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@article{1545961,
author = {Kovacic, Alenka Premuš Marušič and Caprnda, Martin and Mrhar, Aleš and Kubatka, Peter and Locatelli, Igor and Zolakova, Barbora and Gaspar, Ludovit and Prosecký, Robert and Kružliak, Peter and Staffa, Robert and Rodrigo, Luis and Radonak, Jozef and Petrovic, Danijel},
article_location = {HEIDELBERG},
article_number = {6},
doi = {http://dx.doi.org/10.1007/s00228-019-02636-x},
keywords = {Venous thromboembolism; Analgesics; Diuretics; Antidepressants; Antipsychotics; Oral contraceptives; Surgery; Bridging anticoagulation; Transfusion; Thromboprophylaxis},
language = {eng},
issn = {0031-6970},
journal = {EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY},
title = {Impact of drugs on venous thromboembolism risk in surgical patients},
url = {http://dx.doi.org/10.1007/s00228-019-02636-x},
volume = {75},
year = {2019}
}
TY - JOUR
ID - 1545961
AU - Kovacic, Alenka Premuš Marušič - Caprnda, Martin - Mrhar, Aleš - Kubatka, Peter - Locatelli, Igor - Zolakova, Barbora - Gaspar, Ludovit - Prosecký, Robert - Kružliak, Peter - Staffa, Robert - Rodrigo, Luis - Radonak, Jozef - Petrovic, Danijel
PY - 2019
TI - Impact of drugs on venous thromboembolism risk in surgical patients
JF - EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
VL - 75
IS - 6
SP - 751-767
EP - 751-767
PB - SPRINGER HEIDELBERG
SN - 00316970
KW - Venous thromboembolism
KW - Analgesics
KW - Diuretics
KW - Antidepressants
KW - Antipsychotics
KW - Oral contraceptives
KW - Surgery
KW - Bridging anticoagulation
KW - Transfusion
KW - Thromboprophylaxis
UR - http://dx.doi.org/10.1007/s00228-019-02636-x
L2 - http://dx.doi.org/10.1007/s00228-019-02636-x
N2 - PurposeThis review focuses on the most common drugs administered to surgical patients during the perioperative period that affect the risk of venous thromboembolism (VTE).ResultsAmong analgesics, the risk of VTE is increased in patients treated with diclofenac, ibuprofen, and rofecoxib, but not naproxen, while metamizole can confer a protective effect. The relationship between sedatives and VTE has not been sufficiently studied. Tricyclic antidepressants, low-potency serotonin reuptake inhibitors, and antipsychotics have been associated with increased risk of VTE. The use of diuretics in the perioperative period is poorly researched; however, hyponatremia is considered a risk factor. Other factors that may influence the risk of VTE include bridging anticoagulation, allogeneic transfusion, and hemostatic management before surgery. Pharmacotherapy for HIV or cancer may also increase VTE risk.ConclusionIncreased monitoring for VTE is therefore advisable in surgical patients and those receiving antipsychotics, antidepressants, diuretics, or analgesics.
ER -
KOVACIC, Alenka Premuš Marušič, Martin CAPRNDA, Aleš MRHAR, Peter KUBATKA, Igor LOCATELLI, Barbora ZOLAKOVA, Ludovit GASPAR, Robert PROSECKÝ, Peter KRUŽLIAK, Robert STAFFA, Luis RODRIGO, Jozef RADONAK and Danijel PETROVIC. Impact of drugs on venous thromboembolism risk in surgical patients. \textit{EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY}. HEIDELBERG: SPRINGER HEIDELBERG, 2019, vol.~75, No~6, p.~751-767. ISSN~0031-6970. Available from: https://dx.doi.org/10.1007/s00228-019-02636-x.
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