Detailed Information on Publication Record
2019
Impaired Self-Other Distinction and Subcortical Gray-Matter Alterations Characterize Socio-Cognitive Disturbances in Multiple Sclerosis
CZEKÓOVÁ, Kristína, Daniel Joel SHAW, Kristína SAXUNOVÁ, Michal DUFEK, Radek MAREČEK et. al.Basic information
Original name
Impaired Self-Other Distinction and Subcortical Gray-Matter Alterations Characterize Socio-Cognitive Disturbances in Multiple Sclerosis
Authors
CZEKÓOVÁ, Kristína (703 Slovakia, belonging to the institution), Daniel Joel SHAW (826 United Kingdom of Great Britain and Northern Ireland, belonging to the institution), Kristína SAXUNOVÁ (703 Slovakia, belonging to the institution), Michal DUFEK (203 Czech Republic, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Jiří VANÍČEK (203 Czech Republic, belonging to the institution) and Milan BRÁZDIL (203 Czech Republic, guarantor, belonging to the institution)
Edition
FRONTIERS IN NEUROLOGY, LAUSANNE, FRONTIERS MEDIA SA, 2019, 1664-2295
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30210 Clinical neurology
Country of publisher
Switzerland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 2.889
RIV identification code
RIV/00216224:14740/19:00107485
Organization unit
Central European Institute of Technology
UT WoS
000468416300001
Keywords in English
multiple sclerosis; social cognition; self-other distinction; automatic imitation; visual perspective taking; voxel-based morphometry; gray-matter volume
Tags
International impact, Reviewed
Změněno: 8/10/2024 08:42, Ing. Jana Kuchtová
Abstract
V originále
Introduction: Recent studies of patients with multiple sclerosis (MS) have revealed disturbances in distinct components of social cognition, such as impaired mentalizing and empathy. The present study investigated this socio-cognitive profile in MS patients in more detail, by examining their performance on tasks measuring more fundamental components of social cognition and any associated disruptions to gray-matter volume (GMV). Methods: We compared 43 patients with relapse-remitting MS with 43 age- and sex-matched healthy controls (HCs) on clinical characteristics (depression, fatigue), cognitive processing speed, and three aspects of low-level social cognition; specifically, imitative tendencies, visual perspective taking, and emotion recognition. Using voxel-based morphometry, we then explored relationships between GMV and these clinical and behavioral measures. Results: Patients exhibited significantly slower processing speed, poorer perspective taking, and less imitation compared with HCs. These impairments were related to reduced GMV throughout the putamen, thalami, and anterior insula, predominantly in the left hemisphere. Surprisingly, differences between the groups in emotion recognition were not significant. Conclusion: Less imitation and poorer perspective taking indicate a cognitive self-bias when faced with conflicting self-and other-representations. This suggests that impaired self-other distinction, and an associated subcortical pattern of GM atrophy, might underlie the socio-cognitive disturbances observed in MS.
Links
| GA15-16738S, research and development project |
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| 90062, large research infrastructures |
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