| ANDRAŠINA, Tomáš, Tomáš GROLICH, Michal CRHA, Ladislav STEHLIK, Tomáš ROHAN, Červinka DALIBOR, Veronika NOVOTNÁ, Vladan BERNARD, Iva SVOBODOVÁ and Vlastimil VÁLEK. The Methodology for Endoluminal Irreversible Electroporation in Porcine Models. Acta Veterinaria Brno. Brno: Veterinární a farmaceutická univerzita Brno, 2019, vol. 88, No 2, p. 201-211. ISSN 0001-7213. Available from: https://dx.doi.org/10.2754/avb201988020201. |
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@article{1541718,
author = {Andrašina, Tomáš and Grolich, Tomáš and Crha, Michal and Stehlik, Ladislav and Rohan, Tomáš and Dalibor, Červinka and Novotná, Veronika and Bernard, Vladan and Svobodová, Iva and Válek, Vlastimil},
article_location = {Brno},
article_number = {2},
doi = {http://dx.doi.org/10.2754/avb201988020201},
keywords = {biliary ablation; magnetic resonance imaging; intraductal ablation; experimental study},
language = {eng},
issn = {0001-7213},
journal = {Acta Veterinaria Brno},
title = {The Methodology for Endoluminal Irreversible Electroporation in Porcine Models},
url = {http://dx.doi.org/10.2754/avb201988020201},
volume = {88},
year = {2019}
}
TY - JOUR
ID - 1541718
AU - Andrašina, Tomáš - Grolich, Tomáš - Crha, Michal - Stehlik, Ladislav - Rohan, Tomáš - Dalibor, Červinka - Novotná, Veronika - Bernard, Vladan - Svobodová, Iva - Válek, Vlastimil
PY - 2019
TI - The Methodology for Endoluminal Irreversible Electroporation in Porcine Models
JF - Acta Veterinaria Brno
VL - 88
IS - 2
SP - 201-211
EP - 201-211
PB - Veterinární a farmaceutická univerzita Brno
SN - 00017213
KW - biliary ablation
KW - magnetic resonance imaging
KW - intraductal ablation
KW - experimental study
UR - http://dx.doi.org/10.2754/avb201988020201
L2 - http://dx.doi.org/10.2754/avb201988020201
N2 - The aim of work was to describe methodology of surgical technique for endoluminal irreversible electroporation in the biliary tract performed within the perihilar region in porcine models. Endoluminal irreversible electroporation of the common bile duct was performed on 8 porcine models using an endoluminal device inserted during laparotomy. The endoluminal device consisted of 3 electrodes 1 cm in length, attached at 120 degrees around the balloon catheter. The procedure was conducted with following parameters: number of pulses 90, voltage of 1500 V between each couple of electrodes. Cross sectional imaging and histopathological assessment were employed for evaluations of ablation zone. Models were sacrificed in 24 hours and 96 hours after ablation. The treatment was successful in all porcine models. All animals survived the defined study period. Peri-ablation oedema within the hepatoduodenal ligament and adjacent liver tissue could be measured on post-procedural MRI or CT. Perforation in site of ablation developed in one model. Histopathological examination showed heavy regressive changes of ablated tissue. The elastic membranes of adjacent portal vein were preserved in all models. This novel endoluminal modality used within the perihilar region on porcine models is a feasible and well predictable procedure according to our experience. Further studies should explore the optimal protocol of catheter-based ablation to limit complications.
ER -
ANDRAŠINA, Tomáš, Tomáš GROLICH, Michal CRHA, Ladislav STEHLIK, Tomáš ROHAN, Červinka DALIBOR, Veronika NOVOTNÁ, Vladan BERNARD, Iva SVOBODOVÁ and Vlastimil VÁLEK. The Methodology for Endoluminal Irreversible Electroporation in Porcine Models. \textit{Acta Veterinaria Brno}. Brno: Veterinární a farmaceutická univerzita Brno, 2019, vol.~88, No~2, p.~201-211. ISSN~0001-7213. Available from: https://dx.doi.org/10.2754/avb201988020201.
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