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@article{1545821,
author = {Bořilová Linhartová, Petra and Jánoš, Július and Poskerová, Hana and Kavříková, Denisa and Fassmann, Antonín and Dušek, Ladislav and Izakovičová Hollá, Lydie},
article_location = {SAO PAULO},
article_number = {e034},
doi = {http://dx.doi.org/10.1590/1807-3107bor-2019.vol33.0034},
keywords = {Chronic Periodontitis; Diabetes Mellitus; Type 2; Adipokines},
language = {eng},
issn = {1807-3107},
journal = {BRAZILIAN ORAL RESEARCH},
title = {Adipokine gene variability and plasma levels in patients with chronic periodontitis - a case-control study},
url = {http://dx.doi.org/10.1590/1807-3107bor-2019.vol33.0034},
volume = {33},
year = {2019}
}
TY - JOUR
ID - 1545821
AU - Bořilová Linhartová, Petra - Jánoš, Július - Poskerová, Hana - Kavříková, Denisa - Fassmann, Antonín - Dušek, Ladislav - Izakovičová Hollá, Lydie
PY - 2019
TI - Adipokine gene variability and plasma levels in patients with chronic periodontitis - a case-control study
JF - BRAZILIAN ORAL RESEARCH
VL - 33
IS - e034
SP - 1-12
EP - 1-12
PB - SOCIEDADE BRASILEIRA DE PESQUISA ODONTOLOGICA
SN - 18073107
KW - Chronic Periodontitis
KW - Diabetes Mellitus
KW - Type 2
KW - Adipokines
UR - http://dx.doi.org/10.1590/1807-3107bor-2019.vol33.0034
L2 - http://dx.doi.org/10.1590/1807-3107bor-2019.vol33.0034
N2 - Specific variants in genes that encode adipokines and their mRNA and protein expression were previously studied in type 2 diabetes mellitus (T2DM) and obesity, and similar studies have been performed for chronic periodontitis (CP). The aim of this case-control study was to investigate the possible impacts of adiponectin (ADIPOQ), leptin (LEP) and its receptor (LEPR), and resistin (RETN) on the etiopathogenesis of CP. Examinations were performed on 118 non-periodontitis healthy subjects (healthy controls, HC), 205 healthy individuals with CP (H + CP) and 86 type 2 diabetes patients with CP (T2DM + CP). Variants within the ADIPOQ (rs2241766, rs1501299), LEP (rs13228377, rs2167270), LEP receptor (rs1805096), and RETN (rs1862513) genes were determined by qPCR. In addition, the plasma levels of ADIPOQ, LEP, and RETN were analysed by ELISA for 80 individuals. The genotype frequencies of the SNP ADIPOQ + 45G/T (rs2241766) differed between the HC and H + CP groups (p=0.03, p(corr)>0.05), and carriers of the TT genotype had a lower risk of developing CP compared to carriers of the GG or TG genotypes (p<0.01, p(corr)>0.05). However, there were no significant differences in the plasma levels of ADIPOQ, LEP or RETN between the study groups (p > 0.05). Plasma levels of the adipokines were also independent of the gene profiles (p > 0.05). Adipokine plasma levels did not change in patients with H + CP/T2DM + CP compared to HC, but we did identify a specific polymorphism in the ADIPOQ gene that was associated with CP. Although the ADIPOQ + 45G/T (rs2241766) gene variant may be a candidate biomarker for CP, further research is required in larger populations with different ethnic backgrounds before any final conclusions can be drawn about the role of this gene in CP.
ER -
BOŘILOVÁ LINHARTOVÁ, Petra, Július JÁNOŠ, Hana POSKEROVÁ, Denisa KAVŘÍKOVÁ, Antonín FASSMANN, Ladislav DUŠEK and Lydie IZAKOVIČOVÁ HOLLÁ. Adipokine gene variability and plasma levels in patients with chronic periodontitis - a case-control study. \textit{BRAZILIAN ORAL RESEARCH}. SAO PAULO: SOCIEDADE BRASILEIRA DE PESQUISA ODONTOLOGICA, 2019, vol.~33, e034, p.~1-12. ISSN~1807-3107. Available from: https://dx.doi.org/10.1590/1807-3107bor-2019.vol33.0034.
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