| THAI LE, Son, Lenka MALINOVSKÁ, Michaela VAŠKOVÁ, Erika MEZO, Viktor KELEMEN, Anikó BORBÁS, Petr HODEK, Michaela WIMMEROVÁ and Magdolna CSÁVÁS. Investigation of the Binding Affinity of a Broad Array of L-Fucosides with Six Fucose-Specific Lectins of Bacterial and Fungal Origin. Molecules. Mayer und Muller, 2019, vol. 24, No 12, p. 1-17. ISSN 1420-3049. Available from: https://dx.doi.org/10.3390/molecules24122262. |
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@article{1543778,
author = {Thai Le, Son and Malinovská, Lenka and Vašková, Michaela and Mezo, Erika and Kelemen, Viktor and Borbás, Anikó and Hodek, Petr and Wimmerová, Michaela and Csávás, Magdolna},
article_number = {12},
doi = {http://dx.doi.org/10.3390/molecules24122262},
keywords = {l-fucosides; multivalency; lectins; glycoclusters; hemagglutination; cystic fibrosis},
language = {eng},
issn = {1420-3049},
journal = {Molecules},
title = {Investigation of the Binding Affinity of a Broad Array of L-Fucosides with Six Fucose-Specific Lectins of Bacterial and Fungal Origin},
url = {https://www.mdpi.com/1420-3049/24/12/2262},
volume = {24},
year = {2019}
}
TY - JOUR
ID - 1543778
AU - Thai Le, Son - Malinovská, Lenka - Vašková, Michaela - Mezo, Erika - Kelemen, Viktor - Borbás, Anikó - Hodek, Petr - Wimmerová, Michaela - Csávás, Magdolna
PY - 2019
TI - Investigation of the Binding Affinity of a Broad Array of L-Fucosides with Six Fucose-Specific Lectins of Bacterial and Fungal Origin
JF - Molecules
VL - 24
IS - 12
SP - 1-17
EP - 1-17
PB - Mayer und Muller
SN - 14203049
KW - l-fucosides
KW - multivalency
KW - lectins
KW - glycoclusters
KW - hemagglutination
KW - cystic fibrosis
UR - https://www.mdpi.com/1420-3049/24/12/2262
L2 - https://www.mdpi.com/1420-3049/24/12/2262
N2 - Series of multivalent alpha-l-fucoside containing glycoclusters and variously decorated l-fucosides were synthesized to find potential inhibitors of fucose-specific lectins and study the structure-binding affinity relationships. Tri- and tetravalent fucoclusters were built using copper-mediated azide-alkyne click chemistry. Series of fucoside monomers and dimers were synthesized using various methods, namely glycosylation, an azide-alkyne click reaction, photoinduced thiol-en addition, and sulfation. The interactions between compounds with six fucolectins of bacterial or fungal origin were tested using a hemagglutination inhibition assay. As a result, a tetravalent, aplha-l-fucose presenting glycocluster showed to be a ligand that was orders of magnitude better than a simple monosaccharide for tested lectins in most cases, which can nominate it as a universal ligand for studied lectins. This compound was also able to inhibit the adhesion of Pseudomonas aeruginosa cells to human epithelial bronchial cells. A trivalent fucocluster with a protected amine functional group also seems to be a promising candidate for designing glycoconjugates and chimeras.
ER -
THAI LE, Son, Lenka MALINOVSKÁ, Michaela VAŠKOVÁ, Erika MEZO, Viktor KELEMEN, Anikó BORBÁS, Petr HODEK, Michaela WIMMEROVÁ and Magdolna CSÁVÁS. Investigation of the Binding Affinity of a Broad Array of L-Fucosides with Six Fucose-Specific Lectins of Bacterial and Fungal Origin. \textit{Molecules}. Mayer und Muller, 2019, vol.~24, No~12, p.~1-17. ISSN~1420-3049. Available from: https://dx.doi.org/10.3390/molecules24122262.
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