Detailed Information on Publication Record
2019
Retinal photoreceptor apoptosis is associated with impaired serum ionized calcium homeostasis in diabetic retinopathy: An in-vivo analysis
ANKITA, A., Sandeep SAXENA, Dwividendra K. NIM, Jana STEFANICKOVA, Peter ZIAK et. al.Basic information
Original name
Retinal photoreceptor apoptosis is associated with impaired serum ionized calcium homeostasis in diabetic retinopathy: An in-vivo analysis
Authors
ANKITA, A. (356 India), Sandeep SAXENA (356 India), Dwividendra K. NIM (356 India), Jana STEFANICKOVA (703 Slovakia), Peter ZIAK (703 Slovakia), Patrik STEFANICKA (703 Slovakia) and Peter KRUŽLIAK (703 Slovakia, guarantor, belonging to the institution)
Edition
Journal of Diabetes and its Complications, New York, Elsevier Science Inc. 2019, 1056-8727
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30202 Endocrinology and metabolism
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 2.781
RIV identification code
RIV/00216224:14110/19:00110191
Organization unit
Faculty of Medicine
UT WoS
000459522300006
Keywords in English
Diabetic retinopathy; Ionized calcium; Spectral-domain optical coherence tomography; Retinal photoreceptor apoptosis; Autophagy; Ellipsoid zone
Tags
International impact, Reviewed
Změněno: 16/7/2019 15:50, Soňa Böhmová
Abstract
V originále
Purpose: The aim of this work was to study the association of serum ionized calcium with retinal photoreceptor apoptosis on spectral domain optical coherence tomography (SD-OCT) in diabetic retinopathy (DR). Methods: Sixty consecutive cases with Type 2 diabetes mellitus were categorized into three groups: no diabetic retinopathy; non-proliferative DR; proliferative DR. The eye with more severe form of the disease was considered. Twenty healthy controls were also included. Best corrected visual acuity (BCVA) was measured on logMAR scale. Retinal photoreceptor apoptosis was defined as disruption of retinal photoreceptor ellipsoid zone (EZ). Ellipsoid zone disruption was assessed using SD-OCT. Serum levels of total and ionized calcium were measured using standard protocol. Results: EZ disruption was found to be positively associated with serum total calcium and ionized calcium. Also, EZ disruption was found to be positively associated with logMAR BCVA. Conclusion: Increased serum ionized calcium induces retinal photoreceptor apoptosis resulting in increased EZ disruption in DR.