Markers of Atherosclerosis. Part 2, Genetic and Imaging Markers

J 2019

Markers of Atherosclerosis. Part 2, Genetic and Imaging Markers

TIBAUT, Miha, Martin CAPRNDA, Peter KUBATKA, Andreja SINKOVIC, Vanda VALENTOVA et. al.

Basic information

Original name

Markers of Atherosclerosis. Part 2, Genetic and Imaging Markers

Authors

TIBAUT, Miha (705 Slovenia), Martin CAPRNDA (703 Slovakia), Peter KUBATKA (703 Slovakia), Andreja SINKOVIC (705 Slovenia), Vanda VALENTOVA (703 Slovakia), Slavomira FILIPOVA (703 Slovakia), Katarina GAZDIKOVA (703 Slovakia), Ludovit GASPAR (703 Slovakia), Ioana MOZOS (642 Romania), Emmanuel E. EGOM (124 Canada), Luis RODRIGO (724 Spain), Peter KRUŽLIAK (703 Slovakia, guarantor, belonging to the institution) and Daniel PETROVIC (705 Slovenia)

Edition

HEART LUNG AND CIRCULATION, NEW YORK, ELSEVIER SCIENCE INC, 2019, 1443-9506

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.194

RIV identification code

RIV/00216224:14110/19:00108496

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.hlc.2018.09.006

UT WoS

000462780100008

Keywords in English

Biomarkers; Atherosclerosis; Genetic polymorphism; Imaging biomarkers; Carotid intima media thickness; Micro RNA

Abstract

V originále

This is Part 2 of a two-part review summarising current knowledge on biomarkers of atherosclerosis. Part 1 addressed serological biomarkers. Here, in part 2 we address genetic and imaging markers, and other developments in predicting risk. Further improvements in risk stratification are expected with the addition of genetic risk scores. In addition to single nucleotide polymorphisms (SNPs), recent advances in epigenetics offer DNA methylation profiles, histone chemical modifications, and micro-RNAs as other promising indicators of atherosclerosis. Imaging biomarkers are better studied and already have a higher degree of clinical applicability in cardiovascular (CV) event prediction and detection of preclinical atherosclerosis. With new methodologies, such as proteomics and metabolomics, discoveries of new clinically applicable biomarkers are expected.

Links

NV17-29701A, research and development project

Name: Ischémií modifikovaný albumin a cirkulující mikroRNA jako nové technologie k monitorování tkáňové ischémie po cévních rekonstrukcích na břišní aortě

Citovat

TIBAUT, Miha, Martin CAPRNDA, Peter KUBATKA, Andreja SINKOVIC, Vanda VALENTOVA, Slavomira FILIPOVA, Katarina GAZDIKOVA, Ludovit GASPAR, Ioana MOZOS, Emmanuel E. EGOM, Luis RODRIGO, Peter KRUŽLIAK and Daniel PETROVIC. Markers of Atherosclerosis. Part 2, Genetic and Imaging Markers. HEART LUNG AND CIRCULATION. NEW YORK: ELSEVIER SCIENCE INC, 2019, vol. 28, No 5, p. 678-689. ISSN 1443-9506. Available from: https://dx.doi.org/10.1016/j.hlc.2018.09.006.

@article{1545972,
   author = {Tibaut, Miha and Caprnda, Martin and Kubatka, Peter and Sinkovic, Andreja and Valentova, Vanda and Filipova, Slavomira and Gazdikova, Katarina and Gaspar, Ludovit and Mozos, Ioana and Egom, Emmanuel E. and Rodrigo, Luis and Kružliak, Peter and Petrovic, Daniel},
   article_location = {NEW YORK},
   article_number = {5},
   doi = {http://dx.doi.org/10.1016/j.hlc.2018.09.006},
   keywords = {Biomarkers; Atherosclerosis; Genetic polymorphism; Imaging biomarkers; Carotid intima media thickness; Micro RNA},
   language = {eng},
   issn = {1443-9506},
   journal = {HEART LUNG AND CIRCULATION},
   title = {Markers of Atherosclerosis. Part 2, Genetic and Imaging Markers},
   url = {http://dx.doi.org/10.1016/j.hlc.2018.09.006},
   volume = {28},
   year = {2019}
}

TY  - JOUR
ID  - 1545972
AU  - Tibaut, Miha - Caprnda, Martin - Kubatka, Peter - Sinkovic, Andreja - Valentova, Vanda - Filipova, Slavomira - Gazdikova, Katarina - Gaspar, Ludovit - Mozos, Ioana - Egom, Emmanuel E. - Rodrigo, Luis - Kružliak, Peter - Petrovic, Daniel
PY  - 2019
TI  - Markers of Atherosclerosis. Part 2, Genetic and Imaging Markers
JF  - HEART LUNG AND CIRCULATION
VL  - 28
IS  - 5
SP  - 678-689
EP  - 678-689
PB  - ELSEVIER SCIENCE INC
SN  - 14439506
KW  - Biomarkers
KW  - Atherosclerosis
KW  - Genetic polymorphism
KW  - Imaging biomarkers
KW  - Carotid intima media thickness
KW  - Micro RNA
UR  - http://dx.doi.org/10.1016/j.hlc.2018.09.006
L2  - http://dx.doi.org/10.1016/j.hlc.2018.09.006
N2  - This is Part 2 of a two-part review summarising current knowledge on biomarkers of atherosclerosis. Part 1 addressed serological biomarkers. Here, in part 2 we address genetic and imaging markers, and other developments in predicting risk. Further improvements in risk stratification are expected with the addition of genetic risk scores. In addition to single nucleotide polymorphisms (SNPs), recent advances in epigenetics offer DNA methylation profiles, histone chemical modifications, and micro-RNAs as other promising indicators of atherosclerosis. Imaging biomarkers are better studied and already have a higher degree of clinical applicability in cardiovascular (CV) event prediction and detection of preclinical atherosclerosis. With new methodologies, such as proteomics and metabolomics, discoveries of new clinically applicable biomarkers are expected.
ER  -

TIBAUT, Miha, Martin CAPRNDA, Peter KUBATKA, Andreja SINKOVIC, Vanda VALENTOVA, Slavomira FILIPOVA, Katarina GAZDIKOVA, Ludovit GASPAR, Ioana MOZOS, Emmanuel E. EGOM, Luis RODRIGO, Peter KRUŽLIAK and Daniel PETROVIC. Markers of Atherosclerosis. Part 2, Genetic and Imaging Markers. \textit{HEART LUNG AND CIRCULATION}. NEW YORK: ELSEVIER SCIENCE INC, 2019, vol.~28, No~5, p.~678-689. ISSN~1443-9506. Available from: https://dx.doi.org/10.1016/j.hlc.2018.09.006.

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