| VEVERKA, Pavel, Tomáš JANOVIČ a Ctirad HOFR. Quantitative Biology of Human Shelterin and Telomerase: Searching for the Weakest Point. International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute, 2019, roč. 20, č. 13, s. 1-13. ISSN 1422-0067. doi:10.3390/ijms20133186. |
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@article{1545296,
author = {Veverka, Pavel and Janovič, Tomáš and Hofr, Ctirad},
article_location = {Basel},
article_number = {13},
doi = {http://dx.doi.org/10.3390/ijms20133186},
keywords = {telomerase; shelterin; telomere; quantitative biology; protein-protein interaction; protein-DNA interaction; assembly; inhibitor; anticancer},
language = {eng},
issn = {1422-0067},
journal = {International Journal of Molecular Sciences},
title = {Quantitative Biology of Human Shelterin and Telomerase: Searching for the Weakest Point},
url = {https://doi.org/10.3390/ijms20133186},
volume = {20},
year = {2019}
}
TY - JOUR
ID - 1545296
AU - Veverka, Pavel - Janovič, Tomáš - Hofr, Ctirad
PY - 2019
TI - Quantitative Biology of Human Shelterin and Telomerase: Searching for the Weakest Point
JF - International Journal of Molecular Sciences
VL - 20
IS - 13
SP - 1-13
EP - 1-13
PB - Multidisciplinary Digital Publishing Institute
SN - 14220067
KW - telomerase
KW - shelterin
KW - telomere
KW - quantitative biology
KW - protein-protein interaction
KW - protein-DNA interaction
KW - assembly
KW - inhibitor
KW - anticancer
UR - https://doi.org/10.3390/ijms20133186
L2 - https://doi.org/10.3390/ijms20133186
N2 - The repetitive telomeric DNA at chromosome ends is protected from unwanted repair by telomere-associated proteins, which form the shelterin complex in mammals. Recent works have provided new insights into the mechanisms of how human shelterin assembles and recruits telomerase to telomeres. Inhibition of telomerase activity and telomerase recruitment to chromosome ends is a promising target for anticancer therapy. Here, we summarize results of quantitative assessments and newly emerged structural information along with the status of the most promising approaches to telomerase inhibition in cancer cells. We focus on the mechanism of shelterin assembly and the mechanisms of how shelterin affects telomerase recruitment to telomeres, addressing the conceptual dilemma of how shelterin allows telomerase action and regulates other essential processes. We evaluate how the identified critical interactions of telomerase and shelterin might be elucidated in future research of new anticancer strategies.
ER -
VEVERKA, Pavel, Tomáš JANOVIČ a Ctirad HOFR. Quantitative Biology of Human Shelterin and Telomerase: Searching for the Weakest Point. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2019, roč.~20, č.~13, s.~1-13. ISSN~1422-0067. doi:10.3390/ijms20133186.
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