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@article{1545976,
author = {Kapinova, Andrea and Kubatka, Peter and Liskova, Alena and Baranenko, Denis and Kružliak, Peter and Matta, Milan and Busselberg, Dietrich and Malicherova, Bibiana and Zulli, Anthony and Kwon, Taeg Kyu and Jezkova, Eva and Blahutova, Dana and Zubor, Pavol and Danko, Jan},
article_location = {Germany},
article_number = {5},
doi = {http://dx.doi.org/10.1007/s00432-019-02892-5},
keywords = {Metastatic cancer; Signaling pathways; Phytochemicals; Chemoprevention; Therapy},
language = {eng},
issn = {0171-5216},
journal = {Journal of cancer research and clinical oncology},
title = {Controlling metastatic cancer: the role of phytochemicals in cell signaling},
url = {http://dx.doi.org/10.1007/s00432-019-02892-5},
volume = {145},
year = {2019}
}
TY - JOUR
ID - 1545976
AU - Kapinova, Andrea - Kubatka, Peter - Liskova, Alena - Baranenko, Denis - Kružliak, Peter - Matta, Milan - Busselberg, Dietrich - Malicherova, Bibiana - Zulli, Anthony - Kwon, Taeg Kyu - Jezkova, Eva - Blahutova, Dana - Zubor, Pavol - Danko, Jan
PY - 2019
TI - Controlling metastatic cancer: the role of phytochemicals in cell signaling
JF - Journal of cancer research and clinical oncology
VL - 145
IS - 5
SP - 1087-1109
EP - 1087-1109
PB - Springer-Verlag
SN - 01715216
KW - Metastatic cancer
KW - Signaling pathways
KW - Phytochemicals
KW - Chemoprevention
KW - Therapy
UR - http://dx.doi.org/10.1007/s00432-019-02892-5
L2 - http://dx.doi.org/10.1007/s00432-019-02892-5
N2 - PurposeCancer is a serious health issue and a leading cause of death worldwide. Most of the cancer patients (approximately 90%) do not die from the consequences of the primary tumor development, but due to a heavily treatable metastatic invasion. During the lengthy multistep process of carcinogenesis, there are a lot of opportunities available to reverse or slow down the tissue invasion or the process of tumor metastasis formation.ResultsCurrent research has brought many promising results from anti-metastatic experimental studies, and has shown that chemoprevention by natural or semisynthetic phytochemicals with plethora of biological activities could be one of the potentially effective options in the fight against this problem. However, there is a lack of clinical trials to confirm these findings. In this review, we focused on summarization and discussion of the general features of metastatic cancer, and recent preclinical and clinical studies dealing with anti-metastatic potential of various plant-derived compounds.ConclusionsBased on our findings, we can conclude and confirm our hypothesis that phytochemicals with pleiotropic anticancer effects can be very useful in retarding and/or reversing the metastasis process, and can also be used to prevent tissue invasion and metastases. But, further studies in this area are certainly necessary and desirable.
ER -
KAPINOVA, Andrea, Peter KUBATKA, Alena LISKOVA, Denis BARANENKO, Peter KRUŽLIAK, Milan MATTA, Dietrich BUSSELBERG, Bibiana MALICHEROVA, Anthony ZULLI, Taeg Kyu KWON, Eva JEZKOVA, Dana BLAHUTOVA, Pavol ZUBOR and Jan DANKO. Controlling metastatic cancer: the role of phytochemicals in cell signaling. \textit{Journal of cancer research and clinical oncology}. Germany: Springer-Verlag, 2019, vol.~145, No~5, p.~1087-1109. ISSN~0171-5216. Available from: https://dx.doi.org/10.1007/s00432-019-02892-5.
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