and/or GDNF normalizes serum BDNF level in the olfactory bulbectomized rats: A proof of concept study
JF - Pharmacological Reports
VL - 71
IS - 4
SP - 669-675
EP - 669-675
PB - POLISH ACAD SCIENCES INST PHARMACOLOGY
SN - 17341140
KW - BDNF
KW - GDNF
KW - Neurotrophins
KW - Olfactory bulbectomy
KW - Rats
UR - https://www.sciencedirect.com/science/article/pii/S1734114018305516?via%3Dihub
L2 - https://www.sciencedirect.com/science/article/pii/S1734114018305516?via%3Dihub
N2 - Background: Neurotrophins, especially brain-derived neurotrophic factor (BDNF) have gained significant therapeutic interest particularly in neurologic and psychiatric disorders and they have been found in human breast milk of mothers who suffered from adverse outcomes in pregnancy. This study tested the hypothesis that oral administration of BDNF/GDNF (glial cell line-derived neurotrophic factor) can exert a biological effect in a rat model of severe neuropathology induced by olfactory bulbectomy (OBX), which exhibits dysregulation of BDNF signaling and impaired blood-brain barrier. Methods: Adult male albino Sprague-Dawley rats underwent the OBX surgery and separate groups of OBX and sham-operated controls received one oral dose of vehicle, BDNF (0.005 mg/kg), GDNF (0.03 mg/kg) or their combination. One week after neurotrophin dosing the rats were sacrificed and BDNF level was assessed by ELISA in the blood serum and cerebrospinal fluid. Results: A significant decrease of serum BDNF level was found in the OBX model. This alteration was normalized by all types of treatment BDNF, GDNF, or their combination. No influence of sham surgery or treatment was observed in the control rats. BDNF levels in cerebrospinal fluid were below detection limit. Conclusion: This study indicates that oral administration of neurotrophins is able to exert a biological effect in the OBX model. There is a number of potential mechanisms, which remain to be elucidated.
ER -
KUČERA, Jan, Jana RUDÁ, Filip ZLÁMAL, Daniela KURUCZOVÁ, Zuzana BABINSKÁ, Josef TOMANDL, Marie TOMANDLOVÁ and Julie DOBROVOLNÁ. Oral administration of BDNF and/or GDNF normalizes serum BDNF level in the olfactory bulbectomized rats: A proof of concept study. \textit{Pharmacological Reports}. KRAKOW: POLISH ACAD SCIENCES INST PHARMACOLOGY, vol.~71, No~4, p.~669-675. ISSN~1734-1140. doi:10.1016/j.pharep.2019.03.005. 2019.
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