Adipokine gene variability and plasma levels in patients with
chronic periodontitis - a case-control study

J 2019

Adipokine gene variability and plasma levels in patients with chronic periodontitis - a case-control study

BOŘILOVÁ LINHARTOVÁ, Petra, Július JÁNOŠ, Hana POSKEROVÁ, Denisa KAVŘÍKOVÁ, Antonín FASSMANN et. al.

Basic information

Original name

Adipokine gene variability and plasma levels in patients with chronic periodontitis - a case-control study

Authors

BOŘILOVÁ LINHARTOVÁ, Petra (203 Czech Republic, belonging to the institution), Július JÁNOŠ (703 Slovakia, belonging to the institution), Hana POSKEROVÁ (203 Czech Republic, belonging to the institution), Denisa KAVŘÍKOVÁ (203 Czech Republic, belonging to the institution), Antonín FASSMANN (203 Czech Republic, belonging to the institution), Ladislav DUŠEK (203 Czech Republic, belonging to the institution) and Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

BRAZILIAN ORAL RESEARCH, SAO PAULO, SOCIEDADE BRASILEIRA DE PESQUISA ODONTOLOGICA, 2019, 1807-3107

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30208 Dentistry, oral surgery and medicine

Country of publisher

Brazil

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.633

RIV identification code

RIV/00216224:14110/19:00107509

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1590/1807-3107bor-2019.vol33.0034

UT WoS

000468342300001

Keywords in English

Chronic Periodontitis; Diabetes Mellitus; Type 2; Adipokines

Abstract

V originále

Specific variants in genes that encode adipokines and their mRNA and protein expression were previously studied in type 2 diabetes mellitus (T2DM) and obesity, and similar studies have been performed for chronic periodontitis (CP). The aim of this case-control study was to investigate the possible impacts of adiponectin (ADIPOQ), leptin (LEP) and its receptor (LEPR), and resistin (RETN) on the etiopathogenesis of CP. Examinations were performed on 118 non-periodontitis healthy subjects (healthy controls, HC), 205 healthy individuals with CP (H + CP) and 86 type 2 diabetes patients with CP (T2DM + CP). Variants within the ADIPOQ (rs2241766, rs1501299), LEP (rs13228377, rs2167270), LEP receptor (rs1805096), and RETN (rs1862513) genes were determined by qPCR. In addition, the plasma levels of ADIPOQ, LEP, and RETN were analysed by ELISA for 80 individuals. The genotype frequencies of the SNP ADIPOQ + 45G/T (rs2241766) differed between the HC and H + CP groups (p=0.03, p(corr)>0.05), and carriers of the TT genotype had a lower risk of developing CP compared to carriers of the GG or TG genotypes (p<0.01, p(corr)>0.05). However, there were no significant differences in the plasma levels of ADIPOQ, LEP or RETN between the study groups (p > 0.05). Plasma levels of the adipokines were also independent of the gene profiles (p > 0.05). Adipokine plasma levels did not change in patients with H + CP/T2DM + CP compared to HC, but we did identify a specific polymorphism in the ADIPOQ gene that was associated with CP. Although the ADIPOQ + 45G/T (rs2241766) gene variant may be a candidate biomarker for CP, further research is required in larger populations with different ethnic backgrounds before any final conclusions can be drawn about the role of this gene in CP.

Links

GB14-37368G, research and development project

Name: Centrum orofaciálního vývoje a regenerace

Investor: Czech Science Foundation

MUNI/A/1008/2017, interní kód MU

Name: Etiopatogenetické aspekty, diagnostika a léčba vybraných onemocnění dutiny ústní

Investor: Masaryk University, Category A

MUNI/A/1546/2018, interní kód MU

Name: Etiopatogeneze, diagnostika a léčba vybraných onemocnění dutiny ústní a jejich souvislost s celkovým zdravotním stavem

Investor: Masaryk University, Category A

ROZV/25/LF/2017, interní kód MU

Name: LF - Příspěvek na IP 2017

Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects

Citovat

BOŘILOVÁ LINHARTOVÁ, Petra, Július JÁNOŠ, Hana POSKEROVÁ, Denisa KAVŘÍKOVÁ, Antonín FASSMANN, Ladislav DUŠEK and Lydie IZAKOVIČOVÁ HOLLÁ. Adipokine gene variability and plasma levels in patients with chronic periodontitis - a case-control study. BRAZILIAN ORAL RESEARCH. SAO PAULO: SOCIEDADE BRASILEIRA DE PESQUISA ODONTOLOGICA, 2019, vol. 33, e034, p. 1-12. ISSN 1807-3107. Available from: https://dx.doi.org/10.1590/1807-3107bor-2019.vol33.0034.

@article{1545821,
   author = {Bořilová Linhartová, Petra and Jánoš, Július and Poskerová, Hana and Kavříková, Denisa and Fassmann, Antonín and Dušek, Ladislav and Izakovičová Hollá, Lydie},
   article_location = {SAO PAULO},
   article_number = {e034},
   doi = {http://dx.doi.org/10.1590/1807-3107bor-2019.vol33.0034},
   keywords = {Chronic Periodontitis; Diabetes Mellitus; Type 2; Adipokines},
   language = {eng},
   issn = {1807-3107},
   journal = {BRAZILIAN ORAL RESEARCH},
   title = {Adipokine gene variability and plasma levels in patients with chronic periodontitis - a case-control study},
   url = {http://dx.doi.org/10.1590/1807-3107bor-2019.vol33.0034},
   volume = {33},
   year = {2019}
}

TY  - JOUR
ID  - 1545821
AU  - Bořilová Linhartová, Petra - Jánoš, Július - Poskerová, Hana - Kavříková, Denisa - Fassmann, Antonín - Dušek, Ladislav - Izakovičová Hollá, Lydie
PY  - 2019
TI  - Adipokine gene variability and plasma levels in patients with chronic periodontitis - a case-control study
JF  - BRAZILIAN ORAL RESEARCH
VL  - 33
IS  - e034
SP  - 1-12
EP  - 1-12
PB  - SOCIEDADE BRASILEIRA DE PESQUISA ODONTOLOGICA
SN  - 18073107
KW  - Chronic Periodontitis
KW  - Diabetes Mellitus
KW  - Type 2
KW  - Adipokines
UR  - http://dx.doi.org/10.1590/1807-3107bor-2019.vol33.0034
L2  - http://dx.doi.org/10.1590/1807-3107bor-2019.vol33.0034
N2  - Specific variants in genes that encode adipokines and their mRNA and protein expression were previously studied in type 2 diabetes mellitus (T2DM) and obesity, and similar studies have been performed for chronic periodontitis (CP). The aim of this case-control study was to investigate the possible impacts of adiponectin (ADIPOQ), leptin (LEP) and its receptor (LEPR), and resistin (RETN) on the etiopathogenesis of CP. Examinations were performed on 118 non-periodontitis healthy subjects (healthy controls, HC), 205 healthy individuals with CP (H + CP) and 86 type 2 diabetes patients with CP (T2DM + CP). Variants within the ADIPOQ (rs2241766, rs1501299), LEP (rs13228377, rs2167270), LEP receptor (rs1805096), and RETN (rs1862513) genes were determined by qPCR. In addition, the plasma levels of ADIPOQ, LEP, and RETN were analysed by ELISA for 80 individuals. The genotype frequencies of the SNP ADIPOQ + 45G/T (rs2241766) differed between the HC and H + CP groups (p=0.03, p(corr)>0.05), and carriers of the TT genotype had a lower risk of developing CP compared to carriers of the GG or TG genotypes (p<0.01, p(corr)>0.05). However, there were no significant differences in the plasma levels of ADIPOQ, LEP or RETN between the study groups (p > 0.05). Plasma levels of the adipokines were also independent of the gene profiles (p > 0.05). Adipokine plasma levels did not change in patients with H + CP/T2DM + CP compared to HC, but we did identify a specific polymorphism in the ADIPOQ gene that was associated with CP. Although the ADIPOQ + 45G/T (rs2241766) gene variant may be a candidate biomarker for CP, further research is required in larger populations with different ethnic backgrounds before any final conclusions can be drawn about the role of this gene in CP.
ER  -

BOŘILOVÁ LINHARTOVÁ, Petra, Július JÁNOŠ, Hana POSKEROVÁ, Denisa KAVŘÍKOVÁ, Antonín FASSMANN, Ladislav DUŠEK and Lydie IZAKOVIČOVÁ HOLLÁ. Adipokine gene variability and plasma levels in patients with chronic periodontitis - a case-control study. \textit{BRAZILIAN ORAL RESEARCH}. SAO PAULO: SOCIEDADE BRASILEIRA DE PESQUISA ODONTOLOGICA, 2019, vol.~33, e034, p.~1-12. ISSN~1807-3107. Available from: https://dx.doi.org/10.1590/1807-3107bor-2019.vol33.0034.

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