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@article{1538922,
author = {Rájecká, Veronika and Skalický, Tomáš and Vaňáčová, Štěpánka},
article_location = {Amsterdam},
article_number = {3},
doi = {http://dx.doi.org/10.1016/j.bbagrm.2018.12.001},
keywords = {m(6)A; m(6)A(m); RNA demethylase; FTO; ALKBH5; RNA modification},
language = {eng},
issn = {1874-9399},
journal = {Biochimica et biophysica acta - Gene regulatory mechanisms},
title = {The role of RNA adenosine demethylases in the control of gene expression},
url = {https://www.sciencedirect.com/science/article/pii/S1874939918300439?via%3Dihub},
volume = {1862},
year = {2019}
}
TY - JOUR
ID - 1538922
AU - Rájecká, Veronika - Skalický, Tomáš - Vaňáčová, Štěpánka
PY - 2019
TI - The role of RNA adenosine demethylases in the control of gene expression
JF - Biochimica et biophysica acta - Gene regulatory mechanisms
VL - 1862
IS - 3
SP - 343-355
EP - 343-355
PB - Elsevier
SN - 18749399
KW - m(6)A
KW - m(6)A(m)
KW - RNA demethylase
KW - FTO
KW - ALKBH5
KW - RNA modification
UR - https://www.sciencedirect.com/science/article/pii/S1874939918300439?via%3Dihub
L2 - https://www.sciencedirect.com/science/article/pii/S1874939918300439?via%3Dihub
N2 - RNA modifications are being recognized as an essential factor in gene expression regulation. They play essential roles in germ line development, differentiation and disease. In eukaryotic mRNAs, N-6-adenosine methylation (m(6)A) is the most prevalent internal chemical modification identified to date. The m(6)A pathway involves factors called writers, readers and erasers. m(6)A thus offers an interesting concept of dynamic reversible modification with implications in fine-tuning the cellular metabolism. In mammals, FTO and ALKBH5 have been initially identified as m(6)A erasers. Recently, FTO m(6)A specificity has been debated as new reports identify FTO targeting N-6,2'-O-dimethyladenosine (m(6)A(m)). The two adenosine demethylases have diverse roles in the metabolism of mRNAs and their activity is involved in key processes, such as embryogenesis, disease or infection. In this article, we review the current knowledge of their function and mechanisms and discuss the existing contradictions in the field. This article is part of a Special Issue entitled: mRNA modifications in gene expression control edited by Dr. Soller Matthias and Dr. Fray Rupert.
ER -
RÁJECKÁ, Veronika, Tomáš SKALICKÝ and Štěpánka VAŇÁČOVÁ. The role of RNA adenosine demethylases in the control of gene expression. \textit{Biochimica et biophysica acta - Gene regulatory mechanisms}. Amsterdam: Elsevier, 2019, vol.~1862, No~3, p.~343-355. ISSN~1874-9399. Available from: https://dx.doi.org/10.1016/j.bbagrm.2018.12.001.
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