Detailed Information on Publication Record
2019
Neural Scaffolding as the Foundation for Stable Performance of Aging Cerebellum
FILIP, Pavel, Cécile GALLEA, Stéphane LEHERICY, Ovidiu LUNGU, Martin BAREŠ et. al.Basic information
Original name
Neural Scaffolding as the Foundation for Stable Performance of Aging Cerebellum
Authors
FILIP, Pavel (703 Slovakia, guarantor, belonging to the institution), Cécile GALLEA (250 France), Stéphane LEHERICY (250 France), Ovidiu LUNGU (124 Canada) and Martin BAREŠ (203 Czech Republic, belonging to the institution)
Edition
Cerebellum, New York, Springer, 2019, 1473-4222
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30103 Neurosciences
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 3.129
RIV identification code
RIV/00216224:14110/19:00110173
Organization unit
Faculty of Medicine
UT WoS
000468112900019
Keywords in English
Cerebellar aging; fMRI; Functional connectivity; Voxel-based morphometry
Tags
International impact, Reviewed
Změněno: 15/7/2019 13:27, Soňa Böhmová
Abstract
V originále
Although recently conceptualized as a neural node essential for a vast spectrum of associative and cognitive processes, the cerebellum has largely eluded attention in the research of aging, where it is marginalized mainly to structural analyses. In the current cross-sectional study of 67 healthy subjects of various ages (20 to 76 years), we sought to provide a comprehensive, multimodal account of age-related changes in the cerebellum during predictive motor timing, which was previously shown to engage this structure. We combined behavioral assessments of performance with functional MRI and voxel-based morphometry using an advanced method to avoid cerebellar deformation and registration imprecisions inherent to the standard processing at the whole-brain level. Higher age was surprisingly associated with stable behavioral performance during predictive motor timing, despite the massive decrease of infratentorial gray matter volume of a far higher extent than in the supratentorial region, affecting mainly the posterior cerebellar lobe. Nonetheless, this very area showed extensive hyperactivation directly correlated with age. The same region had decreased connectivity with the left caudate and increased connectivity with the left fusiform gyrus, the right pallidum, the hippocampus, and the lingual gyrus. Hence, we propose to extend the scaffolding theory of aging, previously limited mainly to the frontal cortices, to include also the cerebellum, which is likewise suffering from atrophy to a far greater extent than the rest of the brain and is similarly counteracting it by bilateral hyperactivation.