J 2019

Neural Scaffolding as the Foundation for Stable Performance of Aging Cerebellum

FILIP, Pavel, Cécile GALLEA, Stéphane LEHERICY, Ovidiu LUNGU, Martin BAREŠ et. al.

Basic information

Original name

Neural Scaffolding as the Foundation for Stable Performance of Aging Cerebellum

Authors

FILIP, Pavel (703 Slovakia, guarantor, belonging to the institution), Cécile GALLEA (250 France), Stéphane LEHERICY (250 France), Ovidiu LUNGU (124 Canada) and Martin BAREŠ (203 Czech Republic, belonging to the institution)

Edition

Cerebellum, New York, Springer, 2019, 1473-4222

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 3.129

RIV identification code

RIV/00216224:14110/19:00110173

Organization unit

Faculty of Medicine

UT WoS

000468112900019

Keywords in English

Cerebellar aging; fMRI; Functional connectivity; Voxel-based morphometry

Tags

Tags

International impact, Reviewed
Změněno: 15/7/2019 13:27, Soňa Böhmová

Abstract

V originále

Although recently conceptualized as a neural node essential for a vast spectrum of associative and cognitive processes, the cerebellum has largely eluded attention in the research of aging, where it is marginalized mainly to structural analyses. In the current cross-sectional study of 67 healthy subjects of various ages (20 to 76 years), we sought to provide a comprehensive, multimodal account of age-related changes in the cerebellum during predictive motor timing, which was previously shown to engage this structure. We combined behavioral assessments of performance with functional MRI and voxel-based morphometry using an advanced method to avoid cerebellar deformation and registration imprecisions inherent to the standard processing at the whole-brain level. Higher age was surprisingly associated with stable behavioral performance during predictive motor timing, despite the massive decrease of infratentorial gray matter volume of a far higher extent than in the supratentorial region, affecting mainly the posterior cerebellar lobe. Nonetheless, this very area showed extensive hyperactivation directly correlated with age. The same region had decreased connectivity with the left caudate and increased connectivity with the left fusiform gyrus, the right pallidum, the hippocampus, and the lingual gyrus. Hence, we propose to extend the scaffolding theory of aging, previously limited mainly to the frontal cortices, to include also the cerebellum, which is likewise suffering from atrophy to a far greater extent than the rest of the brain and is similarly counteracting it by bilateral hyperactivation.